igf1r

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igf1r

Official Full Name insulin-like growth factor 1 receptor
Background This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Synonyms IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
    • Species :
    • Chicken
    • Cynomolgus
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • His
    • Flag
    • GST
    • T7
    • His-Avi
    • Myc/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11558MH Mouse Anti-Human Insulin-like Growth Factor 1 Receptor Monoclonal Antibody Mouse N/A
    Human IGF1R-134H Recombinant Human IGF1R protein, DDK-tagged Insect Cell DDK
    Human IGF1R-1391H Recombinant Human IGF1R Protein, DDK-tagged Insect Cell DDK
    Human IGF1R-1392H Recombinant Human IGF1R Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IGF1R-1631H Recombinant Human Insulin-Like Growth Factor 1 Receptor Mammalian cells N/A
    Human IGF1R-169H Recombinant Human IGF1R protein, His-Avi-tagged HEK293 His-Avi
    Human IGF1R-1769H Recombinant Human IGF1R protein, His & T7-tagged E.coli His/T7
    Human IGF1R-180H Recombinant Human IGF1R protein, His-tagged HEK293 His
    Human IGF1R-214H Recombinant Human IGF1R protein, DDK/His-tagged HEK293 DDK/His
    Human IGF1R-2654H Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His S.frugiperda His/GST
    Human IGF1R-29114TH Recombinant Human IGF1R E.coli N/A
    Human IGF1R-29115TH Recombinant Human IGF1R, His-tagged His
    Human IGF1R-29118TH Recombinant Human IGF1R N/A
    Human IGF1R-2928HCL Recombinant Human IGF1R cell lysate Human Cell N/A
    Human IGF1R-3148H Recombinant Human IGF1R, His tagged Human Cell His
    Human IGF1R-330H Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged, Active Sf9 Insect Cell GST
    Human IGF1R-50H Recombinant Human IGF1R, His & GST tagged Insect Cell His/GST
    Human IGF1R-51H Recombinant Human IGF1R protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human IGF1R-595H Recombinant Human IGF1R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IGF1R-663H Recombinant Human Insulin-Like Growth Factor 1 Receptor Human N/A
    Mouse Igf1r-1223M Recombinant Mouse Igf1r Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IGF1R-22M Recombinant Mouse IGF1R Protein, His-tagged CHO His
    Mouse IGF1R-392M Recombinant Mouse IGF1R protein, His-tagged HEK293 His
    Rat IGF1R-3004R Recombinant Rat IGF1R Protein Mammalian Cell His
    Rat Igf1r-30R Recombinant Rat Igf1r protein, His-tagged E.coli His
    Rat IGF1R-393R Recombinant Rat IGF1R protein, His-tagged HEK293 His
    Cynomolgus IGF1R-391H Recombinant Cynomolgus IGF1R protein, His-tagged HEK293 His
    Rhesus Macaque IGF1R-2216R Recombinant Rhesus monkey IGF1R Protein, His-tagged Mammalian Cell His
    Chicken IGF1R-6589C Recombinant Chicken IGF1R Mammalian Cell His
    Kit-1600 IGF1R Functional Assay Kit N/A
    Kit-1601 HEK 293 IGF1R Bioassay Kit N/A

