Recombinant Human F8, GST-tagged
Cat.No. : | F8-126H |
Product Overview : | Recombinant Human F8 (1 a.a. - 216 a.a.) fused with GST-tag at N-terminal, was expressed in vitro wheat germ expression system. |
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Cat. No. : | F8-126H |
Description : | This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. |
Source : | wheat germ |
Molecular Mass : | 51 kDa |
Sequence : | MRIQDPGKVFFGNVDSSGIKHNIFN PPIIARYIRLHPTHYSIRSTLRMEL MGCDLNSCSMPLGMESKAISDAQIT ASSYFTNMFATWSPSKARLHLQGRS NAWRPQVNNPKEWLQVDFQKTMKVT GVTTQGVKSLLTSMYVKEFLISSSQ DGHQWTLFFQNGKVKVFQGNQDSFT PVVNSLDPPLLTRYLRIHPQSWVHQ IALRMEVLGCEAQDLY |
Purification : | Glutathione Sepharose 4 Fast Flow |
Storage buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer. |
Applications : | ELISA; WB |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Note : | Best use within three months from the date of receipt of this protein. |
OfficialSymbol : | F8 |
Tag : | Non |
Gene Name : | F8 coagulation factor VIII, procoagulant component [ Homo sapiens ] |
Synonyms : | F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; Factor VIIIF8B; hemophilia A; Antihemophilic factor; Procoagulant component; coagulation factor VIII; coagulation factor VIIIc; coagulation factor VIII; OTTHUMP00000061446; OTTHUMP00000196174; Coagulation factor VIII; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain |
Gene ID : | 2157 |
mRNA Refseq : | NM_019863 |
Protein Refseq : | NP_063916 |
MIM : | 300841 |
UniProt ID : | P00451 |
Chromosome Location : | Xq28 |
Pathway : | Complement and coagulation cascades; Hemostasis |
Function : | copper ion binding; oxidoreductase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
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F8-912C | Recombinant Cattle F8 Protein, His-tagged | +Inquiry |
F8-1454H | Recombinant Human F8 Protein, His-tagged | +Inquiry |
F8-1453M | Recombinant Mouse F8 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
F8-6482HCL | Recombinant Human F8 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Q&As (5)
Ask a questionRecombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.
Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.
Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.
Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.
In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.
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