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Recombinant Human DHODH Protein, GST-tagged

Cat.No. : DHODH-2590H
Product Overview : Human DHODH full-length ORF (1 a.a. - 165 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 43.9 kDa
AA Sequence : MVPSHSAPPVCLCSAGMDLTVTGFQ WWNTGYGPDSRSRPSSQKLGIDGLI VTNTTVSRPAGLQGALRSETGGLSG KPLRDLSTQTIREMYALTQGRVPII GVGGVSSRQDVLEKIRAGASLVQLY TALTFWGPPVVGKVKRELEALLKEQ GFGGVTDAIGADHRR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DHODH dihydroorotate dehydrogenase (quinone) [ Homo sapiens ]
Official Symbol : DHODH
Synonyms : DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; URA1; POADS; DHOdehase;
Gene ID : 1723
mRNA Refseq : NM_001361
Protein Refseq : NP_001352
MIM : 126064
UniProt ID : Q02127

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does DHODH contribute to pyrimidine biosynthesis? 08/28/2022

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism? 10/23/2020

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway? 10/27/2018

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth? 05/07/2018

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis? 12/29/2017

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases? 08/01/2017

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment? 07/17/2017

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.

Customer Reviews (3)

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Reviews
07/29/2020

    Saves time and effort. Highly recommended for research.

    11/03/2017

      Top-notch support for insights. Trusted for accurate data.

      05/05/2017

        Reliable data, essential for our protein research.

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