What is the difference in clinical presentation of IL-3 compared to GM-CSF?29/12/2022
Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.
Since basophils are the target and source of IL-3, can they regulate the secretion of IL-3 to treat allergic diseases?05/11/2018
IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.
IL-3 specific receptor subunit CD123 is overexpressed in many hematological malignancies,Is it overexpressed in normal tissues where inflammation occurs?16/09/2018
non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.
Since the structure of IL-3 is different between animals and humans, does it mean that il-3 is not necessary to maintain stable hematopoietic function?14/03/2018
mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells
How does the structure of IL-3 in animals differ from that in humans?12/03/2018
Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.
Which hematopoietic and non-hematopoietic cell subsets express IL-3?21/12/2017
E.g., lymphocytes,epithelial cells, and fibroblasts
What is the difference between IL-3 and GM-CSF In vitro?11/11/2017
In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.
Does loss of cytokine IL-3 affect normal granulocyte, monocyte, and basophil levels?02/11/2017
Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate
hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.
When is IL-3 activated by T cells?01/06/2017
Such as allergic inflammation and parasitic infestation.
T cell IL-3 expression is specifically regulated by which transcription factor?05/01/2016
