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Recombinant Human IGF1R Protein, His and Strep-tagged

Cat.No. : IGF1R-299H
Product Overview : Recombinant human IGF1R protein with His and Strep tag was expressed in HEK293.
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Description : This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : His&Strep
Form : Lyophilized
Molecular Mass : 104 kDa (single chain), 81 kDa (伪 subunit) & 23 kDa (尾 subunit)
Protein length : 1367
AA Sequence : MKSGSGGGSPTSLWGLLFLSAALSL WPTSGEICGPGIDIRNDYQQLKRLE NCTVIEGYLHILLISKAEDYRSYRF PKLTVITEYLLLFRVAGLESLGDLF PNLTVIRGWKLFYNYALVIFEMTNL KDIGLYNLRNITRGAIRIEKNADLC YLSTVDWSLILDAVSNNYIVGNKPP KECGDLCPGTMEEKPMCEKTTINNE YNYRCWTTNRCQKMCPSTCGKRACT ENNECCHPECLGSCSAPDNDTACVA CRHYYYAGVCVPACPPNTYRFEGWR CVDRDFCANILSAESSDSEGFVIHD GECMQECPSGFIRNGSQSMYCIPCE GPCPKVCEEEKKTKTIDSVTSAQML QGCTIFKGNLLINIRRGNNIASELE NFMGLIEVVTGYVKIRHSHALVSLS FLKNLRLILGEEQLEGNYSFYVLDN QNLQQLWDWDHRNLTIKAGKMYFAF NPKLCVSEIYRMEEVTGTKGRQSKG DINTRNNGERASCESDVLHFTSTTT SKNRIIITWHRYRPPDYRDLISFTV YYKEAPFKNVTEYDGQDACGSNSWN MVDVDLPPNKDVEPGILLHGLKPWT QYAVYVKAVTLTMVENDHIRGAKSE ILYIRTNASVPSIPLDVLSASNSSS QLIVKWNPPSLPNGNLSYYIVRWQR QPQDGYLYRHNYCSKDKIPIRKYAD GTIDIEEVTENPKTEVCGGEKGPCC ACPKTEAEKQAEKEEAEYRKVFENF LHNSIFVPRPERKRRDVMQVANTTM SSRSRNTTAADTYNITDPEELETEY PFFESRVDNKERTVISNLRPFTLYR IDIHSCNHEAEKLGCSASNFVFART MPAEGADDIPGPVTWEPRPENSIFL KWPEPENPNGLILMYEIKYGSQVED QRECVSRQEYRKYGGAKLNRLNPGN YTARIQATSLSGNGSWTDPVFFYVQ AKTGYENFIHLIIALPVAVLLIVGG LVIMLYVFHRKRNNSRLGNGVLYAS VNPEYFSAADVYVPDEWEVAREKIT MSRELGQGSFGMVYEGVAKGVVKDE PETRVAIKTVNEAASMRERIEFLNE ASVMKEFNCHHVVRLLGVVSQGQPT LVIMELMTRGDLKSYLRSLRPEMEN NPVLAPPSLSKMIQMAGEIADGMAY LNANKFVHRDLAARNCMVAEDFTVK IGDFGMTRDIYETDYYRKGGKGLLP VRWMSPESLKDGVFTTYSDVWSFGV VLWEIATLAEQPYQGLSNEQVLRFV MEGGLLDKPDNCPDMLFELMRMCWQ YNPKMRPSFLEIISSIKEEMEPGFR EVSFYYSEENKLPEPEELDLEPENM ESVPLDPSASSSSLPLPDRHSGHKA ENGPGPGVLVLRASFDERQPYAHMN GGRKNERALPLPQSSTC
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens (human) ]
Official Symbol : IGF1R
Synonyms : IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
Gene ID : 3480
mRNA Refseq : NM_000875
Protein Refseq : NP_000866
MIM : 147370
UniProt ID : P08069

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
07/08/2022

    The product's exceptional purity facilitated precise quantification, ensuring data consistency.

    06/14/2019

      The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

      04/29/2018

        The product's consistent performance bolstered the dependability of our research conclusions.

        Q&As (7)

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        In which cellular compartments is IGF1R predominantly localized? 04/06/2022

        IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

        Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival? 04/27/2021

        Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

        How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation? 04/09/2020

        IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

        Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling? 09/06/2019

        There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

        What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R? 09/24/2018

        Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

        What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling? 10/03/2016

        Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

        How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation? 02/11/2016

        IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.

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