CXCR4
-
Official Full Name
chemokine (C-X-C motif) receptor 4
-
Overview
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Callithrix jacchus (White-tufted-ear marmoset)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
- Chicken
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Felis catus (Cat) (Felis silvestris catus)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Pan troglodytes (Chimpanzee)
- Papio anubis (Olive baboon)
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Saimiri sciureus (Common squirrel monkey)
- Sus scrofa (Pig)
- Tupaia chinensis (Chinese tree shrew)
- E. coli
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- hFc
- Fc
- GST
- His
- His (Fc)
- Avi
- Flag
- His|SUMO|Myc
- SUMO
- human|IgG1|Fc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CXCR4 Related Articles
- CXCR4 Related Gene Family
- CXCR4 Related Research Area
- CXCR4 Related Signal Pathway
CXCR4 involved in several pathways and played different roles in them. We selected most pathways CXCR4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cytokine-cytokine receptor interaction | CCR6A;TNFSF13B;GM2002;CXCR4A;CCL17;IL17RB;EDAR;IL-15RA;IL11RA2 |
Chemokine signaling pathway | ARRB2;GSK3A;GNG12;ADRBK1;CXCL6;FGR;CCL28;JAK3;HRAS |
Endocytosis | ARFGEF2;SPG20;SNX5;FOLR3;VPS26A;PLD1;RHOA;WASLA;WASL |
Axon guidance | RGMA;SLIT2;ROCK2;NFATC3;FRS2B;CDK5;PLXNB2;CSF2;CFL2 |
Leukocyte transendothelial migration | TXK;CLDN11;MSN;OCLN;VAV2;CLDN4;CLDN16;RHOA;PIK3R2 |
Intestinal i | IL6;HLA-DRA;Icosl;BLB2;BLB1;CCL25;TNFSF13;MHC2DEB;IL-15RA |
ne network for IgA production | IL4;CXCL12;HLA-DRA;ITGA4;CD40;IL5;ICOSLG;HLA-DMB;MHC2DAB |
Pathways in cancer | GNG8;Ar;FZD1;ARHGEF12;HDAC2;F2R;TP53;STAT5B;Casp3 |
CXCR4 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR4 itself. We selected most functions CXCR4 had, and list some proteins which have the same functions with CXCR4. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
C-X-C chemokine receptor activity | CXCR4A;CXCR4B;CXCR5;CCR9A;CXCR6;CXCR2;CXCR7;CXCR3;CXCR3.1 |
G-protein coupled receptor activity | GPR149;OPN1MW;HTR2CL1;LPAR2A;OR10H1;Fzd4;TMTOPS3A;OR4F29;VMN1R44 |
actin binding | EPS8;CORO2B;MYO6;TWF1A;WASF2;CNN1;PAWR;SVILA;PARK2 |
coreceptor activity | RGMB;IGSF1;CD28;TGFBR3;ZP2;CD4;RAMP1;CXCR6;CD80 |
cytokine binding | CHRD;NRP1;CSF1R;GBP1;IL31RA;CD74;CXCR4;IFNGR1;Fzd4 |
myosin light chain binding | SPATA6;MYOC;CXCR4;MYO19 |
protein binding | FAM113A;EVL;PPFIA2;SPERT;GPC3;RAB34;TAB2;PIWIL1;PPP1R2P9 |
ubiquitin binding | USP25;C36E6.2;TOP2A;C6orf106;VPS28;USP13;UBXN1;UCHL3;TSG101 |
ubiquitin protein ligase binding | CUL9;RNF31;BAG6;ERBB2;TOLLIP;SMAD6;BAG4;PML;TP53 |
virus receptor activity | CLEC5A;EFNB2;ICAM1;SCARB1;ITGB1;TYRO3;HSPA1B;CLDN1;F11R |
CXCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR4.
DBN1; CD74; MYH9; Dbn1; CD164; CCR5
- Q&As
- Reviews
Q&As (7)
Ask a questionCXCR4 participates in chemotaxis and migration of immune cells, facilitating their movement toward specific tissues during the immune response.
Specific chemokines or ligands, such as CXCL12, bind to CXCR4, influencing its role in immune cell activation and recruitment.
CXCR4 is predominantly localized on the cell surface of immune cells, particularly within the membrane of T cells and monocytes.
Dysregulation or abnormal expression of CXCR4 is associated with diseases such as cancer, HIV/AIDS, and autoimmune disorders, particularly affecting immune cell function.
There are potential therapeutic implications related to CXCR4 in diseases involving immune dysregulation and inflammation, making it a target for drug development.
CXCR4 contributes to the regulation of inflammatory responses and immune cell trafficking in various tissues, influencing the outcome of immune reactions.
C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in cellular processes, primarily contributing to immune responses and cell migration.
Customer Reviews (3)
Write a reviewThe responsive customer support team provided quick resolutions to any queries or issues we encountered.
The product's cost-effectiveness and clear instructions were instrumental in our experimental design.
We found the product's straightforward protocols highly conducive to seamless integration into our lab work.
Ask a Question for All CXCR4 Products
Required fields are marked with *
My Review for All CXCR4 Products
Required fields are marked with *