IL3 Protein

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IL3

Official Full Name	interleukin 3
Background	The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Synonyms	Colony stimulating factor multiple; Hematopoietic growth factor; IL 3; IL-3; IL3; IL3_HUMAN; Interleukin 3 (colony stimulating factor, multiple); Interleukin 3; Interleukin-3; Mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; Multipotential colony stimulating factor; Multipotential colony-stimulating factor; OTTHUMP00000065963; P cell stimulating factor; P-cell-stimulating factor; BPA; PSF; HCGF; Csfmu; nterleukin-3; TTMUSP00000005831; ast cell growth factor

Species :
Bovine
Canine
Chicken
Dog
Human
Mouse
Rat
Rhesus
Rhesus Macaque

Source :
CHO
E. coli
E.coli
HEK293
HEK293F
Hordeum Vulgare
Insect Cell
Mammalian Cell
Mouse
Nicotiana Benthamiana
S.cerevisiae
Wheat Germ
Yeast

Tag :
GST
His
T7
His-Avi
HQ
Met
N/A
N-His

Species	Cat.#	Product name	Source (Host)	Tag
Human	CSF3&IL3-5H	Recombinant Human GM-CSF/IL-3 (PIXY321) Fusion Protein	E.coli	N/A
Human	IL3-08H	Recombinant Human IL3 protein	E.coli	N/A
Human	IL3-120H	Recombinant Human Interleukin 3 (Colony-stimulating Factor, Multiple)	HEK293	N/A
Human	IL3-132H	Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), His-tagged	Insect Cell	His
Human	IL3-145H	Recombinant Human IL3 Active, His-tagged	Nicotiana Benthamiana	His
Human	IL3-1556H	Recombinant human IL3, Active, His-tagged	Nicotiana Benthamiana	His
Human	IL3-200H	Recombinant Human IL3	CHO	N/A
Human	IL3-275H	Recombinant Human Interleukin 3 (Colony-Stimulating Factor, Multiple)	S.cerevisiae	N/A
Human	IL3-378H	Recombinant Human IL3, His tagged	Insect Cell	His
Human	IL3-435H	Recombinant Human IL3 Protein, His-tagged	HEK293	His
Human	IL3-436H	Recombinant Human IL3 Protein	E.coli	N/A
Human	IL3-503H	Recombinant Human IL3	HEK293	N/A
Human	IL3-56H	Recombinant Human IL3, His-tagged	E.coli	His
Human	IL3-604H	Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged	Hordeum Vulgare	HQ
Human	IL3-639H	Recombinant Human IL3 protein, His & GST-tagged	E.coli	His/GST
Human	IL3-8862H	Recombinant Human IL3, His-tagged	Hordeum Vulgare	N/A
Human	IL3-88H	Recombinant Human GMCSF/IL-3 Fusion Protein	E.coli	N/A
Mouse	Il3-09M	Recombinant Mouse Il3 protein	E.coli	N/A
Mouse	Il3-366M	Recombinant Mouse Il3 Protein, His-tagged	Insect Cell	His
Mouse	Il3-592M	Recombinant Mouse Interleukin 3	Mouse	N/A
Mouse	Il3-640M	Recombinant Mouse Il3 protein, His & T7-tagged	E.coli	His/T7
Mouse	Il3-641M	Recombinant Mouse Il3 protein, His & GST-tagged	E.coli	His/GST
Mouse	Il3-644M	Recombinant Mouse Il3	E.coli	Met
Mouse	ll3-542M	Recombinant Mouse Iterleukin 3	Mouse	N/A
Rat	IL3-1093R	Recombinant Rat IL3 Protein, His-tagged	Insect Cell	His
Rat	Il3-576R	Recombinant Rat Il3 protein	E.coli	N/A
Rat	Il3-591R	Recombinant Rat Interleukin 3	E.coli	N/A
Rat	Il3-642R	Recombinant Rat Il3 protein, His & T7-tagged	E.coli	His/T7
Rat	Il3-643R	Recombinant Rat Il3 protein, His & GST-tagged	E.coli	His/GST
Rhesus Macaque	IL3-2250R	Recombinant Rhesus monkey IL3 Protein, His-tagged	Mammalian Cell	His
Rhesus	IL3-539R	Recombinant Rhesus IL3 protein	E.coli	N/A
Dog	IL3-362D	Recombinant Dog Interleukin 3 (colony-stimulating factor, multiple)	E.coli	N/A
Canine	IL3-407D	Recombinant Canine IL3 protein	E.coli	N/A
Chicken	IL3-1734C	Recombinant Chicken IL3	Mammalian Cell	His
Human	IL3-607HCL	Recombinant Human IL3 cell lysate	Insect Cell	N/A
Rat	IL3-445RCL	Recombinant Rat IL3 cell lysate	Insect Cell	N/A
Human	IL3-065H	Recombinant Human IL3 Protein	E. coli
Human	IL3-075HG	GMP Recombinant Human IL3 protein	E.coli	N/A
Human	IL3-07H	Recombinant Human IL3 Protein, Pre-aliquoted	E.coli
Dog	IL3-1035D	Recombinant Dog IL3 Protein, His-tagged	E.coli	N-His
Human	IL3-1036H	Recombinant Human IL3 Protein, His-tagged	HEK293F	N-His
Rat	Il3-1037R	Recombinant Rat Il3 Protein, His-tagged	HEK293F	N-His
Human	IL3-3102H	Recombinant Human IL3 protein, GST-tagged	E.coli	GST
Human	IL3-077HG	GMP Recombinant Human IL-3 protein, His-tagged	HEK293	His
Human	IL3-106H	Human Interleukin-3 (rDNA derived) Reference standard		N/A
Human	IL3-131H	Recombinant Human IL3 protein, His-Avi-tagged	HEK293	His-Avi
Human	IL3-132HG	GMP Recombinant Human IL3 protein	E.coli	N/A
Human	Il3-1922H	Recombinant Human Il3 Protein	Insect Cell	N/A
Human	IL3-5192H	Recombinant Human IL3 Protein, GST-tagged	Wheat Germ	GST
Mouse	Il3-107M	Recombinant Mouse Il3 Protein	E.coli
Mouse	Il3-108M	Recombinant Mouse Il3 Protein	E.coli
Mouse	Il3-114M	Mouse Interleukin-3 (rDNA derived) Reference standard		N/A
Mouse	IL3-455M	Recombinant Mouse IL3 Protein	HEK293	N/A
Mouse	Il3-7242M	Recombinant Mouse Il3 Protein, His-tagged	Insect Cell	His
Bovine	IL3-4369B	Recombinant Bovine IL3 Protein	Yeast	N/A

