Recombinant Human DHODH (30-395) Protein, His-tagged

• Cat.No.: DHODH15503H

Specification

• Description: DHODH (human) was expressed and purified from E. coli. The protein was expressed as a HIS-fusion protein and purified by a 3-step chromatographic procedure comprising affinity and size exclusion chromatography steps.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 40 kDa
• Purity: > 90%
• Storage: frozen; -80
• Storage Buffer: 50 mM HEPES 7.7;
  400 mM NaCl;
  30% Glycerol;
  1 mM EDTA;
  10 mM C11DAO

Gene Information

• Gene Name: DHODH (30-395)
• Official Symbol: DHODH
• Gene ID: 1723
• UniProt ID: Q02127

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Q&As

How does DHODH contribute to pyrimidine biosynthesis?

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism?

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway?

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth?

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis?

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases?

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment?

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.