CXCR4

  • Official Full Name

    chemokine (C-X-C motif) receptor 4

  • Overview

    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
  • Chicken
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Felis catus (Cat) (Felis silvestris catus)
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pan troglodytes (Chimpanzee)
  • Papio anubis (Olive baboon)
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Saimiri sciureus (Common squirrel monkey)
  • Sus scrofa (Pig)
  • Tupaia chinensis (Chinese tree shrew)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • C
  • hFc
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • His|SUMO|Myc
  • SUMO
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCR4-3954H Active Recombinant Human CXCR4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CXCR4-504H Recombinant Human CXCR4 Wheat Germ N/A
Human CXCR4-19H Recombinant Human CXCR4 protein, Fc-tagged HEK293 human/IgG1/Fc Met1-Ser46
Human CXCR4-1175H Recombinant Human CXCR4 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human CXCR4-5138H Recombinant Human CXCR4, GST-tagged E.coli GST
Human CXCR4-503H Recombinant Human CXCR4, His-tagged Yeast His
Human CXCR4-2181H Recombinant Human CXCR4 Protein, GST-tagged Wheat Germ GST
Human CXCR4-7161HCL Recombinant Human CXCR4 293 Cell Lysate HEK293 N/A
Human CXCR4-1437H Recombinant Human CXCR4 Protein (Ser217-Ser352), N-His tagged E.coli N-His Ser217-Ser352
Human CXCR4-1176H Recombinant Human CXCR4 Full Length Transmembrane protein isoform 2, His-tagged In vitro E. coli expression system His 1-356aa
Human CXCR4-2365H Recombinant Human CXCR4 Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-356aa
Human CXCR4-510H Recombinant Human CXCR4 protein, His-tagged E.coli His 91
Human CXCR4-1038H Active Recombinant Human CXCR4 Full Length Transmembrane protein, His-tagged HEK293 His 1-352aa
Human CXCR4-2780H Recombinant Human CXCR4 protein, GST-tagged E.coli GST 303-352aa
Human CXCR4-1083HFL Recombinant Human CXCR4 protein, His&Flag-tagged HEK293 His&Flag 1-356 aa
Human CXCR4-2316HF Recombinant Full Length Human CXCR4 Protein, GST-tagged In Vitro Cell Free System GST 352 amino acids
Human CXCR4-6894HF Recombinant Full Length Human CXCR4 Protein In Vitro Cell Free System 352 amino acids
Human CXCR4-3046H Active Recombinant Human CXCR4 protein HEK293 N/A Met 1-Ser 352
Human CXCR4-762H Active Recombinant Human CXCR4 Full Length Transmembrane protein(VLPs) HEK293 N/A Met1-Ser352
Human CXCR4-593M CXCR4 protein-coupled magnetic MicroBeads
Human CXCR4-186H Recombinant Human CXCR4 Protein, Fc-tagged HEK293 Fc 352
Human CXCR4-011H Recombinant Human CXCR4 Protein, C-hFc tagged HEK293 C-hFc
Mouse CXCR4-4110M Recombinant Mouse CXCR4 Protein Mammalian Cell His
Mouse CXCR4-2101M-B Recombinant Mouse CXCR4 Protein Pre-coupled Magnetic Beads HEK293
Mouse CXCR4-40M Recombinant Mouse CXCR4 Protein, His-GST-tagged E.coli His-GST Asp269~Ser359
Mouse CXCR4-2101M Recombinant Mouse CXCR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL31455BF Recombinant Full Length Bovine C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Callithrix jacchus (White-tufted-ear marmoset) RFL6381CF Recombinant Full Length Callithrix Jacchus C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Canis lupus familiaris (Dog) (Canis familiaris) RFL30672CF Recombinant Full Length Dog C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) RFL26747CF Recombinant Full Length Cercocebus Atys C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL28714CF Recombinant Full Length Chlorocebus Aethiops C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Felis catus (Cat) (Felis silvestris catus) RFL11086FF Recombinant Full Length Cat C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Homo sapiens (Human) RFL19303HF Recombinant Full Length Human C-X-C Chemokine Receptor Type 4(Cxcr4)-Vlps (Active) Protein, His-Tagged E.coli expression system His Full Length (1-352aa)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL26983MF Recombinant Full Length Macaca Fascicularis C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Macaca mulatta (Rhesus macaque) RFL21711MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Mus musculus (Mouse) RFL3130MF Recombinant Full Length Mouse C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Ovis aries (Sheep) RFL23816OF Recombinant Full Length Sheep C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-192)
Pan troglodytes (Chimpanzee) RFL19138PF Recombinant Full Length Pan Troglodytes C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Papio anubis (Olive baboon) RFL1336PF Recombinant Full Length Papio Anubis C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Rattus norvegicus (Rat) RFL6873RF Recombinant Full Length Rat C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-349)
Rhesus Macaque CXCR4-1115R Recombinant Rhesus monkey CXCR4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCR4-940R-B Recombinant Rhesus Macaque CXCR4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CXCR4-940R Recombinant Rhesus Macaque CXCR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Saimiri sciureus (Common squirrel monkey) RFL10582SF Recombinant Full Length Saimiri Sciureus C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Sus scrofa (Pig) RFL31178SF Recombinant Full Length Pig C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Tupaia chinensis (Chinese tree shrew) RFL29754TF Recombinant Full Length Tupaia Chinensis C-X-C Chemokine Receptor Type 4(Cxcr4) Protein, His-Tagged E.coli expression system His Full Length (1-352)
Chicken CXCR4-6185C Recombinant Chicken CXCR4 Mammalian Cell His
Kit-1199 CXCR4 Total GPCR Internalization Assay Kit N/A
Kit-1198 cAMP CHO-K1 CXCR4 Bioassay Kit N/A
Kit-1197 cAMP CXCR4 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • CXCR4 Related Signal Pathway

CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionBMPR1B;CCR1L1;CCR1;PRP2;TNFRSF11B;ACVR1;TGFBR1B;INHBA;IL22
Chemokine signaling pathwaySOS1;CCL20;GNG12;CXCL12;GRK7;STAT2;GNAI1;ADRBK2;GNG2
EndocytosisVPS29;CHMP7;DNM2;DNM3;PIP5K1BA;CLINT1A;RABEP1;WIPF1;VPS26BL
Axon guidanceEFNB3;DPYSL5B;EPHB3A;SRGAP2;DNM2;NRP2;DUSP7;COL9A3;CDC42
Leukocyte transendothelial migrationPIK3R2;CLDN3;ITGAM;ACTB;CLDN5;CDH5;PRKCA;THY1;CLDN16
Intestinal iHLA-DRB4;CD80;H2-AB1;TNFSF13;MHC2DEB;MHC2DCB;CXCL12A;MADCAM1;CXCR4B
ne network for IgA productionIL15RA;HLA-DRB5;AICDA;HLA-DMA;H2-AA;CD86;H2-AB1;MHC2A;HLA-DRB3
Pathways in cancerHGF;CCND1;PRKACA;FZD5;TGFBR1;BMP2;BDKRB1;RALBP1;Fgf15

CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.

Function Related Protein
C-X-C chemokine receptor activityCXCR6;CXCR4;CXCR3.1;CXCR4B;CXCR4A;CCR9A;CXCR5;CXCR7;CXCR2
G-protein coupled receptor activityGPR97;NTSR1;OLFR486;MLNR;GPR1;GPR148;MRGPRX3;CHRM2A;MRGPRA7
actin bindingINPPL1B;TBC1D21;EVLB;CORO2B;INF2;MYO1C;MYO7B;SMYHC3;FMN2
coreceptor activityCXCR7B;TGFBR3;NRP1;RGMD;LY96;RAMP1;ACVR2A;TMIGD2;CXCR6
cytokine bindingCRLF1;CSF1RA;ELANE;PARK7;IFNGR1;CXCR4;NRP2;IL31RA;NOG
myosin light chain bindingSPATA6;MYO19;MYOC;CXCR4
protein bindingCXXC11;C15orf23;NTN4;KRT5;ISY1;UBE2W;KRTAP13-3;HPX;CRCT1
ubiquitin bindingVPS36;UBXN2A;NSFL1C;UBAP1;C36E6.2;MARK4;AUP1;UBR5;TRP53INP2
ubiquitin protein ligase bindingIKBKE;ERLIN2;UBE2KB;CHEK2;TCEB2;UBOX5;UBE2W;GABARAPL2;TRAF6
virus receptor activityLDLR;SCARB2;CXADR;ACE2;DAG1;LAMP1;ITGA2;SLC20A2;ITGB6

CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.

DBN1; CD74; MYH9; Dbn1; CD164; CCR5

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CXCR4 participate in chemotaxis and migration of immune cells, particularly in the context of the immune response? 01/26/2022

CXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.

Are there specific chemokines or ligands that CXCR4 binds to, influencing its role in immune cell activation and recruitment? 01/09/2020

Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.

In which cellular compartments is CXCR4 predominantly localized, especially within immune cells? 06/14/2019

CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.

What diseases or conditions are associated with dysregulation or abnormal expression of CXCR4, especially in the immune system? 03/27/2019

Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.

Are there therapeutic implications or potential targets related to CXCR4 in diseases involving immune dysregulation and inflammation? 06/28/2018

There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.

How does CXCR4 contribute to the regulation of inflammatory responses and immune cell trafficking in various tissues? 08/30/2017

CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.

What is the primary function of C-X-C chemokine receptor type 4 (CXCR4) in cellular processes and immune responses? 06/27/2016

C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.

Customer Reviews (3)

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Reviews
04/07/2022

    The responsive customer support team provided quick resolutions to any queries or issues we encountered.

    10/28/2021

      The product's cost-effectiveness and clear instructions were instrumental in our experimental design.

      10/29/2018

        We found the product's straightforward protocols highly conducive to seamless integration into our lab work.

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