Recombinant Human IL10RA protein, MYC/DDK-tagged
Cat.No. : | IL10RA-9302H |
Product Overview : | Recombinant Human IL10RA, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 60.8 kDa |
Protein length : | Predicted Molecular Mass: 150.4 (monomer) & 55.9 (truncated) kDa;SDS-PAGE: 210-225 kDa, reducing conditions. |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | IL10RA interleukin 10 receptor, alpha [ Homo sapiens ] |
Official Symbol : | IL10RA |
Synonyms : | IL10RA; interleukin 10 receptor, alpha; IL10R; interleukin-10 receptor subunit alpha; CD210; CD210a; CDW210A; HIL 10R; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain; HIL-10R; IL-10R1; |
Gene ID : | 3587 |
mRNA Refseq : | NM_001558 |
Protein Refseq : | NP_001549 |
MIM : | 146933 |
UniProt ID : | Q13651 |
Chromosome Location : | 11q23 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Toxoplasmosis, organism-specific biosystem; Toxoplasmosis, conserved biosystem; Tuberculosis, organism-specific biosystem; |
Function : | interleukin-10 receptor activity; protein binding; receptor activity; signal transducer activity; |
Products Types
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IL10RA-2859H | Recombinant Human IL10RA protein(291-370 aa), C-His-tagged | +Inquiry |
Il10ra-1658M | Recombinant Mouse Il10ra Protein, His-tagged | +Inquiry |
IL10RA-002H | Active Recombinant Human IL10RA Protein | +Inquiry |
◆ Lysates | ||
IL10RA-1185CCL | Recombinant Cynomolgus IL10RA cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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