|Official Full Name||interleukin 3|
|Background||The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.|
|Synonyms||Colony stimulating factor multiple; Hematopoietic growth factor; IL 3; IL-3; IL3; IL3_HUMAN; Interleukin 3 (colony stimulating factor, multiple); Interleukin 3; Interleukin-3; Mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; Multipotential colony stimulating factor; Multipotential colony-stimulating factor; OTTHUMP00000065963; P cell stimulating factor; P-cell-stimulating factor; BPA; PSF; HCGF; Csfmu; nterleukin-3; TTMUSP00000005831; ast cell growth factor|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||ACVR2AA; IL12B; OSTN; CCL15; CCR6A; PDGFB; OSMR; TSLP; GH1; IFNGR2|
|PIK-Akt signaling pathway||PHLPP2; ITGA2B; KLK1B4; PCK2; FGF10; IFNA8; GSK3B; TNC; LAMA4; ITGA8|
|Apoptosis||VIML; Fasl; TICAM1; PKP1; IL1B2; IRF2A; BAXA; PIK3R2; PIK3R3A; PRKAR2B|
|Jak-STAT signaling pathway||PIK3R3B; LIFRA; IFNA1; IFNB1; RAF1B; MTOR; IL28A; SOCS9; IL24; CSH1|
|Hematopoietic cell lineage||IL11RA2; EPO; CD1D2; CSF3; CD1E, B2M; CD34; IL9R; CR1; CD19; CD9|
|Fc epsilon RI signaling pathway||MAPK8; LAT; MAP2K3; PLA2G4A; FCER1A; RAC1; MAP2K4; PIK3R5; IL3; PLCG2|
|Transcriptional misregulation in cancer||SIX1; PBX3; TCF3; Pdgfa&Pdgfb; IL2RB; KLF3; BCL2L1; PML; CD14; SSX1|
|Asthma||IL10; EPX; IL5; HLA-DPB1; MS4A2; H2-AA; IL9; HLA-DRB1; PRG2; IL3|
IL3 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.
|cytokine activity||IL36RN; HMGB1A; IL17A/F3; VSTM1; INHBB; IL28A; IFNA1; Il2; SCG2; CMTM2|
|growth factor activity||OGN; LFT2; FGF3; EGF; FGF14; CECR1; GMFG; FGF11A; AGT; HBEGF|
|interleukin-3 receptor binding||IL3; RNF41|
IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.
Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.
IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.
non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.
mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells
Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.
E.g., lymphocytes,epithelial cells, and fibroblasts
In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.
Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.
Such as allergic inflammation and parasitic infestation.
Required fields are marked with *×
It was accurately quantified in expression analysis. -
Suitable for subcellular localization. -
Useful in immunohistochemical experiments -
Successfully used for drug target screening. -
Can effectively induce the differentiation and proliferation of myeloid cells in vitro. -
Required fields are marked with *×
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