Recombinant Human FGF21 Protein, His-tagged

Cat.No. : FGF21-930H
Product Overview : Recombinant Human FGF21 Protein (His29-Ser209) with His tag was expressed in 293F.
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Description : Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue.
Source : HEK293F
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 21.0 kDa; Accurate Molecular Mass: 27 kDa
Protein length : His29-Ser209
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
SDS-PAGE:
Gene Name : FGF21 fibroblast growth factor 21 [ Homo sapiens (human) ]
Official Symbol : FGF21
Synonyms : FGF21; fibroblast growth factor 21; FGF-21;
Gene ID : 26291
mRNA Refseq : NM_019113
Protein Refseq : NP_061986
MIM : 609436
UniProt ID : Q9NSA1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FGF21 expression regulated in adipose tissue? 10/31/2022

FGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.

What are the effects of FGF21 on lipid metabolism? 08/27/2020

FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.

Can FGF21 be a biomarker for metabolic health? 08/07/2019

FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.

Is FGF21 involved in the regulation of insulin sensitivity? 03/03/2019

Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.

Does FGF21 have roles in energy expenditure? 11/11/2018

Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.

Are there gender-specific differences in FGF21 levels? 08/30/2017

Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.

What signaling pathways does FGF21 activate? 01/09/2016

FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.

Customer Reviews (3)

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Reviews
01/04/2022

    The manufacturer's history of producing high-quality products contributed to our trust in this protein.

    06/27/2021

      Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

      03/03/2016

        The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

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