cxcr4
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  • Official Full Name
  • chemokine (C-X-C motif) receptor 4
  • Background
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
Cat.#:CXCR4-1175HTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4 Protein, His-SUMO/MYC-tagged
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Cat.#:CXCR4-2181HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR4 Protein, GST-tagged
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Cat.#:CXCR4-19HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCR4, Fc-tagged
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Cat.#:CXCR4-503HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CXCR4, His-tagged
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Cat.#:CXCR4-504HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR4
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Cat.#:CXCR4-5138HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4, GST-tagged
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Cat.#:CXCR4-4110MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCR4 Protein
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Cat.#:CXCR4-1115RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCR4 Protein, His-tagged
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Cat.#:CXCR4-6185CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCR4
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Cat.#:CXCR4-7161HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCR4 293 Cell Lysate
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Cat.#:Kit-1197Tag:
Source (Host):Species:
Product namecAMP CXCR4 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1198Tag:
Source (Host):Species:
Product namecAMP CHO-K1 CXCR4 Bioassay Kit
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Cat.#:Kit-1199Tag:
Source (Host):Species:
Product nameCXCR4 Total GPCR Internalization Assay Kit
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Involved Pathway

CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TGFB2; TSLP; GM13305; IL2RB; LIF; IL18; IFNK; CCL4; CXCL12A; IL6R
Chemokine signaling pathway
CCL21B; Adcy4; WAS; CXCL9; CXCL5; CCR8; SHC1; CCR10; CXCR6; AMCF-II
Endocytosis
MVB12BA; ZFYVE9; SMAP1; LDLRAP1A; PIP5K1B; D6WSU116E; ARF1L; ERBB4; RAB31; HRASA
Axon guidance
SPRED2; PLXNA1; SCN9A; GNAI2; ABLIM2; EPHA4; ARHGEF12; SCN2B; LRRC4C; ROCK1
Leukocyte transendothelial migration
CLDN11; PIK3R1; MYL5; CDC42; EZR; ITGB2L; ITGAM; CLDN14; NOX1; PIK3CA
Intestinal i
Il2; HLA-DQA2; MHC2DAB; CXCL12; CD86; BLA; IL15; PIGR; CCL28; MADCAM1
ne network for IgA production
CD40; ICOSLG; CD28; IL15; BLB1; MHC2DEB; HLA-DRB5; AICDA; BLA; Icosl
Pathways in cancer
BCL2L1; APC; WNT4; ARHGEF12; ITGA6; STK36; LAMC2; FLT3LG; PDGFA; PTGER1

Protein Function

CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.
Function
Related Protein
Function C-X-C chemokine receptor activity
Related Protein CXCR3; CXCR4A; CXCR3.1; CXCR5; CXCR7; CCR9A; CXCR2; CXCR4; CXCR6; CCBP2
Function G-protein coupled receptor activity
Related Protein OR51D1; TAAR6; OR6K3; ADRB3A; TAAR14A; OR6B2; OPN4XA; TAAR10A; FPR-RS3; GPR183A
Function actin binding
Related Protein SNTB2; DIAPH3; ARPC5L; DMTN; PALLD; VASPA; ESPN; EPB41L3A; GCET2; MYH9
Function coreceptor activity
Related Protein RAMP3; RGMA; RGMD; ACVR2A; CXCR7; CD80; CD86; NRP1; CD8A; CCR8
Function cytokine binding
Related Protein IL31RA; CNTFR; CSF1RA; ELANE; KITB; TNFRSF11A; NRP1; CHRD; Fzd4; CSF1R
Function myosin light chain binding
Related Protein CXCR4; SPATA6; MYOC; MYO19
Function protein binding
Related Protein DTX3L; SF3B4; RBL2; BCL11B; Acr; TEKT4; SREK1; RNF168; E2F8; CAMTA2
Function ubiquitin binding
Related Protein VPS28; D17WSU92E; SIRT2; UBXN1; OTUB1A; UBXN11; AUP1; CXCR4; UCHL1; IDE
Function ubiquitin protein ligase binding
Related Protein UBE2U; GPR37; CASP10; HIF1A; PARK2; PPARGC1A; PRKACB; TCP1; RNF34; IKBKG
Function virus receptor activity
Related Protein MOG; ITGB1; TFRC; AXL; LDLR; CR1; GYPA; CLEC4M; CCR5; SCARB1

Interacting Protein

CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.
DBN1; CD74; MYH9; Dbn1; CD164; CCR5

CXCR4 Related Articles

Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).

CXCR4 Related Gene Family

Chemokines Cytokines