| Description : |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His and Strep |
| Form : |
Lyophilized |
| Molecular Mass : |
104 kDa (single chain), 81 kDa (伪 subunit) & 23 kDa (尾 subunit) |
| Protein Length : |
1367 |
| AA Sequence : |
MKSGSGGGSPTSLWGLLFLSAALSL WPTSGEICGPGIDIRNDYQQLKRLE NCTVIEGYLHILLISKAEDYRSYRF PKLTVITEYLLLFRVAGLESLGDLF PNLTVIRGWKLFYNYALVIFEMTNL KDIGLYNLRNITRGAIRIEKNADLC YLSTVDWSLILDAVSNNYIVGNKPP KECGDLCPGTMEEKPMCEKTTINNE YNYRCWTTNRCQKMCPSTCGKRACT ENNECCHPECLGSCSAPDNDTACVA CRHYYYAGVCVPACPPNTYRFEGWR CVDRDFCANILSAESSDSEGFVIHD GECMQECPSGFIRNGSQSMYCIPCE GPCPKVCEEEKKTKTIDSVTSAQML QGCTIFKGNLLINIRRGNNIASELE NFMGLIEVVTGYVKIRHSHALVSLS FLKNLRLILGEEQLEGNYSFYVLDN QNLQQLWDWDHRNLTIKAGKMYFAF NPKLCVSEIYRMEEVTGTKGRQSKG DINTRNNGERASCESDVLHFTSTTT SKNRIIITWHRYRPPDYRDLISFTV YYKEAPFKNVTEYDGQDACGSNSWN MVDVDLPPNKDVEPGILLHGLKPWT QYAVYVKAVTLTMVENDHIRGAKSE ILYIRTNASVPSIPLDVLSASNSSS QLIVKWNPPSLPNGNLSYYIVRWQR QPQDGYLYRHNYCSKDKIPIRKYAD GTIDIEEVTENPKTEVCGGEKGPCC ACPKTEAEKQAEKEEAEYRKVFENF LHNSIFVPRPERKRRDVMQVANTTM SSRSRNTTAADTYNITDPEELETEY PFFESRVDNKERTVISNLRPFTLYR IDIHSCNHEAEKLGCSASNFVFART MPAEGADDIPGPVTWEPRPENSIFL KWPEPENPNGLILMYEIKYGSQVED QRECVSRQEYRKYGGAKLNRLNPGN YTARIQATSLSGNGSWTDPVFFYVQ AKTGYENFIHLIIALPVAVLLIVGG LVIMLYVFHRKRNNSRLGNGVLYAS VNPEYFSAADVYVPDEWEVAREKIT MSRELGQGSFGMVYEGVAKGVVKDE PETRVAIKTVNEAASMRERIEFLNE ASVMKEFNCHHVVRLLGVVSQGQPT LVIMELMTRGDLKSYLRSLRPEMEN NPVLAPPSLSKMIQMAGEIADGMAY LNANKFVHRDLAARNCMVAEDFTVK IGDFGMTRDIYETDYYRKGGKGLLP VRWMSPESLKDGVFTTYSDVWSFGV VLWEIATLAEQPYQGLSNEQVLRFV MEGGLLDKPDNCPDMLFELMRMCWQ YNPKMRPSFLEIISSIKEEMEPGFR EVSFYYSEENKLPEPEELDLEPENM ESVPLDPSASSSSLPLPDRHSGHKA ENGPGPGVLVLRASFDERQPYAHMN GGRKNERALPLPQSSTC |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
