Recombinant Human FAP Protein, GST-tagged

Cat.No. : FAP-3836H
Product Overview : Human FAP full-length ORF ( NP_004451.2, 1 a.a. - 760 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 114.1 kDa
AA Sequence : MKTWVKIVFGVATSAVLALLVMCIV LRPSRVHNSEENTMRALTLKDILNG TFSYKTFFPNWISGQEYLHQSADNN IVLYNIETGQSYTILSNRTMKSVNA SNYGLSPDRQFVYLESDYSKLWRYS YTATYYIYDLSNGEFVRGNELPRPI QYLCWSPVGSKLAYVYQNNIYLKQR PGDPPFQITFNGRENKIFNGIPDWV YEEEMLATKYALWWSPNGKFLAYAE FNDTDIPVIAYSYYGDEQYPRTINI PYPKAGAKNPVVRIFIIDTTYPAYV GPQEVPVPAMIASSDYYFSWLTWVT DERVCLQWLKRVQNVSVLSICDFRE DWQTWDCPKTQEHIEESRTGWAGGF FVSTPVFSYDAISYYKIFSDKDGYK HIHYIKDTVENAIQITSGKWEAINI FRVTQDSLFYSSNEFEEYPGRRNIY RISIGSYPPSKKCVTCHLRKERCQY YTASFSDYAKYYALVCYGPGIPIST LHDGRTDQEIKILEENKELENALKN IQLPKEEIKKLEVDEITLWYKMILP PQFDRSKKYPLLIQVYGGPCSQSVR SVFAVNWISYLASKEGMVIALVDGR GTAFQGDKLLYAVYRKLGVYEVEDQ ITAVRKFIEMGFIDEKRIAIWGWSY GGYVSSLALASGTGLFKCGIAVAPV SSWEYYASVYTERFMGLPTKDDNLE HYKNSTVMARAEYFRNVDYLLIHGT ADDNVHFQNSAQIAKALVNAQVDFQ AMWYSDQNHGLSGLSTNHLYTHMTH FLKQCFSLSD
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
SDS-PAGE: 12.5% SDS-PAGE Stained with Coomassie Blue.
Gene Name : FAP fibroblast activation protein, alpha [ Homo sapiens ]
Official Symbol : FAP
Synonyms : FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;
Gene ID : 2191
mRNA Refseq : NM_004460
Protein Refseq : NP_004451
MIM : 600403
UniProt ID : Q12884

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FAP contribute to immunosuppression in the tumor microenvironment? 04/18/2023

FAP can suppress the immune response by modulating the activity of certain immune cells, creating an immunosuppressive tumor microenvironment.

How can FAP expression be used as a prognostic marker in cancer patients? 02/03/2023

High levels of FAP expression in tumors have been associated with poor prognosis, making it a potential prognostic marker for certain cancers.

Are there ongoing clinical trials exploring FAP-targeted therapies? 05/04/2021

Yes, several clinical trials are investigating the safety and efficacy of FAP-targeted therapies in various cancer types.

Can FAP be utilized as a therapeutic target beyond cancer treatment? 11/19/2020

FAP-targeted therapies are being explored for conditions such as fibrotic diseases and rheumatoid arthritis, extending its potential clinical applications.

How is imaging technology utilized to detect FAP expression in tumors? 09/17/2018

Molecular imaging techniques, such as positron emission tomography (PET), can be employed to visualize FAP expression in tumors noninvasively.

Customer Reviews (3)

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Reviews
08/11/2020

    It enables accurate detection and quantification of FAP protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

    05/04/2020

      FAP protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      01/02/2019

        FAP protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

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