IGF1R
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Official Full Name
insulin-like growth factor 1 receptor
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Overview
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] -
Synonyms
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor;
- Recombinant Proteins
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- His
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- Non
- Involved Pathway
- Protein Function
- Interacting Protein
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IGF1R involved in several pathways and played different roles in them. We selected most pathways IGF1R participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | HRAS;RHOA;MAPK10;GNB3;RASSF1;MAP2K2;VEGFC;PDGFC;PLA2G6 |
Rap signaling pathway | ITGB2;CDH1;FGF12;FGF18;NGF;ITGB1;TLN1;ANGPT2;FARP2 |
HIF- signaling pathway | PDK1;PIK3R1;NPPA;ANGPT2;MAPK1;RELA;ANGPT4;PLCG2;CAMK2D |
FoxO signaling pathway | AKT3A;PIK3CB;TGFBR1B;SMAD4;TGFB2;PRKAB1A;IL7R;GADD45B;SMAD2 |
Oocyte meiosis | PPP2CB;CALM2;PPP1CB;ANAPC4;SGOL1;REC8;PRKACA;PRKACB;CDK1 |
Endocytosis | PIP5K1C;VTA1;VPS35;SRC;KDR;SH3GL2;HSC70;SH3GL1;RAB11FIP4B |
PIK-Akt signaling pathway | MET;COL4A1;FGF11;PDGFD;PKN3;PHLPP1;IFNA14;Il6ra;IL2RA |
AMPK signaling pathway | SIRT1;PFKFB1;PPP2R5D;PPP2R3C;FOXO1;CREB3L1;RPS6KB1;PPP2CB;STRADA |
Focal adhesion | FLNC;TNR;PIK3R2;THBS4B;CAPN2L;PAK7;PDGFRA;ROCK2B;ERBB2 |
Adherens junction | LMO7A;WASF1;CTNND1;TGFBR1B;CSNK2A2;IGF1RB;CREBBP;VCL;WASF3B |
Signaling pathways regulating pluripotency of stem cells | PCGF6;APC;SOX2;WNT7A;WNT5A;BMPR1A;SMAD1;BMPR2;FGFR1 |
Long-term depression | ARAF;PLA2G4F;GNAO1;GNAZ;NOS1;PLCB1;PLA2G4C;KRAS;HRAS |
Ovarian steroidogenesis | PLA2G4D;CYP2J6;PTGS2;IGF1;FSHB;LDLR;FSHR;CYP2J5;SCARB1 |
Progesterone-mediated oocyte maturation | PRKACAB;RPS6KA6;ANAPC11;HSP90AA1.1;INSB;MAD1L1;AKT2L;CDC26;ANAPC13 |
Pathways in cancer | PTCH2;BIRC8;FGF18;WNT3A;LPAR6;MSH3;SFPI1;LAMB3;SMAD3 |
Transcriptional misregulation in cancer | HIST1H3D;MLL1;IL-8;MEIS1;SPI1;MYCN;GOLPH3;Aff1;PER2 |
Proteoglycans in cancer | FZD9;CCND1;FLNC;PPP1R12C;SDC4;PLCG1;CTTN;PIK3CB;CAV1 |
Glioma | PIK3R2;KRAS;SHC2;PRKCB;CALML5;CAMK2A;PDGFA;SHC1;IGF1 |
Prostate cancer | CASP9;INS1;TGFA;PIK3CG;IGF1R;FOXA1;NKX3;SPRY1;PIK3R3 |
Melanoma | PDGFRB;FGF22;RAF1;MAPK1;FGF7;PDGFA;FGF18;CCND1;IGF1R |
IGF1R has several biochemical functions, for example, ATP binding, G-protein alpha-subunit binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1R itself. We selected most functions IGF1R had, and list some proteins which have the same functions with IGF1R. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ATP6V1AA;MATK;CAMK1D;ERCC6;CSNK1D;TLK1B;NADSYN1;RPS6KB1B;ALPK1 |
G-protein alpha-subunit binding | IGF1R;F2R;RGS4;PPP5C;RGS14;DRD1A;LPAR1;ADRB2;HTR2B |
identical protein binding | DYNLRB1;KHDRBS1;NOD1;SLK;APOH;SIAH1A;PFKL;THBS1;S100B |
insulin binding | IDE;C2CD2L;PIK3R1;HSPD1;IGF1R;INSR |
insulin receptor binding | INSL3;ENPP1;INS1;PIK3R1;INS2;PTPN11;DOK1B;DOK2;IRS2 |
insulin receptor substrate binding | IGF1RA;IGF1RB;INSRA;IGF1R;INSRB;JAK2;INSRR;INSR;PIK3R1 |
insulin-like growth factor I binding | IGF1R;IGFBP3;IGFBP5A;IGFBP5;IGFBP2A;IGFBP5B;IGFBP2;IGFBP1B;IGFBP6B |
insulin-like growth factor binding | HTRA3;WISP3;NOV;IGFBP6B;CTGF;DEFB126;KAZALD1;IGFALS;HTRA1B |
insulin-like growth factor-activated receptor activity | IGF2R;IGF1R |
phosphatidylinositol 3-kinase binding | IGF1RA;ATP1A1;CALM3;HCST;LCK;PDGFRB;IRS1;FYN;JAK2 |
protein binding | MS4A1;PHOSPHO2-KLHL23;HHLA3;TCF7L1A;MED29;ELMO2;NLRX1;DYNLRB1;TRIM37 |
protein tyrosine kinase activity | DYRK1B;EGFRA;FGFR1A;TNK2;RET;EK1;JAK2;ERBB4A;KIT |
IGF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1R.
YWHAB; PIK3R1; PTPN1; ARHGEF12
Gene Family
Research Area
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Q&As (7)
Ask a questionIGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.
Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.
IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.
There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.
Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.
Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.
IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.
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