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Recombinant Human HLA-B Protein, GST-tagged

Cat.No. : HLA-B-4833H
Product Overview : Human HLA-B full-length ORF (AAH13187.1, 1 a.a. - 362 a.a.) recombinant protein with GST tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq
Source : wheat germ
Species : Human
Tag : GST
Molecular Mass : 66.9 kDa
AA Sequence : MRVTAPRTVLLLLSGALALTETWAG SHSMRYFYTAMSRPGRGEPRFISVG YVDDTQFVRFDSDAASPREEPRAPW IEQEGPEYWDRNTQICKTNTQTYRE SLRNLRGYYNQSEAGSHTLQRMYGC DVGPDGRLLRGHDQYAYDGKDYIAL NEDLSSWTAADTAAQITQRKWEAAR EAEQLRAYLEGLCVEWLRRYLENGK ETLQRADPPKTHVTHHPISDHEATL RCWALGFYPAEITLTWQRDGEDQTQ DTELVETRPAGDRTFQKWAAVVVPS GEEQRYTCHVQHEGLPKPLTLRWEP SSQSTIPIVGIVAGLAVLAVVVIGA VVATVMCRRKSSGGKGGSYSQAASS DSAQGSDVSLTA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HLA-B major histocompatibility complex, class I, B [ Homo sapiens ]
Official Symbol : HLA-B
Synonyms : HLA-B; major histocompatibility complex, class I, B; ankylosing spondylitis , AS; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen HLA-B heavy chain; HLA class I histocompatibility antigen, B alpha chain; AS; HLAB; SPDA1; MGC111087;
Gene ID : 3106
mRNA Refseq : NM_005514
Protein Refseq : NP_005505
UniProt ID : P01889

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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