cxcr4

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cxcr4

Official Full Name chemokine (C-X-C motif) receptor 4
Background This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • His-GST
    • human
    • IgG1
    • Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCR4-1175H Recombinant Human CXCR4 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Human CXCR4-1176H Recombinant Human CXCR4 protein isoform 2, His-tagged E.coli His
    Human CXCR4-19H Recombinant Human CXCR4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CXCR4-2181H Recombinant Human CXCR4 Protein, GST-tagged Wheat Germ GST
    Human CXCR4-503H Recombinant Human CXCR4, His-tagged Yeast His
    Human CXCR4-504H Recombinant Human CXCR4 Wheat Germ N/A
    Human CXCR4-510H Recombinant Human CXCR4 protein, His-tagged E.coli His
    Human CXCR4-5138H Recombinant Human CXCR4, GST-tagged E.coli GST
    Human CXCR4-7161HCL Recombinant Human CXCR4 293 Cell Lysate HEK293 N/A
    Mouse CXCR4-40M Recombinant Mouse CXCR4 Protein, His-GST-tagged E. coli His-GST
    Mouse CXCR4-4110M Recombinant Mouse CXCR4 Protein Mammalian Cell His
    Rhesus Macaque CXCR4-1115R Recombinant Rhesus monkey CXCR4 Protein, His-tagged Mammalian Cell His
    Chicken CXCR4-6185C Recombinant Chicken CXCR4 Mammalian Cell His
    Kit-1197 cAMP CXCR4 CHO-K1 GPCR Assay Kit N/A
    Kit-1198 cAMP CHO-K1 CXCR4 Bioassay Kit N/A
    Kit-1199 CXCR4 Total GPCR Internalization Assay Kit N/A

    cxcr4 involved in several pathways and played different roles in them. We selected most pathways cxcr4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcr4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction EDAR; IFNA14; ACVR1L; VEGFA; CCL27; KITA; IL28RA; INHBC; TNFSF10; CCL1
    Chemokine signaling pathway CCR3; GNG10; LYN; CXCL5; WAS; CXCL3; GNB3; CCL14; PIK3R2; Ccl21a
    Endocytosis CHMP3; KITA; ITCH; ADRB3B; CXCR4A; HSPA1A; ARF1L; WASLB; STAMBP; SH3GLB1
    Axon guidance UNC5D; EPHB3; SCN2B; ITGB3A; SEMA3G; GPC1B; TRPC5; CSNK2B; SPTB; KCNQ2
    Leukocyte transendothelial migration CLDN15; ARHGAP35; CXCL12; PIK3R5; ACTN3; Itgam&Itgb2; CDC42; ACTN4; EZR; CLDN1
    Intestinal i HLA-DRB5; ICOS; CXCL12B; CXCL12A; AICDA; HLA-DRB3; HLA-DOA; CD40; CCL27B; TNFRSF17
    ne network for IgA production HLA-DRB4; HLA-DRB1; AICDA; HLA-DPB1; ICOS; IL15; HLA-DQA1; HLA-DMB; MHC2DAB; CXCR4B
    Pathways in cancer BIRC5; GNA11; MAPK8; SMAD3; FZD7; FZD2; TRAF4; KRAS; FGF10; RAD51

    cxcr4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcr4 itself. We selected most functions cxcr4 had, and list some proteins which have the same functions with cxcr4. You can find most of the proteins on our site.

    Function Related Protein
    C-X-C chemokine receptor activity CCR9A; CXCR4A; CXCR7; CXCR5; CXCR3; CXCR6; CCBP2; CXCR3.1; CXCR2; CXCR4B
    G-protein coupled receptor activity F2RL2; TAS1R2.2; HCAR1-1; APLNR; GPR34B; GPR115; OR6K3; EXORH; OLFR1013; MRGPRD
    actin binding SMYHC2; PARVAB; TNNI3; PFN2L; MYO1G; MYHC4; ITGB1; VASPA; CAP2; ADD3
    coreceptor activity CXCR6; CD8B; RGMB; CXCR7B; ACVR2A; ZP2; CD4; LRP5; TMIGD2; RGMA
    cytokine binding Fzd4; CSF1RA; NRP2; NOG; IL17F; ELANE; CRLF1; KITA; CD74; CSF1R
    myosin light chain binding MYOC; CXCR4; SPATA6; MYO19
    protein binding HAND2; MGST3; COG1; TBXA2R; AAK1; MTMR14; MYLK; DRD1A; NAGK; DTX3L
    ubiquitin binding USP16; FAN1; SIRT2; SPRTN; KCNS1; UBXN2B; BCL10; SHRPRBCK1R; OTUB2; MARK4
    ubiquitin protein ligase binding PRKAR2B; UBXN6; KCNH2; IKBKE; FAF2; CASP8; FLJ11011L; ATP6V0C; NLK; CUL4A
    virus receptor activity SERPINB3; EFNB2; DAG1; SCARB2; HLA-DRB1; GYPA; IDE; TYRO3; LDLR; SLC10A1

    cxcr4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcr4 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcr4.

    DBN1; CD74; MYH9; Dbn1; CD164; CCR5

    Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
    Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).

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