IL3

  • Official Full Name

    interleukin 3

  • Overview

    The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
  • Synonyms

    Colony stimulating factor multiple; Hematopoietic growth factor; IL 3; IL-3; IL3; IL3_HUMAN; Interleukin 3 (colony stimulating factor, multiple); Interleukin 3; Interleukin-3; Mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; Multipotential colony stimulating factor; Multipotential colony-stimulating factor; OTTHUMP00000065963; P cell stimulating factor; P-cell-stimulating factor; BPA; PSF; HCGF; Csfmu; nterleukin-3; TTMUSP00000005831; ast cell growth factor;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Chicken
  • Cynomolgus
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293F
  • Hordeum Vulgare
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Nicotiana Benthamiana
  • S.cerevisiae
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • His|T7
  • HQ
  • Met
  • N/A
  • N
  • MBP
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL3-145H Active Recombinant Human IL3, His-tagged, Animal Free Nicotiana Benthamiana His
Human IL3-200H Active Recombinant Human IL3 CHO N/A
Human IL3-8862H Active Recombinant Human IL3, His-tagged Hordeum Vulgare N/A
Human CSF3&IL3-5H Active Recombinant Human GM-CSF/IL-3 (PIXY321) Fusion Protein E.coli N/A
Human IL3-120H Active Recombinant Human Interleukin 3 (Colony-stimulating Factor, Multiple) HEK293 N/A
Human IL3-503H Active Recombinant Human IL3 HEK293 N/A
Human IL3-436H Active Recombinant Human IL3 protein(Ala20-Phe152) E.coli N/A Ala20-Phe152
Human IL3-01HG Active GMP Recombinant Human IL3 Protein CHO-K1
Human IL3-075HG Active GMP Recombinant Human IL3 protein E.coli N/A
Human IL3-132H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), His-tagged Insect Cell His
Human IL3-275H Recombinant Human Interleukin 3 (Colony-Stimulating Factor, Multiple) S.cerevisiae N/A
Human IL3-88H Recombinant Human GMCSF/IL-3 Fusion Protein E.coli N/A
Human IL3-435H Active Recombinant Human IL3 protein(Met1-Phe152), His-tagged HEK293 C-His Met1-Phe152
Human IL3-08H Recombinant Human IL3 protein E.coli N/A 133
Human IL3-604H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged Hordeum Vulgare HQ
Human IL3-56H Recombinant Human IL3, His-tagged E.coli His
Human IL3-1556H Recombinant human IL3, Active, His-tagged Nicotiana Benthamiana His
Human IL3-378H Recombinant Human IL3, His tagged Insect Cell His
Human IL3-639H Recombinant Human IL3 protein, His & GST-tagged E.coli His/GST Ala20~Phe152
Human IL3-607HCL Recombinant Human IL3 cell lysate Insect Cell N/A
Human IL3-106H Human Interleukin-3 (rDNA derived) Reference standard N/A
Human IL3-3102H Recombinant Human IL3 protein, GST-tagged E.coli GST 20-152aa
Human IL3-097I Active Recombinant Human IL3 Protein (133 aa) E.coli 133
Human IL3-5192H Recombinant Human IL3 Protein, GST-tagged Wheat Germ GST
Human IL3-187H Recombinant Active Human IL3 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL3-5760HF Recombinant Full Length Human IL3 Protein, GST-tagged In Vitro Cell Free System GST 152 amino acids
Human IL3-358I Active Recombinant Human IL3 Protein (134 aa) E.coli 134
Human IL3-065H Active Recombinant Human IL3 Protein E.coli
Human IL3-131H Recombinant Human IL3 protein, His-Avi-tagged HEK293 His-Avi It contains Ala20-Phe152.
Human IL3-168H Active Recombinant Human IL3 Protein E.coli
Human IL3-077HG Active GMP Recombinant Human IL-3 protein HEK293 DNA sequence encoding Human IL-3 (GenBank: AAA59146.1) was expressed with His tag at the C-terminal.
Human IL3-35H Active Recombinant Human IL3 Protein, Animal Free Human cells
Human IL3-246I Active Recombinant Human IL3 Protein CHO
Human Il3-1922H Recombinant Human Il3 Protein Insect Cell N/A
Human IL3-07H Active Recombinant Human IL3 Protein, Pre-aliquoted E.coli Ala20-Phe152, with and without an N-terminal Met
Human IL3-1036H Recombinant Human IL3 Protein, His-tagged HEK293F N-His Ala20-Phe152
Human IL3-26HG Active Recombinant Human IL3 Protein (Ala20-Phe152), GMP Grade, Animal-Free E.coli Ala20-Phe152
Human IL3-4276H Recombinant Human IL3 Protein (Met1-Phe152), C-His tagged Mammalian cells C-His Met1-Phe152
