cxcr4
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  • Official Full Name
  • chemokine (C-X-C motif) receptor 4
  • Background
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
Cat.#:CXCR4-1175HTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4 Protein, His-SUMO/MYC-tagged
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Cat.#:CXCR4-2181HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCR4 Protein, GST-tagged
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Cat.#:CXCR4-19HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCR4, Fc-tagged
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Cat.#:CXCR4-503HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CXCR4, His-tagged
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Cat.#:CXCR4-504HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CXCR4
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Cat.#:CXCR4-5138HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCR4, GST-tagged
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Cat.#:CXCR4-4110MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CXCR4 Protein
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Cat.#:CXCR4-1115RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCR4 Protein, His-tagged
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Cat.#:CXCR4-6185CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCR4
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Cat.#:CXCR4-7161HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCR4 293 Cell Lysate
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Cat.#:Kit-1197Tag:
Source (Host):Species:
Product namecAMP CXCR4 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-1198Tag:
Source (Host):Species:
Product namecAMP CHO-K1 CXCR4 Bioassay Kit
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Cat.#:Kit-1199Tag:
Source (Host):Species:
Product nameCXCR4 Total GPCR Internalization Assay Kit
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Cat.#:CSC-RG0043Tag:
Source (Host):Species:Human
Product nameHuman CXCR4-SNAP Stable Cell Line-HEK293
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Cat.#:CSC-RG0222Tag:
Source (Host):Species:Human
Product nameHuman CXCR4-FLAG Stable Cell Line-HEK293T
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Cat.#:CSC-RG0505Tag:
Source (Host):Species:Human
Product nameHuman CXCR4/Gi Stable Cell Line-CHO
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Cat.#:CSC-RG0642Tag:
Source (Host):Species:Human
Product nameHuman CXCR4/Galpha15 Stable Cell Line-Chem-1
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Cat.#:CSC-RG0827Tag:
Source (Host):Species:Human
Product nameHuman CXCR4 Stable Cell Line-HEK293-CNG
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Involved Pathway

CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL23; Ccl27a; Flt3l; IL17RA; CCL7; EPOR; IL22RA2; CSF1RA; IL21R.1; CCL20
Chemokine signaling pathway
ARRB2; GNG2; STAT1; GNG11; KRAS; GRK5; CCR6; CCL4L1; IL-8; VAV3
Endocytosis
RHOAD; WASB; SH3GL1B; HSPA2; SNX3; CLTCA; CAPZA3; VPS37D; CHMP5; RAB11FIP4
Axon guidance
SDCBP; PPP3R2; SLIT3; NEFLB; AP2B1; SEMA6A; EFNB2A; COL6A3; COL4A3; GPC1A
Leukocyte transendothelial migration
ARHGAP5; PLCG1; MYL2; CLDN15; PIK3R2; CLDN22; CLDN14; MYL5; CLDN11; CLDN3
Intestinal i
CD86; PIGR; CCR10; CXCR4A; LTBR; CD40; CCL28; HLA-DMB; HLA-DPB1; MHC2A
ne network for IgA production
MHC2DAB; HLA-DOB; MADCAM1; CCR9A; TGFB1; MHC2A; CD40; BMA1; ICOS; HLA-DPB1
Pathways in cancer
FGF11; GNAI1; CXCL12; RARA; IKBKB; STAT3; BIRC8; PAX8; BIRC5; RUNX1

Protein Function

CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.
Function
Related Protein
Function C-X-C chemokine receptor activity
Related Protein CXCR6; CCBP2; CXCR7; CXCR2; CXCR5; CXCR4; CXCR4A; CCR9A; CXCR4B; CXCR3.1
Function G-protein coupled receptor activity
Related Protein TAS2R134; TAAR8B; CXCR1; HTR1AA; TAAR14E; GPR125; OLFR958; GPR184; V2RH14; PARAPINOPSINB
Function actin binding
Related Protein MACF1; MICAL2B; MYH9A; WASF1; CAPZB; MYH6; PDLIM5; TPM4; CFL2; DST
Function coreceptor activity
Related Protein ACKR3B; NRP1; CXCR6; ACVR2A; RGMA; RAMP2; CXCR4; TMIGD2; IGSF1; CD8A
Function cytokine binding
Related Protein NRP2; CXCR4; PARK7; CSF1RA; KIT; KITA; IFNGR1; IL17F; KITB; CHRD
Function myosin light chain binding
Related Protein CXCR4; MYOC; SPATA6; MYO19
Function protein binding
Related Protein CCDC112; TMUB2; SOST; DDX23; ATP7A; HIST1H3G; URM1; SMCP; LMF2; DERL2
Function ubiquitin binding
Related Protein MARK4; SPRTN; UCHL3; FAF1; NBR1; OTUB2; TOM1L1; D17WSU92E; TRIM32; UBXN11
Function ubiquitin protein ligase binding
Related Protein UBE2G1B; FZD8; PRDX6; PRR5L; CUL1; CALR; TCEB2; LC3; ERLIN2; AICDA
Function virus receptor activity
Related Protein CD4; SLC20A2; CD209; PVR; SERPINB3; HTR2A; SCARB1; SLC1A5; GPR172B; NPC1

Interacting Protein

CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.
DBN1; CD74; MYH9; Dbn1; CD164; CCR5

CXCR4 Related Articles

Thapa, D; Ghosh, R; et al. Chronic inflammatory mediators enhance prostate cancer development and progression. BIOCHEMICAL PHARMACOLOGY 94:53-62(2015).
Wang, RSE; Liu, T; et al. An Immunosuppressive Antibody-Drug Conjugate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137:3229-3232(2015).

CXCR4 Related Gene Family

Chemokines Cytokines