IGF1R

  • Official Full Name

    insulin-like growth factor 1 receptor

  • Overview

    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
  • Synonyms

    IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Chicken
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Human
  • Mouse
  • Porcine
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Xenopus laevis (African clawed frog)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • DDK
  • DDK|His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Strep
  • His|GST
  • His|T7
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGF1R-107H Active Recombinant Human IGF1R(959-end) Protein, N-His-tagged Sf21 His 959-end
Human IGF1R-106H Activated Recombinant Human IGF1R(959-end) Protein, N-His-tagged Sf21 His 959-end
Human IGF1R-134H Recombinant Human IGF1R protein, DDK-tagged Insect Cell DDK
Human IGF1R-50H Active Recombinant Human IGF1R protein, His&GST-tagged Insect Cells His/GST Met954-Cys1367
Human IGF1R-29114TH Recombinant Human IGF1R E.coli N/A
Human IGF1R-29118TH Recombinant Human IGF1R N/A
Human IGF1R-180H Active Recombinant Human IGF1R protein, His-tagged HEK293 His Met1-Asn932
Human IGF1R-3148H Recombinant Human IGF1R, His tagged Human Cell His
Human IGF1R-29115TH Recombinant Human IGF1R, His-tagged His
Human IGF1R-1631H Recombinant Human Insulin-Like Growth Factor 1 Receptor Mammalian cells N/A
Human IGF1R-663H Recombinant Human Insulin-Like Growth Factor 1 Receptor Human N/A
Human IGF1R-2654H Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His S.frugiperda His/GST
Human IGF1R-51H Recombinant Human IGF1R protein, Flag-tagged, Biotinylated Insect Cell Flag
Human IGF1R-330H Recombinant Human Insulin-like Growth Factor 1 Receptor, His-tagged, Active Sf9 Insect Cell GST
Human IGF1R-214H Recombinant Human IGF1R protein, DDK/His-tagged HEK293 DDK/His Asp741-His935
Human IGF1R-1769H Recombinant Human IGF1R protein, His & T7-tagged E.coli His/T7 Tyr763~Leu955 (Accession # P08069)
Human IGF1R-2928HCL Recombinant Human IGF1R cell lysate Human Cell N/A
Human IGF1R-3148HF Recombinant Human IGF1R Protein, His-tagged, FITC conjugated HEK293 His
Human IGF1R-1391H Recombinant Human IGF1R Protein, DDK-tagged Insect Cell DDK
Human IGF1R-1392H Recombinant Human IGF1R Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IGF1R-3148HAF488 Recombinant Human IGF1R Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human IGF1R-063H Recombinant Human IGF1R Protein, C-His-tagged E.coli C-His
Human IGF1R-393R Active Recombinant Rat IGF1R protein, His-tagged HEK293 His Glu 31 - His 936
Human IGF1R-1154H Recombinant Human IGF1R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IGF1R-50HAF488 Recombinant Human IGF1R Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST 651
Human IGF1R-0995H Recombinant Human IGF1R Protein (S982-K1286), His tagged E.coli His S982-K1286
Human IGF1R-3080H Recombinant Human IGF1R protein, His-tagged E.coli His 763-931aa
Human IGF1R-0285H Active Recombinant Human IGF1R protein, Fc-tagged HEK293 Fc Glu31-Asn932
Human IGF1R-453HFL Recombinant Full Length Human IGF1R Protein, C-Flag-tagged Mammalian cells Flag
Human IGF1R-0996H Recombinant Human IGF1R Protein (S982-K1286), Tag Free E.coli No tag S982-K1286
Human IGF1R-5027H Recombinant Human IGF1R protein, His-tagged HEK293 His 763-931aa
Human IGF1R-169H Recombinant Human IGF1R protein, His-Avi-tagged HEK293 His-Avi It contains Met1-Asn932 .
Human CAB11558MH Mouse Anti-Human Insulin-like Growth Factor 1 Receptor Monoclonal Antibody Mouse N/A
Human IGF1R-595H Recombinant Human IGF1R Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IGF1R-3148HAF555 Recombinant Human IGF1R Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human IGF1R-3079H Recombinant Human IGF1R protein, GST-tagged E.coli GST 763-931aa
Human IGF1R-299H Recombinant Human IGF1R Protein, His and Strep-tagged HEK293 His and Strep 1367
Human IGF1R-50HAF555 Recombinant Human IGF1R Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST 651
Human IGF1R-50HAF647 Recombinant Human IGF1R Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST 651
Human IGF1R-3148HAF647 Recombinant Human IGF1R Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human IGF1R-0286H Active Recombinant Human IGF1R protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu31-Asn932
Human IGF1R-2589H Recombinant Human IGF1R protein(761-930 aa), C-His-tagged HEK293 C-His 761-930 aa
