Recombinant Human FGL2 Protein, GST-tagged

• Cat.No.: FGL2-4153H
• Product Overview: Human FGL2 full-length ORF ( NP_006673.1, 1 a.a. - 439 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 76.6 kDa
• AA Sequence: MKLANWYWLSSAVLATYGFLVVANN ETEEIKDERAKDVCPVRLESRGKCE EAGECPYQVSLPPLTIQLPKQFSRI EEVFKEVQNLKEIVNSLKKSCQDCK LQADDNGDPGRNGLLLPSTGAPGEV GDNRVRELESEVNKLSSELKNAKEE INVLHGRLEKLNLVNMNNIENYVDS KVANLTFVVNSLDGKCSKCPSQEQI QSRPVQHLIYKDCSDYYAIGKRSSE TYRVTPDPKNSSFEVYCDMETMGGG WTVLQARLDGSTNFTRTWQDYKAGF GNLRREFWLGNDKIHLLTKSKEMIL RIDLEDFNGVELYALYDQFYVANEF LKYRLHVGNYNGTAGDALRFNKHYN HDLKFFTTPDKDNDRYPSGNCGLYY SSGWWFDACLSANLNGKYYHQKYRG VRNGIFWGTWPGVSEAHPGGYKSSF KEAKMMIRPKHFKP
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FGL2 fibrinogen-like 2 [ Homo sapiens ]
• Official Symbol: FGL2
• Synonyms: FGL2; fibrinogen-like 2; fibroleukin; pT49; T49; fibrinogen-like protein 2
• Gene ID: 10875
• mRNA Refseq: NM_006682
• Protein Refseq: NP_006673
• MIM: 605351
• UniProt ID: Q14314

Reviews

11/17/2022

By utilizing the FGL2 protein, I can approach my research with unwavering confidence in its quality, along with the unparalleled support provided by its manufacturer.

04/13/2021

Their expertise and prompt responsiveness exemplify their dedication to providing customers with solutions and guidance.

08/16/2020

The FGL2 protein offers exceptional quality that seamlessly aligns with my experimental requirements.

Q&As

Is FGL2 protein a potential therapeutic target for autoimmune diseases?

Yes, targeting FGL2 protein has shown promise in preclinical studies as a potential therapeutic strategy for autoimmune diseases.

How does FGL2 protein contribute to liver diseases?

FGL2 protein has been implicated in liver fibrosis, cirrhosis, and hepatocellular carcinoma by promoting inflammation, fibrogenesis, and immune dysregulation.

What are the potential side effects of targeting FGL2 protein for therapy?

Potential side effects may include immunosuppression, increased risk of infections, and dysregulation of immune homeostasis.

What are the current methods for detecting FGL2 protein in clinical samples?

Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry are commonly used methods for detecting FGL2 protein in clinical samples.

How is FGL2 protein involved in cancer progression?

FGL2 protein has been shown to promote cancer cell growth, invasion, and metastasis by modulating immune responses and promoting angiogenesis.