Recombinant Human GNAQ Protein, GST-tagged

• Cat.No.: GNAQ-5046H
• Product Overview: Human GNAQ full-length ORF ( AAH57777, 1 a.a. - 359 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 65.23 kDa
• AA Sequence: MTLESIMACCLSEEAKEARRINDEI ERQLRRDKRDARRELKLLLLGTGES GKSTFIKQMRIIHGSGYSDEDKRGF TKLVYQNIFTAMQAMIRAMDTLKIP YKYEHNKAHAQLVREVDVEKVSAFE NPYVDAIKSLWNDPGIQECYDRRRE YQLSDSTKYYLNDLDRVADPAYLPT QQDVLRVRVPTTGIIEYPFDLQSVI FRMVDVGGQRSERRKWIHCFENVTS IMFLVALSEYDQVLVESDNENRMEE SKALFRTIITYPWFQNSSVILFLNK KDLLEEKIMYSHLVDYFPEYDGPQR DAQAAREFILKMFVDLNPDSDKIIY SHFTCATDTENIRFVFAAVKDTILQ LNLKEYNLV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GNAQ guanine nucleotide binding protein (G protein), q polypeptide [ Homo sapiens ]
• Official Symbol: GNAQ
• Synonyms: GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide-binding protein G(q) subunit alpha; G ALPHA q; GAQ; guanine nucleotide-binding protein alpha-q; G-ALPHA-q
• Gene ID: 2776
• mRNA Refseq: NM_002072
• Protein Refseq: NP_002063
• MIM: 600998
• UniProt ID: P50148