Recombinant Human IL11

• Cat.No.: IL11-29630TH
• Product Overview: Highly pure (>98%) recombinant hIL-11 (human Interleukin-11)

Specification

• Description: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
• Source: E. coli
• Form: Lyophilised:Reconstitute to a concentration of 0.5mg/ml using 20ul sterile water.
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: Recombinant Human IL-11 is a 19.1 kDa protein containing 179 amino acid residues:MPGPPPGPPRVSPDPRAELDSTVLL TRSLLADTRQLAAQLRDKFPADGDH NLDSLPTLAMSAGALGALQLPGVLT RLRADLLSYLRHVQWLRRAGGSSLK TLEPEL GTLQARLDRLLRRLQLLMSRLALPQ PPPDPPAPPLAP PSSAWGGIRAAHAILGGLHLTLDWA VRGLLLLKTRL
• Sequence Similarities: Belongs to the IL-6 superfamily.

Gene Information

• Gene Name: IL11 interleukin 11 [ Homo sapiens ]
• Official Symbol: IL11
• Synonyms: IL11; interleukin 11; interleukin-11; adipogenesis inhibitory factor; AGIF; IL 11; oprelvekin
• Gene ID: 3589
• mRNA Refseq: NM_000641
• Protein Refseq: NP_000632
• MIM: 147681
• Uniprot ID: P20809
• Chromosome Location: 19q13.3-q13.4
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem
• Function: cytokine activity; growth factor activity; interleukin-11 receptor binding