Recombinant Human FUT8

• Cat.No.: FUT8-27230TH
• Product Overview: Recombinant full length Human FUT8 with N terminal proprietary tag, predicted mwt: 89.32 kDa.

Specification

• Description: This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
• Protein length: 575 amino acids
• Molecular Weight: 89.320kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSS RELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGPAI GRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIE NGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHE RSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQN PKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRT LILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGE VKDKNVQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVH GDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVI GVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVD KKRVYLATDDPSLLKEAKTKYPNYEFISDNSISWSAGLHN RYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQ TLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADE IPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVRE KIETVKYPTYPEAEK
• Sequence Similarities: Belongs to the glycosyltransferase 23 family.Contains 1 SH3 domain.

Gene Information

• Gene Name: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) [ Homo sapiens ]
• Official Symbol: FUT8
• Synonyms: FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); alpha-(1,6)-fucosyltransferase
• Gene ID: 2530
• mRNA Refseq: NM_004480
• Protein Refseq: NP_004471
• MIM: 602589
• Uniprot ID: Q9BYC5
• Chromosome Location: 14q24.3
• Pathway: Asparagine N-linked glycosylation, organism-specific biosystem; Glycosaminoglycan biosynthesis - keratan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - keratan sulfate, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem
• Function: SH3 domain binding; glycoprotein 6-alpha-L-fucosyltransferase activity; transferase activity, transferring glycosyl groups