Recombinant Human DHODH protein, GST-tagged
Cat.No. : | DHODH-11970H |
Product Overview : | Recombinant Human DHODH (1-395aa) protein was fused to GST-tag and expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
Molecular Mass : | 66 kDa |
Protein length : | 395aa |
AA Sequence : | MAWRHLKKRAQDAVIILGGGGLLFA SYLMATGDERFYAEHLMPTLQGLLD PESAHRLAVRFTSLGLLPRARFQDS DMLEVRVLGHKFRNPVGIAAGFDKH GEAVDGLYKMGFGFVEIGSVTPKPQ EGNPRPRVFRLPEDQAVINRYGFNS HGLSVVEHRLRARQQKQAKLTEDGL PLGVNLGKNKTSVDAAEDYAEGVRV LGPLADYLVVNVSSPNTAGLRSLQG KAELRRLLTKVLQERDGLRRVHRPA VLVKIAPDLTSQDKEDIASVVKELG IDGLIVTNTTVSRPAGLQGALRSET GGLSGKPLRDLSTQTIREMYALTQG RVPIIGVGGVSSGQDALEKIRAGAS LVQLYTALTFWGPPVVGKVKRELEA LLKEQGFGGVTDAIGADHRR |
Purity : | 85%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8 centigrade for (1-2 weeks). Long-term storage: Aliquot and store at -20 to -80 centigrade for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used). Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Gene Name : | DHODH |
Official Symbol : | DHODH |
Synonyms : | URA1; POADS; DHOdehase |
Gene ID : | 1723 |
mRNA Refseq : | NM_001361.5 |
Protein Refseq : | NP_001352.2 |
MIM : | 126064 |
UniProt ID : | Q02127 |
Products Types
◆ Recombinant Protein | ||
DHODH-01H | Active Recombinant Human DHODH Protein, Met/His-tagged | +Inquiry |
DHODH-1517R | Recombinant Rat DHODH Protein, His (Fc)-Avi-tagged | +Inquiry |
DHODH-2590H | Recombinant Human DHODH Protein, GST-tagged | +Inquiry |
DHODH-2541M | Recombinant Mouse DHODH Protein (31-395 aa), His-tagged | +Inquiry |
Dhodh-2546M | Recombinant Mouse Dhodh Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
DHODH-6944HCL | Recombinant Human DHODH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.
DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.
DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.
DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.
Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.
Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.
Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.
Customer Reviews (3)
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