Recombinant Human GFRA1 Protein, GST-tagged

• Cat.No.: GFRA1-4860H
• Product Overview: Human GFRA1 full-length ORF ( NP_665736.1, 1 a.a. - 460 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 77.2 kDa
• AA Sequence: MFLATLYFALPLLDLLLSAEVSGGD RLDCVKASDQCLKEQSCSTKYRTLR QCVAGKETNFSLASGLEAKDECRSA MEALKQKSLYNCRCKRGMKKEKNCL RIYWSMYQSLQGNDLLEDSPYEPVN SRLSDIFRVVPFISVEHIPKGNNCL DAAKACNLDDICKKYRSAYITPCTT SVSNDVCNRRKCHKALRQFFDKVPA KHSYGMLFCSCRDIACTERRRQTIV PVCSYEEREKPNCLNLQDSCKTNYI CRSRLADFFTNCQPESRSVSSCLKE NYADCLLAYSGLIGTVMTPNYIDSS SLSVAPWCDCSNSGNDLEECLKFLN FFKDNTCLKNAIQAFGNGSDVTVWQ PAFPVQTTTATTTTALRVKNKPLGP AGSENEIPTHVLPPCANLQAQKLKS NVSGNTHLCISNGNYEKEGLGASSH ITTKSMAAPPSCGLSPLLVLVVTAL STLLSLTETS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GFRA1 GDNF family receptor alpha 1 [ Homo sapiens ]
• Official Symbol: GFRA1
• Synonyms: GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; GFR-ALPHA-1; FLJ10561; FLJ31546; MGC23045; DKFZp313E1012; DKFZp686J0156
• Gene ID: 2674
• mRNA Refseq: NM_001145453
• Protein Refseq: NP_001138925
• MIM: 601496
• UniProt ID: P56159