Recombinant Human DHODH Protein, GST-tagged
Cat.No. : | DHODH-2590H |
Product Overview : | Human DHODH full-length ORF (1 a.a. - 165 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 43.9 kDa |
AA Sequence : | MVPSHSAPPVCLCSAGMDLTVTGFQ WWNTGYGPDSRSRPSSQKLGIDGLI VTNTTVSRPAGLQGALRSETGGLSG KPLRDLSTQTIREMYALTQGRVPII GVGGVSSRQDVLEKIRAGASLVQLY TALTFWGPPVVGKVKRELEALLKEQ GFGGVTDAIGADHRR |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DHODH dihydroorotate dehydrogenase (quinone) [ Homo sapiens ] |
Official Symbol : | DHODH |
Synonyms : | DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; URA1; POADS; DHOdehase; |
Gene ID : | 1723 |
mRNA Refseq : | NM_001361 |
Protein Refseq : | NP_001352 |
MIM : | 126064 |
UniProt ID : | Q02127 |
Products Types
◆ Recombinant Protein | ||
Dhodh-2546M | Recombinant Mouse Dhodh Protein, Myc/DDK-tagged | +Inquiry |
DHODH-01H | Active Recombinant Human DHODH Protein, Met/His-tagged | +Inquiry |
DHODH-2355M | Recombinant Mouse DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
DHODH-1517R | Recombinant Rat DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
DHODH-2541M | Recombinant Mouse DHODH Protein (31-395 aa), His-tagged | +Inquiry |
◆ Lysates | ||
DHODH-6944HCL | Recombinant Human DHODH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.
DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.
DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.
DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.
Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.
Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.
Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.
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