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Recombinant Human CYP3A4 Protein, GST-tagged

Cat.No. : CYP3A4-2273H
Product Overview : Human CYP3A4 full-length ORF ( AAI01632.1, 1 a.a. - 503 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 83.7 kDa
AA Sequence : MALIPDLAMETWLLLAVSLVLLYLY GTHSHGLFKKLGIPGPTPLPFLGNI LSYHKGFCMFDMECHKKYGKVWGFY DGQQPVLAITDPDMIKTVLVKECYS VFTNRRPFGPVGFMKSAISIAEDEE WKRLRSLLSPTFTSGKLKEMVPIIA QYGDVLVRNLRREAETGKPVTLKDV FGAYSMDVITSTSFGVNIDSLNNPQ DPFVENTKKLLRFDFLDPFFLSITV FPFLIPILEVLNICVFPREVTNFLR KSVKRMKESRLEDTQKHRVDFLQLM IDSQNSKETESHKALSDLELVAQSI IFIFAGYETTSSVLSFIMYELATHP DVQQKLQEEIDAVLPNKAPPTYDTV LQMEYLDMVVNETLRLFPIAMRLER VCKKDVEINGMFIPKGVVVMIPSYA LHRDPKYWTEPEKFLPERFSKKNKD NIDPYIYTPFGSGPRNCIGMRFALM NMKLALIRVLQNFSFKPCKETQIPL KLSLGGLLQPEKPVVLKVESRDGTV SGA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 [ Homo sapiens ]
Official Symbol : CYP3A4
Synonyms : CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; CYP3A3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680;
Gene ID : 1576
mRNA Refseq : NM_001202855
Protein Refseq : NP_001189784
MIM : 124010
UniProt ID : P08684

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◆ Lysates
CYP3A4-436HCL Recombinant Human CYP3A4 cell lysate +Inquiry

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◆ Assay kits
Kit-2142 Cytochrome P450 3A4 Inhibitor Screening Kit +Inquiry
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CYP3A4 contribute to inter-individual drug response variability? 02/13/2022

Variability in CYP3A4 activity due to genetic, environmental, and health factors results in diverse drug responses among individuals.

What is the impact of CYP3A4 inhibitors and inducers on drug effectiveness and safety? 01/07/2020

CYP3A4 inhibitors can increase, while inducers can decrease drug levels, affecting their safety and effectiveness.

Where is CYP3A4 most highly expressed? 09/09/2019

CYP3A4 is predominantly expressed in the liver and intestines.

What role does CYP3A4 play in drug metabolism? 04/03/2019

CYP3A4 is crucial for breaking down and clearing a wide variety of drugs and toxins from the body.

Are there common genetic polymorphisms in CYP3A4, and how do they affect enzyme activity? 01/23/2019

Genetic polymorphisms in CYP3A4 can result in altered enzyme activity, impacting drug metabolism.

How can CYP3A4-mediated drug interactions be managed? 01/02/2019

Managing CYP3A4-mediated interactions may involve using drug interaction databases, adjusting drug dosages, or choosing alternative medications.

How does CYP3A4 activity vary with age? 01/18/2018

CYP3A4 activity is generally lower in infants, peaks in childhood, and varies in adults.

Customer Reviews (3)

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Reviews
09/06/2021

    Superior quality, highly recommend.

    01/23/2020

      Worked well, as described.

      01/08/2020

        Perfect for protein studies.

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