| Species : |
Human |
| Source : |
E.coli |
| Tag : |
His |
| Protein Length : |
2-558 |
| Description : |
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. |
| Molecular Mass : |
66.0 kDa |
| Purity : |
≥95% estimated by SDS-PAGE |
| Unit Definition : |
One unit is defined as the amount of enzyme required to reduce 1 µmol of NADP + to NADPH per minute at 25 centigrade in 50 mM Triethanolamine, pH 7.6, containing 1 mM MgCl2. |
| Stability : |
≥ 2 years |
| Storage : |
-80 centigrade |
| Storage Buffer : |
25 mM Tris-HCl, pH 7.0, 100 mM sodium chloride, and 10% glycerol |
| Shipping : |
Dry ice in continental US, may vary elsewhere. |
