IL3 Protein

IL3

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IL3

Official Full Name interleukin 3
Background The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Synonyms Colony stimulating factor multiple; Hematopoietic growth factor; IL 3; IL-3; IL3; IL3_HUMAN; Interleukin 3 (colony stimulating factor, multiple); Interleukin 3; Interleukin-3; Mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; Multipotential colony stimulating factor; Multipotential colony-stimulating factor; OTTHUMP00000065963; P cell stimulating factor; P-cell-stimulating factor; BPA; PSF; HCGF; Csfmu; nterleukin-3; TTMUSP00000005831; ast cell growth factor
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • CHO-K1
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • Hordeum Vulgare
    • Human Cell
    • Human cells
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Nicotiana Benthamiana
    • S.cerevisiae
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • His(C-ter)
    • T7
    • His-Avi
    • HQ
    • Met
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CSF3&IL3-5H Active Recombinant Human GM-CSF/IL-3 (PIXY321) Fusion Protein E.coli N/A Inquiry
    Human IL3-120H Active Recombinant Human Interleukin 3 (Colony-stimulating Factor, Multiple) HEK293 N/A Inquiry
    Human IL3-145H Active Recombinant Human IL3 Active, His-tagged, Animal Free Nicotiana Benthamiana His Inquiry
    Human IL3-200H Active Recombinant Human IL3 CHO N/A Inquiry
    Human IL3-436H Active Recombinant Human IL3 Protein E.coli N/A Inquiry
    Human IL3-503H Active Recombinant Human IL3 HEK293 N/A Inquiry
    Human IL3-8862H Active Recombinant Human IL3, His-tagged Hordeum Vulgare N/A Inquiry
    Mouse Il3-592M Active Recombinant Mouse Interleukin 3 Mouse N/A Inquiry
    Mouse Il3-644M Active Recombinant Mouse Il3 E.coli Met Inquiry
    Rat IL3-1093R Active Recombinant Rat IL3 Protein, His-tagged Insect Cell His Inquiry
    Human IL3-01HG Active GMP Recombinant Human IL3 Protein CHO-K1 Inquiry
    Mouse Il3-01M Active Recombinant Mouse Il3 Protein, His-Tagged E.coli His Inquiry
    Human IL3-075HG Active GMP Recombinant Human IL3 protein E.coli N/A Inquiry
    Human IL3-08H Recombinant Human IL3 protein E.coli N/A Inquiry
    Human IL3-132H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), His-tagged Insect Cell His Inquiry
    Human IL3-1556H Recombinant human IL3, Active, His-tagged Nicotiana Benthamiana His Inquiry
    Human IL3-275H Recombinant Human Interleukin 3 (Colony-Stimulating Factor, Multiple) S.cerevisiae N/A Inquiry
    Human IL3-378H Recombinant Human IL3, His tagged Insect Cell His Inquiry
    Human IL3-435H Recombinant Human IL3 Protein, His-tagged HEK293 His Inquiry
    Human IL3-56H Recombinant Human IL3, His-tagged E.coli His Inquiry
    Human IL3-604H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged Hordeum Vulgare HQ Inquiry
    Human IL3-639H Recombinant Human IL3 protein, His & GST-tagged E.coli His/GST Inquiry
    Human IL3-88H Recombinant Human GMCSF/IL-3 Fusion Protein E.coli N/A Inquiry
    Mouse Il3-09M Recombinant Mouse Il3 protein E.coli N/A Inquiry
    Mouse Il3-366M Recombinant Mouse Il3 Protein, His-tagged Insect Cell His Inquiry
    Mouse Il3-640M Recombinant Mouse Il3 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Il3-641M Recombinant Mouse Il3 protein, His & GST-tagged E.coli His/GST Inquiry
    Mouse ll3-542M Recombinant Mouse Iterleukin 3 Mouse N/A Inquiry
    Rat Il3-576R Recombinant Rat Il3 protein E.coli N/A Inquiry
