Recombinant Human GMCSF/IL-3 Fusion Protein
Cat.No. : | IL3-88H |
Product Overview : | Recombinant Human GMCSF/IL3 fusion protein produced in E.Coli is a single, non-glycosylated, polypeptide chain having a Mw of 30kD. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL3-88H |
Description : | The analog of GMCSF/IL3 is PIXY321. Results indicate that PIXY321 can stimulate multilineage hematopoiesis in vivo and enhance neutrophil and platelet recovery following chemotherapy and bone marrow transplantation (BMT). These results suggest that PIXY321 elicits the biological effects of both its component cytokines and represents a novel means of delivering two independent but interactive cytokines in combination. PIXY321 is purified by proprietary chromatographic techniques. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (c) Analysis by SDS-PAGE. |
Formulation : | The protein was lyophilized after extensive dialysis against 10 mM PBS, pH= 7.4±0.1 and 0.1% BSA. |
Solubility : | It is recommended to reconstitute the lyophilized PIXY321 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Specific Activity : | The ED50as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line) is < 0.2 ng/ml, corresponding to a Specific Activity of 5 x106IU/mg. |
Stability : | Lyophilized PIXY321although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution PIXY321should be stored at 4℃ between 2-7 days and for future use below -18℃. Please prevent freeze-thaw cycles. |
Synonyms : | PIXY321; GMCSF/ IL3 |
Synonyms : | PIXY321; GMCSF/ IL3 |
Products Types
◆ Recombinant Protein | ||
IL3-435H | Active Recombinant Human IL3 protein(Met1-Phe152), His-tagged | +Inquiry |
Il3-027I | Active Recombinant Mouse Il3 Protein (135 aa) | +Inquiry |
Il3-188M | Recombinant Active Mouse IL3 Protein, His-tagged(C-ter) | +Inquiry |
IL3-4369B | Recombinant Bovine IL3 Protein | +Inquiry |
IL3-097I | Active Recombinant Human IL3 Protein (133 aa) | +Inquiry |
◆ Lysates | ||
IL3-607HCL | Recombinant Human IL3 cell lysate | +Inquiry |
IL3-445RCL | Recombinant Rat IL3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (16)
Ask a questionIn vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.
Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.
mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells
Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.
Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.
non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.
Such as allergic inflammation and parasitic infestation.
IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.
Bhlhe40
E.g., lymphocytes,epithelial cells, and fibroblasts
Yes, there are some completed clinical trials on IL3 results, but the specific results need to refer to the relevant research papers.
This protein can promote stem cell proliferation and differentiation during hematopoietic process, thus increasing the production of different types of blood cells.
In general, the IL3 has relatively few side effects, but some unpleasant symptoms such as fever, headache and nausea may occur.
IL3 can regulate the body's immune response and the function of immune cells, and plays an important role in immune regulation.
IL3 generally have good solubility and stability, making them easier to handle during drug preparation and storage.
The study of IL3 is ongoing, including its application in the development of therapeutic drugs, as well as in combination therapy with other immune molecules.
Customer Reviews (3)
Write a reviewI've used many brands, but this one is one of my favorites.
The performance is very stable and the price is very reasonable. I would definitely buy this product again.
I have recommended this brand to my colleagues and friends, and they all praise this product.
Ask a Question for All IL3 Products
Required fields are marked with *
My Review for All IL3 Products
Required fields are marked with *
Inquiry Basket