Recombinant Human GCSH Protein, Myc/DDK-tagged, C13 and N15-labeled GCSH-6266H

Recombinant Human GCSH Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human GCSH Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : GCSH-6266H
Product Overview : GCSH MS Standard C13 and N15-labeled recombinant protein (NP_004474) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 18.91 kDa
AA Sequence : MALRVVRSVR ALLCTLRAVP LPAAPCPPRP WQLGVGAVRT LRTGPALLSV RKFTEKHEWV TTENGIGTVG ISNFAQEALG DVVYCSLPEV GTKLNKQDEF GALESVKAAS ELYSPLSGEV TEINEALAEN PGLVNKSCYE DGWLIKMTLS NPSELDELMS EEAYEKYIKS IEETRTRPLE QKLISEEDLA ANDILDYKDD DDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : GCSH glycine cleavage system protein H [ Homo sapiens (human) ]
Official Symbol : GCSH
Synonyms : GCSH; glycine cleavage system protein H (aminomethyl carrier); glycine cleavage system H protein, mitochondrial; lipoic acid containing protein; lipoic acid-containing protein; mitochondrial glycine cleavage system H-protein; GCE; NKH;
Gene ID : 2653
mRNA Refseq : NM_004483
Protein Refseq : NP_004474
MIM : 238330
UniProt ID : P23434
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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