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What is the difference between IL-3 and GM-CSF In vitro?
In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.
What is the difference in clinical presentation of IL-3 compared to GM-CSF?
Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.
Since the structure of IL-3 is different between animals and humans, does it mean that il-3 is not necessary to maintain stable hematopoietic function?
mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells
How does the structure of IL-3 in animals differ from that in humans?
Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.
Does loss of cytokine IL-3 affect normal granulocyte, monocyte, and basophil levels?
Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate
hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.
IL-3 specific receptor subunit CD123 is overexpressed in many hematological malignancies,Is it overexpressed in normal tissues where inflammation occurs?
non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.
When is IL-3 activated by T cells?
Such as allergic inflammation and parasitic infestation.
Since basophils are the target and source of IL-3, can they regulate the secretion of IL-3 to treat allergic diseases?
IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.
T cell IL-3 expression is specifically regulated by which transcription factor?
Which hematopoietic and non-hematopoietic cell subsets express IL-3?
E.g., lymphocytes,epithelial cells, and fibroblasts
Are there any completed clinical trials on IL3?
Yes, there are some completed clinical trials on IL3 results, but the specific results need to refer to the relevant research papers.
What is the effect of IL3 on hematopoietic system?
This protein can promote stem cell proliferation and differentiation during hematopoietic process, thus increasing the production of different types of blood cells.
Are there any side effects of IL3?
In general, the IL3 has relatively few side effects, but some unpleasant symptoms such as fever, headache and nausea may occur.
IL3 associated with whether the immune adjustment?
IL3 can regulate the body's immune response and the function of immune cells, and plays an important role in immune regulation.
What is the solubility and stability of IL3?
IL3 generally have good solubility and stability, making them easier to handle during drug preparation and storage.
How is the research progress of IL3?
The study of IL3 is ongoing, including its application in the development of therapeutic drugs, as well as in combination therapy with other immune molecules.