Involved Pathway Protein Function Interacting Protein IL3 Related Articles IL3 Related Gene Family

IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	CXCL2; ACVR1; IL12RB1; CXCL9; TNFSF11; GM2002; CSF1; IL9R; OSMR; TNF
PIK-Akt signaling pathway	IFNA12; IFNA7; PRLR; ITGAV; PPP2R2C; ITGA8; RELA; FGF10; TCL1B1; VEGFC
Apoptosis	PRKAR2B; Fasl; PIK3CD; STK26; DNM1L; PIK3R5; CASP2; ATM; AKT3A; AKT2
Jak-STAT signaling pathway	OSM; IL22RA1; STAT5A; IL4; BCL2A; MCL1; IL19; GRB2B; FHL1B; FHL1A
Hematopoietic cell lineage	IL11RA2; CD3E; CD3D; ITGA2; ITGA5; EPOR; IL6R; HLA-DRB4; IL1B; GM13305; IL7R
Fc epsilon RI signaling pathway	GRB2; IL13; VAV1; FYN; MAPK10; MS4A2; MAP2K2; LAT; PIK3R2; MAP2K1
Transcriptional misregulation in cancer	BIRC3; HIST1H3H; HIST1H3A; TRAF1; MET; SUPT3H; HMGA2; MLLT3; HOXA10; TCF3
Asthma	HLA-DQA2; RNASE3; EPX; HLA-DOB; IL13; PRG2; HLA-DRB4; HLA-DMB; CCL11; HLA-DMA

IL3 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.

Function	Related Protein
cytokine activity	CMTM3; IFNA13; IL36A; TXLNA; Ccl12; IL23; HMGB1; ILTIFB; IL32; CSF3
growth factor activity	CSF1B; FGF6A; AGT; INHBA; COL20A1; ENDOU; FGF13A; PSPN; NRTN; CXCL1
interleukin-3 receptor binding	RNF41; IL3

IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.

CSF2RB

Barr, TP; Kornberg, D; et al. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. ANALYTICAL BIOCHEMISTRY 468:28-33(2015).

Abrishami, M; Pastushok, L; et al. Synthetic Anti-IL3 Receptor Antibodies As Therapeutics to Block Innate Imatinib Resistance in Chronic Myelogenous Leukemia. BLOOD 124:-(2014).

IL3

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