DPP4
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Official Full Name
dipeptidyl-peptidase 4
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Background
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008] -
Synonyms
DPP4; dipeptidyl-peptidase 4; CD26; ADABP; ADCP2; DPPIV; TP103; dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);
- Involved Pathway
- Protein Function
- Interacting Protein
- DPP4 Related Articles
- DPP4 Related Research Area
DPP4 involved in several pathways and played different roles in them. We selected most pathways DPP4 participated on our site, such as Incretin synthesis, secretion, and inactivation, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Incretin synthesis, secretion, and inactivation | GRP;SLC38A8;PCSK1;O3far1;CDX2;DPP4;GPR120;SPCS3;GPR119 |
| Metabolism of proteins | DNAJC19;ATP6AP2;CNIH2;ADAMTS13;CNIH;IGFBP1B;ADAMTS3;NAPG;MUC20 |
| Peptide hormone metabolism | CDX2;GPR120;GRP;SLC30A6;O3far1;CPB2;BCHE;SLC30A5;GPR119 |
| Protein digestion and absorption | ATP1B4;MME;MEP1A;KCNQ1;ATP1A3;KCNE3;SLC3A2;ATP1B1;ATP1A1 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | DPP4;GPR119;PCSK1 |
DPP4 has several biochemical functions, for example, dipeptidyl-peptidase activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP4 itself. We selected most functions DPP4 had, and list some proteins which have the same functions with DPP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dipeptidyl-peptidase activity | DPP3;DPP4;DPP8;DPEP3;DPEP1;NAALAD2;DPP7;PRCP;FAP |
| identical protein binding | PSME3;LDHB;STK4;INHBA;SH3BP4;STAT6;CRYAB;CLDN1;TNF |
| protease binding | MBP;RFFL;SELL;BCL10;DVL3;MBL1;XBP1;FAP;POLG |
| protein binding | SLC35A2;FAM20A;TSPAN4;TRIM44;CDCA5;ADRB2;RB1CC1;NKG7;ATG4A |
| protein homodimerization activity | ADD1;CADM2A;P2RX4;IL17F;ERP29;CAMK2B;CCBL2;IKZF3;CUBN |
| receptor binding | WNT4B;BAAT;SRI;FGF8A;CXCL1;NRG2;SMARCD3;ALCAM;PLXNC1 |
| serine-type endopeptidase activity | PRSS7;KLK1B11;RHBDD2;PRSS44;CELA3A;KLK1;PRSS22;KLK1B4;PRSS41 |
| serine-type peptidase activity | F9B;PRSS41;KLK10;TPSB2;KLK1B9;PRSS16;F7;TPSAB1;PRSS30 |
| virus receptor activity | CD86;TNFRSF4;ITGB7;AXL;SCARB1;ITGAV;CXCR4;SLC10A1;SELPLG |
DPP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP4.
CXCL11; CXCL10; CXCL2; CCL11; CXCL9
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