Recombinant Human EIF3E Protein (1-445 aa), GST-tagged
Cat.No. : | EIF3E-2115H |
Product Overview : | Recombinant Human EIF3E Protein (1-445 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length. |
- Specification
- Gene Information
- Related Products
Description : | omponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway . May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 79.1 kDa |
Protein length : | 1-445 aa |
AA Sequence : | MAEYDLTTRIAHFLDRHLVFPLLEF LSVKEIYNEKELLQGKLDLLSDTNM VDFAMDVYKNLYSDDIPHALREKRT TVVAQLKQLQAETEPIVKMFEDPET TRQMQSTRDGRMLFDYLADKHGFRQ EYLDTLYRYAKFQYECGNYSGAAEY LYFFRVLVPATDRNALSSLWGKLAS EILMQNWDAAMEDLTRLKETIDNNS VSSPLQSLQQRTWLIHWSLFVFFNH PKGRDNIIDLFLYQPQYLNAIQTMC PHILRYLTTAVITNKDVRKRRQVLK DLVKVIQQESYTYKDPITEFVECLY VNFDFDGAQKKLRECESVLVNDFFL VACLEDFIENARLFIFETFCRIHQC ISINMLADKLNMTPEEAERWIVNLI RNARLDAKIDSKLGHVVMGNNAVSP YQQVIEKTKSLSFRSQMLAMNIEKK LNQNSRSEAPNWATQDSGFY |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | EIF3E eukaryotic translation initiation factor 3, subunit E [ Homo sapiens ] |
Official Symbol : | EIF3E |
Synonyms : | EIF3E; eIF3 p48; eIF3e; eIF-3 p48; INT6; EIF3S6; EIF3-P48; eIF3-p46; |
Gene ID : | 3646 |
mRNA Refseq : | NM_001568 |
Protein Refseq : | NP_001559 |
MIM : | 602210 |
UniProt ID : | P60228 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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