Human IGF1R-50HF Recombinant Human IGF1R Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST 651
Human IGF1R-0921H Recombinant Human IGF1R Protein (Asp741-His935), N-His tagged E.coli N-His Asp741-His935
Human IGF1R-5434H Recombinant Human IGF1R protein, His-tagged Yeast His 763-931aa
Human IGF1R-4257H Recombinant Human IGF1R Protein (Met1-Asn932), C-His tagged Mammalian cells C-His Met1-Asn932
Human IGF1R-1154H-B Recombinant Human IGF1R Protein Pre-coupled Magnetic Beads HEK293
Human IGF1R-4258H Recombinant Human IGF1R Protein (Met1-Val492), C-His tagged Mammalian cells C-His Met1-Val492
Human IGF1R-2588H Recombinant Human IGF1R protein(1291-1360 aa), C-His-tagged E.coli C-His 1291-1360 aa
Mouse IGF1R-22M Active Recombinant Mouse IGF1R Protein, His-tagged CHO His
Mouse IGF1R-0288M Active Recombinant Mouse IGF1R protein, His-tagged HEK293 His Glu31-His936
Mouse IGF1R-392M Recombinant Mouse IGF1R protein, His-tagged HEK293 His Met1-His936
Mouse Igf1r-1223M Recombinant Mouse Igf1r Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Igf1r-30R Recombinant Rat Igf1r protein, His-tagged E.coli His Tyr764~Leu956
Rat IGF1R-3004R Recombinant Rat IGF1R Protein Mammalian Cell His
Rat IGF1R-0287R Active Recombinant Rat IGF1R protein, His-tagged HEK293 His Glu31-His936
Rat IGF1R-2660R-B Recombinant Rat IGF1R Protein Pre-coupled Magnetic Beads HEK293
Rat IGF1R-2660R Recombinant Rat IGF1R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine IGF1R-50C Recombinant Canine IGF1R Protein, His-tagged HEK293 His
Cynomolgus IGF1R-2216C Active Recombinant Cynomolgus IGF1R Protein, His-tagged HEK293 His Glu 31 - Asn 932
Cynomolgus IGF1R-391H Recombinant Cynomolgus IGF1R protein, His-tagged HEK293 His 902
Homo sapiens (Human) RFL3772HF Recombinant Full Length Human Insulin-Like Growth Factor 1 Receptor(Igf1R) Protein, His-Tagged E.coli expression system His Full Length (31-736)
Porcine IGF1R-51P Recombinant Porcine IGF1R Protein, His-tagged HEK293 His
Rattus norvegicus (Rat) RFL12998RF Recombinant Full Length Rat Insulin-Like Growth Factor 1 Receptor(Igf1R) Protein, His-Tagged E.coli expression system His Full Length (31-737)
Rhesus Macaque IGF1R-2216R Recombinant Rhesus monkey IGF1R Protein, His-tagged Mammalian Cell His
Rhesus Macaque IGF1R-2037R Recombinant Rhesus Macaque IGF1R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IGF1R-2037R-B Recombinant Rhesus Macaque IGF1R Protein Pre-coupled Magnetic Beads HEK293
Xenopus laevis (African clawed frog) RFL32204XF Recombinant Full Length Xenopus Laevis Insulin-Like Growth Factor 1 Receptor(Igf1R) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-730)
Chicken IGF1R-6589C Recombinant Chicken IGF1R Mammalian Cell His
Kit-1600 IGF1R Functional Assay Kit N/A
Kit-1601 HEK 293 IGF1R Bioassay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IGF1R involved in several pathways and played different roles in them. We selected most pathways IGF1R participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayGRIN2B;PRKCG;SHC2;PRKACB;GNG7;ABL2;RAC1;FGF11;MAPK3
Rap signaling pathwayF2RL3;MRAS;GNAO1;INS;CALM2;INS1;AKT1;PIK3CG;ITGAM
HIF- signaling pathwaySLC2A1;PDHA2;PIK3CG;ANGPT1;ENO1;CUL2;TIMP1;IFNGR1;GM5506
FoxO signaling pathwayPLK3;GADD45G;TGFB2;PLK2B;EP300;FASLG;HOMER2;BRAF;PIK3CG
Oocyte meiosisANAPC2;MAPK12;CDC23;MOS;PPP2R5C;FBXO5;RPS6KA1;PPP2R5E;CAMK2D1
EndocytosisTGFBR1B;ARRB2B;CLTCB;KIT;ASAP1;SMURF2;VPS26BL;PARD6GB;VPS37D
PIK-Akt signaling pathwayTCL1A;IFNA17;HSP90AA1;ITGAV;TLR2;MET;FGF12;ITGA2;GNG5
AMPK signaling pathwayRAB8A;PPP2R5E;MAP3K7;SCD;LEP;GYS2;PFKFB4;G6PC2;TBC1D1
Focal adhesionCOL4A1;PGF;RAF1A;PARVB;COL6A6;RHOA;PDGFC;LAMA3;PIK3R1
Adherens junctionRAC2;ACTN4;CSNK2B;CSNK2A1;CREBBP;TGFBR1A;VCL;ACTG1;PVRL4
Signaling pathways regulating pluripotency of stem cellsPCGF6;MAP2K2;FZD8;FZD3;LIFR;FZD9;FGF2;NANOG;WNT9A
Long-term depressionIGF1;ITPR3;GUCY1A3;NOS1;PRKCG;GRIA2;PPP1R17;RYR1;MAP2K1
Ovarian steroidogenesisPRKACA;IGF1;HSD17B2;IGF1R;HSD3B5;ALOX5;HSD3B4;CYP2J6;LHCGR
Progesterone-mediated oocyte maturationGNAI2A;ARAF;PRKACAA;PIK3R3;MAPK1;MAPK3;RPS6KA3;CPEB2;MAD1L1
Pathways in cancerAPC2;PTCH1;LAMB1;CTNNA3;ITGA2B;GNG7;TRAF2;WNT3A;PTGER3
Transcriptional misregulation in cancerTLX1;CD86;CCNT2;WNT16;RXRB;RUNX2;HIST3H3;ETV4;HIST1H3I
Proteoglycans in cancerPDCD4;SOS1;MDM2;CBL;WNT10B;GPC1;TGFB2;ERBB3;VEGFA
GliomaBRAF;PIK3CD;IGF1;SHC4;CALM3;CAMK2B;HRAS;CALM4;CALML3
Prostate cancerNKX3-1;NRAS;FOXO1;MAP2K2;NFKBIA;AKT2;ATF4;PIK3CA;MAP4K1
MelanomaPIK3CD;FGF4;PDGFRB;FGFR1;IGF1;PDGFA;PDGFRA;NRAS;MET