Human IL3-248H Active Recombinant Human IL3 Protein E.coli Tag Free
Human IL3-4277H Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged Mammalian cells C-His Ala20-Phe152
Human IL3-32HG Recombinant Human IL3 Protein, GMP Grade, Animal-Free E.coli
Human IL3-2601H Recombinant Human IL3 protein(41-130 aa), N-MBP & C-His-tagged E.coli N-MBP & C-His 41-130 aa
Human IL3-2481H Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged E.coli C-His Ala20-Phe152
Human IL3-167H Active Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala20-Phe152
Human IL3-140H Recombinant Human IL3 Protein, Ala20-Phe152, N-His-Avi tagged, Biotinylated HEK293 N-His-Avi Ala20-Phe152
Human IL3-2600H Recombinant Human IL3 protein(41-130 aa), C-His-tagged E.coli C-His 41-130 aa
Human IL3-132HG GMP Recombinant Human IL3 protein E.coli N/A 133
Mouse Il3-592M Active Recombinant Mouse Interleukin 3 Mouse N/A
Mouse Il3-644M Active Recombinant Mouse Il3 E.coli Met Asp33-Cys166
Mouse Il3-01M Active Recombinant Mouse Il3 Protein, His-Tagged E.coli His
Mouse IL3-1169M Recombinant Mouse IL3 protein(Met1-Cys166) HEK293 N/A Met1-Cys166
Mouse IL3-455M Active Recombinant Mouse IL3 Protein HEK293 N/A Met1-Cys166
Mouse Il3-641M Recombinant Mouse Il3 protein, His & GST-tagged E.coli His/GST Asp33~Cys166 (Accession # P01586)
Mouse Il3-640M Recombinant Mouse Il3 protein, His & T7-tagged E.coli His/T7 Asp33~Cys166 (Accession # P01586)
Mouse ll3-542M Recombinant Mouse Iterleukin 3 Mouse N/A
Mouse Il3-366M Recombinant Mouse Il3 Protein, His-tagged Insect Cell His
Mouse Il3-09M Recombinant Mouse Il3 protein E.coli N/A 134
Mouse Il3-357I Active Recombinant Mouse Il3 Protein (135 aa) E.coli 135
Mouse Il3-114M Mouse Interleukin-3 (rDNA derived) Reference standard N/A
Mouse Il3-7242M Active Recombinant Mouse Il3 Protein, His-tagged Insect Cell His 27-166
Mouse Il3-58M Active Recombinant Mouse Il3 Protein (Asp33-Cys166), C-His tagged, Animal-free, Carrier-free E.coli C-His Asp33-Cys166
Mouse IL3-88M Recombinant Mouse IL3 Protein, His-tagged Human Cell His
Mouse Il3-107M Active Recombinant Mouse Il3 Protein E.coli
Mouse IL3-0221M Active Recombinant Mouse IL3 protein, His-tagged HEK293 His Ala27-Cys166
Mouse IL3-169M Active Recombinant Mouse IL3 Protein E.coli
Mouse Il3-108M Active Recombinant Mouse Il3 Protein E.coli
Mouse Il3-188M Recombinant Active Mouse IL3 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il3-027I Active Recombinant Mouse Il3 Protein (135 aa) E.coli 135
Rat IL3-1093R Active Recombinant Rat IL3 Protein, His-tagged Insect Cell His
Rat Il3-576R Recombinant Rat Il3 protein E.coli N/A 144
Rat Il3-642R Recombinant Rat Il3 protein, His & T7-tagged E.coli His/T7 Ile27~Cys166 (Accession # P04823)
Rat Il3-643R Recombinant Rat Il3 protein, His & GST-tagged E.coli His/GST Ile27~Cys166 (Accession # P04823)
Rat Il3-591R Recombinant Rat Interleukin 3 E.coli N/A
Rat IL3-445RCL Recombinant Rat IL3 cell lysate Insect Cell N/A
Rat Il3-247I Active Recombinant Rat Il3 Protein, His-tagged CHO His
Rat Il3-1037R Recombinant Rat Il3 Protein, His-tagged HEK293F N-His Ile27-Cys166
Rat IL3-170R Active Recombinant Rat IL-3β Protein E.coli
Rat Il3-355I Active Recombinant Rat Il3β Protein (144 aa) E.coli 144
Dog IL3-362D Recombinant Dog Interleukin 3 (colony-stimulating factor, multiple) E.coli N/A
Dog IL3-1035D Recombinant Dog IL3 Protein, His-tagged E.coli N-His Arg24-Pro143
Bovine IL3-4369B Recombinant Bovine IL3 Protein Yeast N/A 127aa
Canine IL3-407D Recombinant Canine IL3 protein E.coli N/A 120
Cynomolgus IL3-0220C Active Recombinant Cynomolgus IL3 protein, His-tagged HEK293 His Ala20-Gln143
Rhesus IL3-539R Recombinant Rhesus IL3 protein E.coli N/A 124
Rhesus Macaque IL3-2250R Recombinant Rhesus monkey IL3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL3-2071R Recombinant Rhesus Macaque IL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IL3-2071R-B Recombinant Rhesus Macaque IL3 Protein Pre-coupled Magnetic Beads HEK293
Chicken IL3-1734C Recombinant Chicken IL3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL3 Related Signal Pathway

IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL17A;IL6;CCL27;PDGFC;IFNPHI3;CCL24;GDF5;PRL2;RNF207B
PIK-Akt signaling pathwayIFNA1;ANGPT2;IL7R;PPP2R2A;ITGA1;LPAR3;FGF14;GNG4;EIF4E2
ApoptosisAKT2L;BCL2A;IRF2A;BIRC7;CASP12;CDK5RAP2;NFKB1;GAS2;BIRC5A
Jak-STAT signaling pathwayFHL1;GFAP;PRP2;IL11;MTOR;CTF1;EPO;IFNPHI3;IFNG
Hematopoietic cell lineageIL7R;FLT3;ITGA1;FLT3LG;IL11RA;IL6R;Cd24a;IL9R;GP9
Fc epsilon RI signaling pathwayMAPK1;MAP2K4;NRAS;MAPK8;VAV1;AKT2;RAF1;PIK3CA;RAC2
Transcriptional misregulation in cancerCCNT2;TCF3;PAX3;IL-8;HIST2H3A;DDX5;ARNT2;REL;MEIS1
AsthmaCCL11;TNF;EPX;HLA-DRB3;HLA-DPA1;H2-AB1;IL3;PRG2;MS4A2

IL3 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL17C;IL17B;IL17A/F1;BMP7A;CER1;LEFTY2;BMP10;OSM;IFNA16
growth factor activityPdgfa&Pdgfb;GPR19;CECR1;PROK1;IL9;OSM;NTF4;TGFB2;IL3
interleukin-3 receptor bindingRNF41;IL3

IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.

CSF2RB

Gene Family

IL Cytokines

Research Area

Related articles

Barr, TP; Kornberg, D; et al. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. ANALYTICAL BIOCHEMISTRY 468:28-33(2015).
Abrishami, M; Pastushok, L; et al. Synthetic Anti-IL3 Receptor Antibodies As Therapeutics to Block Innate Imatinib Resistance in Chronic Myelogenous Leukemia. BLOOD 124:-(2014).
  • Q&As
  • Reviews

Q&As (16)

Ask a question
What is the difference between IL-3 and GM-CSF In vitro? 04/14/2023

In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.

What is the difference in clinical presentation of IL-3 compared to GM-CSF? 04/14/2023

Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.

Since the structure of IL-3 is different between animals and humans, does it mean that il-3 is not necessary to maintain stable hematopoietic function? 04/14/2023

mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells

How does the structure of IL-3 in animals differ from that in humans? 04/14/2023

Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.

Does loss of cytokine IL-3 affect normal granulocyte, monocyte, and basophil levels? 04/14/2023

Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.

IL-3 specific receptor subunit CD123 is overexpressed in many hematological malignancies,Is it overexpressed in normal tissues where inflammation occurs? 04/14/2023

non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.

When is IL-3 activated by T cells? 04/14/2023

Such as allergic inflammation and parasitic infestation.

Since basophils are the target and source of IL-3, can they regulate the secretion of IL-3 to treat allergic diseases? 04/14/2023

IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.

T cell IL-3 expression is specifically regulated by which transcription factor? 04/14/2023

Bhlhe40

Which hematopoietic and non-hematopoietic cell subsets express IL-3? 04/14/2023

E.g., lymphocytes,epithelial cells, and fibroblasts

Are there any completed clinical trials on IL3? 12/20/2021

Yes, there are some completed clinical trials on IL3 results, but the specific results need to refer to the relevant research papers.

What is the effect of IL3 on hematopoietic system? 09/29/2021

This protein can promote stem cell proliferation and differentiation during hematopoietic process, thus increasing the production of different types of blood cells.

Are there any side effects of IL3? 09/24/2019

In general, the IL3 has relatively few side effects, but some unpleasant symptoms such as fever, headache and nausea may occur.

IL3 associated with whether the immune adjustment? 06/28/2019

IL3 can regulate the body's immune response and the function of immune cells, and plays an important role in immune regulation.

What is the solubility and stability of IL3? 05/25/2019

IL3 generally have good solubility and stability, making them easier to handle during drug preparation and storage.

How is the research progress of IL3? 02/27/2019

The study of IL3 is ongoing, including its application in the development of therapeutic drugs, as well as in combination therapy with other immune molecules.

Customer Reviews (3)

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06/20/2022

    I've used many brands, but this one is one of my favorites.

    03/08/2021

      The performance is very stable and the price is very reasonable. I would definitely buy this product again.

      12/19/2020

        I have recommended this brand to my colleagues and friends, and they all praise this product.

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