Recombinant Human F13A1 Protein, GST-tagged

• Cat.No.: F13A1-3609H
• Product Overview: Human F13A1 full-length ORF ( AAH27963, 1 a.a. - 732 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 106.26 kDa
• AA Sequence: MSETSRTAFGGRRAVPPNNSNAAED DLPTVELQGVVPRGVNLQEFLNATS VHLFKERWDTNKVDHHTDKYENNKL IVRRGQSFYVQIDFSRPYDPRRDLF RVEYVIGRYPQENKGTYIPVPIVSE LQSGKWGAKIVMREDRSVRLSIQSS PKCIVGKFRMYVAVWTPYGVLRTSR NPETDTYILFNPWCEDDAVYLDNEK EREEYVLNDIGVIFYGEVNDIKTRS WSYGQFEDGILDTCLYVMDRAQMDL SGRGNPIKVSRVGSAMVNAKDDEGV LVGSWDNIYAYGVPPSAWTGSVDIL LEYRSSENPVRYGQCWVFAGVFNTF LRCLGIPARIVTNYFSAHDNDANLQ MDIFLEEDGNVNSKLTKDSVWNYHC WNEAWMTRPDLPVGFGGWQAVDSTP QENSDGMYRCGPASVQAIKHGHVCF QFDAPFVFAEVNSDLIYITAKKDGT HVVENVDATHIGKLIVTKQIGGDGM MDITDTYKFQEGQEEERLALETALM YGAKKPLNTEGVMKSRSNVDMDFEV ENAVLGKDFKLSITFRNNSHNRYTI TAYLSANITFYTGVPKAEFKKETFD VTLEPLSFKKEAVLIQAGEYMGQLL EQASLHFFVTARINETRDVLAKQKS TVLTIPEIIIKVRGTQVVGSDMTVI VEFTNPLKETLRNVWVHLDGPGVTR PMKKMFREIRPNSTVQWEEVCRPWV SGHRKLIASMSSDSLRHVYGELDVQ IQRRPSM
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: F13A1 coagulation factor XIII, A1 polypeptide [ Homo sapiens ]
• Official Symbol: F13A1
• Synonyms: F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide)
• Gene ID: 2162
• mRNA Refseq: NM_000129
• Protein Refseq: NP_000120
• MIM: 134570
• UniProt ID: P00488