Recombinant Human DPP4 Protein, His-tagged
Cat.No. : | DPP4-792H |
Product Overview : | Recombinant human DPP4 protein with His tag was expressed in HEK293. |
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Description : | The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | 85.4 kDa |
Protein length : | 766 |
AA Sequence : | MKTPWKVLLGLLGAAALVTIITVPV VLLNKGTDDATADSRKTYTLTDYLK NTYRLKLYSLRWISDHEYLYKQENN ILVFNAEYGNSSVFLENSTFDEFGH SINDYSISPDGQFILLEYNYVKQWR HSYTASYDIYDLNKRQLITEERIPN NTQWVTWSPVGHKLAYVWNNDIYVK IEPNLPSYRITWTGKEDIIYNGITD WVYEEEVFSAYSALWWSPNGTFLAY AQFNDTEVPLIEYSFYSDESLQYPK TVRVPYPKAGAVNPTVKFFVVNTDS LSSVTNATSIQITAPASMLIGDHYL CDVTWATQERISLQWLRRIQNYSVM DICDYDESSGRWNCLVARQHIEMST TGWVGRFRPSEPHFTLDGNSFYKII SNEEGYRHICYFQIDKKDCTFITKG TWEVIGIEALTSDYLYYISNEYKGM PGGRNLYKIQLSDYTKVTCLSCELN PERCQYYSVSFSKEAKYYQLRCSGP GLPLYTLHSSVNDKGLRVLEDNSAL DKMLQNVQMPSKKLDFIILNETKFW YQMILPPHFDKSKKYPLLLDVYAGP CSQKADTVFRLNWATYLASTENIIV ASFDGRGSGYQGDKIMHAINRRLGT FEVEDQIEAARQFSKMGFVDNKRIA IWGWSYGGYVTSMVLGSGSGVFKCG IAVAPVSRWEYYDSVYTERYMGLPT PEDNLDHYRNSTVMSRAENFKQVEY LLIHGTADDNVHFQQSAQISKALVD VGVDFQAMWYTDEDHGIASSTAHQH IYTHMSHFIKQCFSLP |
Purity : | > 98% |
Applications : | WB; ELISA; FACS; FC |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade. |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | DPP4 dipeptidyl-peptidase 4 [ Homo sapiens (human) ] |
Official Symbol : | DPP4 |
Synonyms : | DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103; |
Gene ID : | 1803 |
mRNA Refseq : | NM_001935 |
Protein Refseq : | NP_001926 |
MIM : | 102720 |
UniProt ID : | P27487 |
Products Types
◆ Recombinant Protein | ||
DPP4-5879H | Recombinant Human DPP4 protein, hFc-Flag&Myc-tagged | +Inquiry |
DPP4-7872H | Recombinant Human DPP4 protein(Ser484~Val728), His-tagged | +Inquiry |
DPP4-2845H | Recombinant Human DPP4 Protein, GST-tagged | +Inquiry |
Dpp4-2503M | Recombinant Mouse Dpp4 Protein, His (Fc)-Avi-tagged | +Inquiry |
DPP4-116H | Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
DPP4-197H | Native Human Dipeptidyl Peptidase IV | +Inquiry |
DPP4-31H | Active Native Human Dipeptidyl Peptidase-IV | +Inquiry |
◆ Lysates | ||
DPP4-2979HCL | Recombinant Human DPP4 cell lysate | +Inquiry |
DPP4-733CCL | Recombinant Cynomolgus DPP4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0314 | DPP4 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0313 | DPP IV Immunocapture Activity Assay Kit | +Inquiry |
Kit-0312 | Dipeptidyl peptidase IV Inhibitor Screening Assay Kit | +Inquiry |
Kit-0315 | DPP4 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.
By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.
Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.
Q&As (5)
Ask a questionDPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.
Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.
Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.
DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.
DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.
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