| Description : |
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.2 kDa |
| AA Sequence : |
MTTAKEPSASGKSVQQQEQELVGSN PPQRNWKGIAIALLVILVICSLIVT SVILLTPAEDNSLSQKKKVTVEDLF SEDFKIHDPEAKWISDTEFIYREQK GTVRLWNVETNTSTVLIEGKKIESL RAIRYEISPDREYALFSYNVEPIYQ HSYTGYYVLSKIPHGDPQSLDPPEV SNAKLQYAGWGPKGQQLIFIFENNI YYCAHVGKQAIRVVSTGKEGVIYNG LSDWLYEEEILKTHIAHWWSPDGTR LAYAAINDSRVPIMELPTYTGSIYP TVKPYHYPKAGSENPSISLHVIGLN GPTHDLEMMPPDDPRMREYYITMVK WATSTKVAVTWLNRAQNVSILTLCD ATTGVCTKKHEDESEAWLHRQNEEP VFSKDGRKFFFIRAIPQGGRGKFYH ITVSSSQPNSSNDNIQSITSGDWDV TKILAYDEKGNKIYFLSTEDLPRRR QLYSANTVGNFNRQCLSCDLVENCT YFSASFSHSMDFFLLKCEGPGVPMV TVHNTTDKKKMFDLETNEHVKKAIN DRQMPKVEYRDIEIDDYNLPMQILK PATFTDTTHYPLLLVVDGTPGSQSV AEKFEVSWETVMVSSHGAVVVKCDG RGSGFQGTKLLHEVRRRLGLLEEKD QMEAVRTMLKEQYIDRTRVAVFGKD YGGYLSTYILPAKGENQGQTFTCGS ALSPITDFKLYASAFSERYLGLHGL DNRAYEMTKVAHRVSALEEQQFLII HPTADEKIHFQHTAELITQLIRGKA NYSLQIYPDESHYFTSSSLKQHLYR SIINFFVECFRIQDKLLTVTAKEDE EEDTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
