cxcr4 Protein, chemokine (C-X-C motif) receptor 4

cxcr4

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cxcr4

Official Full Name chemokine (C-X-C motif) receptor 4
Background This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • human
    • IgG1
    • Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCR4-1176H Recombinant Human CXCR4 protein isoform 2, His-tagged E.coli His
    Human CXCR4-510H Recombinant Human CXCR4 protein, His-tagged E.coli His
    Human CXCR4-1175H Recombinant Human CXCR4 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Human CXCR4-19H Recombinant Human CXCR4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CXCR4-2181H Recombinant Human CXCR4 Protein, GST-tagged Wheat Germ GST
    Human CXCR4-503H Recombinant Human CXCR4, His-tagged Yeast His
    Human CXCR4-504H Recombinant Human CXCR4 Wheat Germ N/A
    Human CXCR4-5138H Recombinant Human CXCR4, GST-tagged E.coli GST
    Human CXCR4-7161HCL Recombinant Human CXCR4 293 Cell Lysate HEK293 N/A
    Mouse CXCR4-4110M Recombinant Mouse CXCR4 Protein Mammalian Cell His
    Rhesus Macaque CXCR4-1115R Recombinant Rhesus monkey CXCR4 Protein, His-tagged Mammalian Cell His
    Chicken CXCR4-6185C Recombinant Chicken CXCR4 Mammalian Cell His
    Kit-1197 cAMP CXCR4 CHO-K1 GPCR Assay Kit N/A
    Kit-1198 cAMP CHO-K1 CXCR4 Bioassay Kit N/A
    Kit-1199 CXCR4 Total GPCR Internalization Assay Kit N/A

    cxcr4 involved in several pathways and played different roles in them. We selected most pathways cxcr4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcr4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction BMPR1B; EDA; TNFRSF9A; CXCL3; IL17RA; FLT4; IL20RA; TNFSF14; FASLG; FIGF
    Chemokine signaling pathway BRAF; PIK3R1; GSK3B; XCR1; PIK3R5; CXCL2; Ccl21c; JAK3; GNGT2; CCL15
    Endocytosis VTA1; PML; IGF2R; ARPC5B; ARAP1; WASLA; AGAP1; CAV3; CYTH2; CYTH1B
    Axon guidance PITPNA; PAK7; LAMTOR2; RASGRP4; SHB; CDC42; EFNA3; COL4A4; EFNA1; EFNB2
    Leukocyte transendothelial migration CDC42; PIK3CA; VAV2; ACTN1; NOX1; PXN; MYLPF; PIK3R3; CLDN18; ITGAM
    Intestinal i BMA2; HLA-DRB5; TNFRSF17; ITGB7; ICOS; HLA-DQB1; PIGR; CCR9A; ITGA4; IL15RA
    ne network for IgA production BLB2; TNFRSF17; HLA-DPB1; HLA-DOB; TGFB1A; HLA-DRB3; CD40; MHC2A; TNFSF13; MHC2DEB
    Pathways in cancer LPAR5; FGF18; DAPK3; FGF1; WNT6; EGLN3; TRAF6; FGF11; Casp3; FIGF

    cxcr4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcr4 itself. We selected most functions cxcr4 had, and list some proteins which have the same functions with cxcr4. You can find most of the proteins on our site.

    Function Related Protein
    C-X-C chemokine receptor activity CXCR2; CXCR4B; CXCR4A; CXCR3; CXCR5; CXCR4; CXCR3.1; CXCR6; CCBP2; CCR9A
    G-protein coupled receptor activity OR2F1; TAAR7F; GNRHR2; APLNRB; RHOL; LPAR5B; TAS2R116; TAAR14L; ADRA1BB; LPAR1
    actin binding ARPC1A; MTSS1L; DNASE1; SHANK3; MYO15; MSRB1; TNNT2A; CCDC88A; CALD1B; XIRP2
    coreceptor activity LY96; LRP5; CD4; RAMP1; CXCR6; CD28; RAMP3; RGMA; TGFBR3; HFE2
    cytokine binding IL17F; CNTFR; CHRD; Fzd4; TNFRSF11A; PARK7; KITA; ELANE; NOG; GBP1
    myosin light chain binding MYO19; SPATA6; MYOC; CXCR4
    protein binding ASCL3; SSX3; ITGB7; RRAGC; GAS2L3; KCNE1; PPIF; ITM2A; PRKD2; GPR85
    ubiquitin binding UBAP1; NUP62; FAM125A; SMAD3; CXCR4; FAN1; OTUB1B; IDE; AUP1; UBXN11
    ubiquitin protein ligase binding Fzd4; PPARGC1A; SPOP; TRAF6; UBE2Z; UBE2V2; HSPA8; FZD8; STX8; AKTIP
    virus receptor activity CLEC4G; TNFRSF4; TNFRSF14; SLC20A2; ITGB1; ITGB5; SLAMF1; LDLR; CCR5; TFRC

    cxcr4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcr4 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcr4.

    DBN1; CD74; MYH9; Dbn1; CD164; CCR5

    Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
    Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).

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