    Rat Il3-591R Recombinant Rat Interleukin 3 E.coli N/A Inquiry
    Rat Il3-642R Recombinant Rat Il3 protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Il3-643R Recombinant Rat Il3 protein, His & GST-tagged E.coli His/GST Inquiry
    Rhesus Macaque IL3-2250R Recombinant Rhesus monkey IL3 Protein, His-tagged Mammalian Cell His Inquiry
    Rhesus IL3-539R Recombinant Rhesus IL3 protein E.coli N/A Inquiry
    Dog IL3-362D Recombinant Dog Interleukin 3 (colony-stimulating factor, multiple) E.coli N/A Inquiry
    Canine IL3-407D Recombinant Canine IL3 protein E.coli N/A Inquiry
    Chicken IL3-1734C Recombinant Chicken IL3 Mammalian Cell His Inquiry
    Human IL3-607HCL Recombinant Human IL3 cell lysate Insect Cell N/A Inquiry
    Rat IL3-445RCL Recombinant Rat IL3 cell lysate Insect Cell N/A Inquiry
    Mouse Il3-027I Recombinant Mouse Il3 Protein (135 aa) E.coli Inquiry
    Human IL3-065H Recombinant Human IL3 Protein E. coli Inquiry
    Human IL3-07H Recombinant Human IL3 Protein, Pre-aliquoted E.coli Inquiry
    Human IL3-097I Recombinant Human IL3 Protein (133 aa) E.coli Inquiry
    Dog IL3-1035D Recombinant Dog IL3 Protein, His-tagged E.coli N-His Inquiry
    Human IL3-1036H Recombinant Human IL3 Protein, His-tagged HEK293F N-His Inquiry
    Rat Il3-1037R Recombinant Rat Il3 Protein, His-tagged HEK293F N-His Inquiry
    Human IL3-168H Recombinant Human IL3 Protein E.coli Inquiry
    Mouse IL3-169M Recombinant Mouse IL3 Protein E.coli Inquiry
    Rat IL3-170R Recombinant Rat IL-3β Protein E.coli Inquiry
    Human IL3-187H Recombinant Active Human IL3 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Il3-188M Recombinant Active Mouse IL3 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL3-246I Recombinant Human IL3 Protein CHO Inquiry
    Rat Il3-247I Recombinant Rat Il3 Protein, His-tagged CHO His Inquiry
    Human IL3-26HG Recombinant Human IL3 Protein (Ala20-Phe152), GMP Grade, Animal-Free E.coli Inquiry
    Human IL3-3102H Recombinant Human IL3 protein, GST-tagged E.coli GST Inquiry
    Rat Il3-355I Recombinant Rat Il3β Protein (144 aa) E.coli Inquiry
    Mouse Il3-357I Recombinant Mouse Il3 Protein (135 aa) E.coli Inquiry
    Human IL3-358I Recombinant Human IL3 Protein (134 aa) E.coli Inquiry
    Human IL3-35H Recombinant Human IL3 Protein, Animal Free Human cells Inquiry
    Human IL3-5760HF Recombinant Full Length Human IL3 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Mouse IL3-88M Recombinant Mouse IL3 Protein, His-tagged Human Cell His Inquiry
    Human IL3-077HG GMP Recombinant Human IL-3 protein, His-tagged HEK293 His Inquiry
    Human IL3-106H Human Interleukin-3 (rDNA derived) Reference standard N/A Inquiry
    Human IL3-131H Recombinant Human IL3 protein, His-Avi-tagged HEK293 His-Avi Inquiry
    Human IL3-132HG GMP Recombinant Human IL3 protein E.coli N/A Inquiry
    Human Il3-1922H Recombinant Human Il3 Protein Insect Cell N/A Inquiry
    Human IL3-5192H Recombinant Human IL3 Protein, GST-tagged Wheat Germ GST Inquiry
    Mouse Il3-107M Recombinant Mouse Il3 Protein E.coli Inquiry
    Mouse Il3-108M Recombinant Mouse Il3 Protein E.coli Inquiry
    Mouse Il3-114M Mouse Interleukin-3 (rDNA derived) Reference standard N/A Inquiry
    Mouse IL3-455M Recombinant Mouse IL3 Protein HEK293 N/A Inquiry
    Mouse Il3-7242M Recombinant Mouse Il3 Protein, His-tagged Insect Cell His Inquiry
    Bovine IL3-4369B Recombinant Bovine IL3 Protein Yeast N/A Inquiry

    IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction ACVR2AA; IL12B; OSTN; CCL15; CCR6A; PDGFB; OSMR; TSLP; GH1; IFNGR2
    PIK-Akt signaling pathway PHLPP2; ITGA2B; KLK1B4; PCK2; FGF10; IFNA8; GSK3B; TNC; LAMA4; ITGA8
    Apoptosis VIML; Fasl; TICAM1; PKP1; IL1B2; IRF2A; BAXA; PIK3R2; PIK3R3A; PRKAR2B
    Jak-STAT signaling pathway PIK3R3B; LIFRA; IFNA1; IFNB1; RAF1B; MTOR; IL28A; SOCS9; IL24; CSH1
    Hematopoietic cell lineage IL11RA2; EPO; CD1D2; CSF3; CD1E, B2M; CD34; IL9R; CR1; CD19; CD9
    Fc epsilon RI signaling pathway MAPK8; LAT; MAP2K3; PLA2G4A; FCER1A; RAC1; MAP2K4; PIK3R5; IL3; PLCG2
    Transcriptional misregulation in cancer SIX1; PBX3; TCF3; Pdgfa&Pdgfb; IL2RB; KLF3; BCL2L1; PML; CD14; SSX1
    Asthma IL10; EPX; IL5; HLA-DPB1; MS4A2; H2-AA; IL9; HLA-DRB1; PRG2; IL3

    IL3 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IL36RN; HMGB1A; IL17A/F3; VSTM1; INHBB; IL28A; IFNA1; Il2; SCG2; CMTM2
    growth factor activity OGN; LFT2; FGF3; EGF; FGF14; CECR1; GMFG; FGF11A; AGT; HBEGF
    interleukin-3 receptor binding IL3; RNF41

    IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.

    CSF2RB

    Barr, TP; Kornberg, D; et al. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. ANALYTICAL BIOCHEMISTRY 468:28-33(2015).
    Abrishami, M; Pastushok, L; et al. Synthetic Anti-IL3 Receptor Antibodies As Therapeutics to Block Innate Imatinib Resistance in Chronic Myelogenous Leukemia. BLOOD 124:-(2014).

    Q&As (10)
    What is the difference in clinical presentation of IL-3 compared to GM-CSF?29/12/2022

    Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.

    Since basophils are the target and source of IL-3, can they regulate the secretion of IL-3 to treat allergic diseases?05/11/2018

    IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.

    IL-3 specific receptor subunit CD123 is overexpressed in many hematological malignancies,Is it overexpressed in normal tissues where inflammation occurs?16/09/2018

    non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.

    Since the structure of IL-3 is different between animals and humans, does it mean that il-3 is not necessary to maintain stable hematopoietic function?14/03/2018

    mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells

    How does the structure of IL-3 in animals differ from that in humans?12/03/2018

    Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.

    Which hematopoietic and non-hematopoietic cell subsets express IL-3?21/12/2017

    E.g., lymphocytes,epithelial cells, and fibroblasts

    What is the difference between IL-3 and GM-CSF In vitro?11/11/2017

    In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.

    Does loss of cytokine IL-3 affect normal granulocyte, monocyte, and basophil levels?02/11/2017

    Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.

    When is IL-3 activated by T cells?01/06/2017

    Such as allergic inflammation and parasitic infestation.

    T cell IL-3 expression is specifically regulated by which transcription factor?05/01/2016

    Bhlhe40

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