Recombinant Human HLA-DRA Protein (Lys27-Glu216), His tagged

• Cat.No.: HLA-DRA-3571H
• Product Overview: Recombinant human HLA-DRA (Lys27-Glu216) protein fused with His tag was expressed in E. coli.

Specification

• Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 23.23 kDa
• Protein Length: Lys27-Glu216
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: HLA-DRA major histocompatibility complex, class II, DR alpha [ Homo sapiens (human) ]
• Official Symbol: HLA-DRA
• Synonyms: HLA-DRA; major histocompatibility complex, class II, DR alpha; HLA DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; MLRW; HLA-DRA1; FLJ51114
• Gene ID: 3122
• mRNA Refseq: NM_019111
• Protein Refseq: NP_061984
• MIM: 142860
• UniProt ID: P01903