IGF1R has several biochemical functions, for example, ATP binding, G-protein alpha-subunit binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1R itself. We selected most functions IGF1R had, and list some proteins which have the same functions with IGF1R. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRUVBL1;HSPA5;ADCY7;ATP1A1B;DDX41;CDC7;P2RX3;CSNK1G3;MAPK8A
G-protein alpha-subunit bindingLPAR1;DRD1;NUCB1;HTR2B;F2R;RIC8;RIC8B;OPRM1;RGS4
identical protein bindingBNIP3L;TRA@;ZNF212;NDE1;PHYKPL;PCBD1;PLIN5;HOOK1;HJURP
insulin bindingIDE;IGF1R;PIK3R1;C2CD2L;HSPD1;INSR
insulin receptor bindingINS;LMBRD1;IGF2;IRS1;DOK7;FRS2A;DOK5;INS2;DOK1B
insulin receptor substrate bindingJAK2;IGF1RA;INSRA;IGF1RB;INSR;PTPN11;IGF1R;PIK3CB;PRKCZ
insulin-like growth factor I bindingIGFBP2A;IGFBP5B;INSR;IGFBP6B;IGFBP6;IGFBP1B;IGFBP3;IGFBP6A;IGFBP5A
insulin-like growth factor bindingIGF1RA;IGFALS;WISP1A;IGFBP5A;IGFBP2B;IGFBP2A;IGFBP1A;WISP1;NOV
insulin-like growth factor-activated receptor activityIGF1R;IGF2R
phosphatidylinositol 3-kinase bindingFLT3;IGF1RB;CALM3;INSR;INSRA;JAK2;LCK;HCST;BECN1
protein bindingPCBP1;EFCAB4B;GCG;THOC4;KRTAP3-3;SKAP2;C18orf56;GLMN;RAB8A
protein tyrosine kinase activityFGFR4;EK1;TNK2B;MET;HCK;MATK;NTRK2B;KDR;IGF1R

IGF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1R.

YWHAB; PIK3R1; PTPN1; ARHGEF12

Gene Family

Cytokines

Research Area

Related articles

Huang, CT; Chang, MC; et al. Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. CANCER LETTERS 359:117-126(2015).
Wang, YX; Zhu, LY; et al. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17 beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1382-E1391(2015).
  • Q&As
  • Reviews

Q&As (7)

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In which cellular compartments is IGF1R predominantly localized? 04/06/2022

IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival? 04/27/2021

Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation? 04/09/2020

IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling? 09/06/2019

There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R? 09/24/2018

Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling? 10/03/2016

Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation? 02/11/2016

IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.

Customer Reviews (3)

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Reviews
07/08/2022

    The product's exceptional purity facilitated precise quantification, ensuring data consistency.

    06/14/2019

      The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

      04/29/2018

        The product's consistent performance bolstered the dependability of our research conclusions.

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