Recombinant Human IGF1R Protein, DDK-tagged

Cat.No. : IGF1R-1391H
Product Overview : Recombinant human IGF1R protein, fused to DDK tag at C-terminus, was expressed in Insect cell.
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Description : This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
Source : Insect cells
Species : Human
Tag : DDK
Form : 50 mM Tris.HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Molecular Mass : 22.2 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
Official Symbol : IGF1R
Synonyms : CD221; IGFIR; IGFR; JTK13
Gene ID : 3480
mRNA Refseq : NM_000875
Protein Refseq : NP_000866
MIM : 147370
UniProt ID : P08069

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which cellular compartments is IGF1R predominantly localized? 04/06/2022

IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival? 04/27/2021

Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation? 04/09/2020

IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling? 09/06/2019

There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R? 09/24/2018

Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling? 10/03/2016

Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation? 02/11/2016

IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.

Customer Reviews (3)

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Reviews
07/08/2022

    The product's exceptional purity facilitated precise quantification, ensuring data consistency.

    06/14/2019

      The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

      04/29/2018

        The product's consistent performance bolstered the dependability of our research conclusions.

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