    igf1r involved in several pathways and played different roles in them. We selected most pathways igf1r participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf1r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PRKCA; GNGT2; GRIN2A; SHOC2; PAK7; PIK3R2; PLA2G4F; ANGPT1; PLA2G1B; MAP2K1
    Rap signaling pathway ITGAL; ANGPT4; MAPK13; FPR1; RAC1; PRKCA; MAP2K1; NRAS; BCAR1; PFN1
    HIF- signaling pathway PDHB; PLCG1; PDK1; EPO; ENO1; IL6R; IL6; PIK3CG; PIK3CD; ARNT
    FoxO signaling pathway AKT2; PIK3CA; CDKN1BA; BNIP3; PLK2B; PIK3R2; RAG1; NRAS; SGK3; RAG2
    Oocyte meiosis PRKACBA; INS2; PTTG2; CTH1; PPP3CCA; ANAPC1; RPS6KA3A; PPP3R2; CALM3A; PPP1CAB
    Endocytosis RHOAB; FOLR2; SRC; AMPH; LDLRAP1B; PIP5K1A; RHOA; PIP5K1C; RAB31; VPS26B
    PIK-Akt signaling pathway ANGPT2; PGF; FGF9; MTOR; TLR4; IFNAR1; RAC1; NR4A1; PPP2R5A; CCNE1
    AMPK signaling pathway AKT1; RAB10; Scd2; RAB2A; CREB3L4; PPARG; PPP2R5C; PPP2CB; HMGCR; CPT1A
    Focal adhesion RAC1A; RAC3A; AKT3A; ITGA1; PDGFAA; IGF1RA; FYNB; THBS2; ITGA8; PTENA
    Adherens junction PVRL3; MAPK1; PTBP3; ACTN3B; SSX2IP; PTPRJ; VCLA; IGF1RA; RAC3B; CTNNA1
    Signaling pathways regulating pluripotency of stem cells WNT11; FZD6; LEFTY2; AXIN1; FZD5; MAPK3; PIK3R1; ACVR2B; MEIS1; WNT6
    Long-term depression BRAF; IGF1R; GNA11; GRM1; ITPR1; GNAS; PPP2CB; KRAS; GNA13; PLCB3
    Ovarian steroidogenesis LHB; HSD3B1; HSD3B5; Adcy4; PLA2G4D; LDLR; ALOX5; FSHR; BMP6; STAR
    Progesterone-mediated oocyte maturation MAPK8A; IGF1RB; GNAIA; ADCY2B; GNAI2; HSP90AA1.1; RPS6KA3; PIK3CG; IGF1R; PRKACBB
    Pathways in cancer KIT; HDAC1; ROCK2; FZD10; MAP2K1; KITLG; ABL1; Fzd4; MMP1A; NCOA4
    Transcriptional misregulation in cancer MEF2C; SIN3A; ETV7; HIST1H3F; MET; SIX4; MEIS1; HIST1H3G; MAF; IL1R2
    Proteoglycans in cancer WNT3; CBLB; IGF1; CAV3; CBLC; WNT2B; IL12B; ARAF; IGF2; HGF
    Glioma CAMK2A; CAMK2D; PIK3R3; GRB2; NRAS; PDGFB; HRAS; CALM1; RAF1; PTEN
    Prostate cancer PIK3CB; SOS1; TRP53; MAP2K2; LEF1; INS1; ACTL6B; PIK3CA; NKX3-1; HSP90B1
    Melanoma PIK3CD; FGF14; IGF1R; MAP2K2; FGF20; FGF6; FGF1; MAPK1; MET; FGF12

    igf1r has several biochemical functions, for example, ATP binding, G-protein alpha-subunit binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf1r itself. We selected most functions igf1r had, and list some proteins which have the same functions with igf1r. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DHX30; UBE2QL1; PGK1; TOR1L1; MAPKAPK2; ABCG2A; MYO9B; GATC; cka1; PIK3C2B
    G-protein alpha-subunit binding LPAR1; AGTR1A; DRD1A; RIC8A; F2RL1; NUCB1; RIC8; ARHGEF11; HTR2B; OPRM1
    identical protein binding TNPO3; ATG101; SHARPIN; ESYT2; PPP5C; PRMT8; TLE1; MCPH1; AMELX; EPHA4
    insulin binding INSR; IDE; PIK3R1; HSPD1; IGF1R; C2CD2L
    insulin receptor binding DOK7; DOK1; INS1; DOK5; FRS2A; PTPN1; INS2; SNX1; SNX4; SHC1
    insulin receptor substrate binding PRKCZ; IGF1RA; JAK2; PRKCD; IGF1R; PIK3CB; INSR; PTPN11; INSRR; PIK3CA
    insulin-like growth factor I binding IGF1R; IGFBP1B; IGFBP5B; IGFBP2; IGFBP6; IGFBP6B; IGFBP4; IGFBP5; IGFBP5A; IGFBP2A
    insulin-like growth factor binding HTRA1A; IGF1RB; Igfbpl1; CTGFB; IGFBP6B; IGF2R; HTRA1; CTGF; IGFBP1B; NOV
    insulin-like growth factor-activated receptor activity IGF2R; IGF1R
    phosphatidylinositol 3-kinase binding INSRR; INSR; FYN; INSRB; CALM1; JAK2; FLT3; HCST; IRS4; TYRO3
    protein binding UBXN6; RTN1; TAF1A; ITPRIPL1; DTX3L; LIMS3L; HDHD3; ATP2B4; WBSCR27; BSX
    protein tyrosine kinase activity JAK2; MUSK; INSRA; JAK2B; EPHA4A; EPHB4A; KDRL; DSTYK; FGR; TTN

    igf1r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf1r here. Most of them are supplied by our site. Hope this information will be useful for your research of igf1r.

    YWHAB; PIK3R1; PTPN1; ARHGEF12

    Huang, CT; Chang, MC; et al. Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. CANCER LETTERS 359:117-126(2015).
    Wang, YX; Zhu, LY; et al. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17 beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1382-E1391(2015).

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