Recombinant Human CXCR4 Protein, Fc-tagged

Cat.No. : CXCR4-186H
Product Overview : Recombinant human CXCR4 protein with Fc tag was expressed in HEK293.
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Description : This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized
Molecular Mass : 32.8 kDa
Protein Length : 352
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens (human) ]
Official Symbol : CXCR4
Synonyms : CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL;
Gene ID : 7852
mRNA Refseq : NM_001008540
Protein Refseq : NP_001008540
MIM : 162643
UniProt ID : P61073

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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    The responsive customer support team provided quick resolutions to any queries or issues we encountered.


      The product's cost-effectiveness and clear instructions were instrumental in our experimental design.


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        Q&As (7)

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        How does CXCR4 participate in chemotaxis and migration of immune cells, particularly in the context of the immune response? 01/26/2022

        CXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.

        Are there specific chemokines or ligands that CXCR4 binds to, influencing its role in immune cell activation and recruitment? 01/09/2020

        Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.

        In which cellular compartments is CXCR4 predominantly localized, especially within immune cells? 06/14/2019

        CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.

        What diseases or conditions are associated with dysregulation or abnormal expression of CXCR4, especially in the immune system? 03/27/2019

        Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.

        Are there therapeutic implications or potential targets related to CXCR4 in diseases involving immune dysregulation and inflammation? 06/28/2018

        There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.

        How does CXCR4 contribute to the regulation of inflammatory responses and immune cell trafficking in various tissues? 08/30/2017

        CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.

        What is the primary function of C-X-C chemokine receptor type 4 (CXCR4) in cellular processes and immune responses? 06/27/2016

        C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.

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