Active Recombinant Mouse Il11 Protein
|Product Overview :||Recombinant Mouse Il11 Protein without tag was expressed in HEK 293.|
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|Description :||Interleukin-11 (IL-11) is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1α-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.|
|Source :||HEK 293|
|Form :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Bio-activity :||ED50 < 3 ng/mL, measured in a cell proliferation assay using T11 cells.|
|Molecular Mass :||~21 kDa, observed by reducing SDS-PAGE.|
|AA Sequence :||GPPAGSPRVSSDPRADLDSAVLLTR SLLADTRQLAAQMRDKFPADGDHSL DSLPTLAMSAGTLGSLQLPGVLTRL RVDLMSYLRHVQWLRRAGGPSLKTL EPELGALQARLERLLRRLQLLMSRL ALPQAAPDQPVIPLGPPASAWGSIR AAHAILGGLHLTLDWAVRGLLLLKT RL|
|Endotoxin :||< 0.2 EU/μg, determined by LAL method.|
|Purity :||> 95% as analyzed by SDS-PAGE and HPLC.|
|Storage :||Lyophilized recombinant Murine Interleukin-11 (IL-11) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Murine Interleukin-11 (IL-11) should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.|
|Storage Buffer :||Lyophilized after extensive dialysis against PBS.|
|Reconstitution :||Reconstituted in ddH2O or PBS at 100 μg/mL.|
|Gene Name :||Il11 interleukin 11 [ Mus musculus ]|
|Official Symbol :||Il11|
|Synonyms :||IL11; interleukin 11; interleukin-11; IL-11;|
|Gene ID :||16156|
|mRNA Refseq :||NM_008350|
|Protein Refseq :||NP_032376|
|UniProt ID :||P47873|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Transgenic mice and knockdown models explore IL11's impact on tissue regeneration.
Site-directed mutagenesis identifies key residues in IL11's interaction with IL11RA.
Chromatin immunoprecipitation and DNA methylation analysis decipher IL11's regulatory mechanisms.
Proteomics identifies IL11-interacting proteins and potential cross-talk partners.
Cell-based and luciferase reporter assays elucidate IL11's JAK-STAT signaling activation.
RNA sequencing uncovers IL11-induced gene expression changes across different cell types.
X-ray crystallography and NMR spectroscopy reveal structural details of the IL11-IL11RA complex.
Confocal and super-resolution microscopy visualize IL11 localization in tissues.
Techniques like surface plasmon resonance measure IL11-IL11RA binding affinity and kinetics.
CRISPR screening unveils genes and pathways influenced by IL11 signaling.
Customer Reviews (3)Write a review
Potent in bone regeneration models. -
Suitable for cell culture. -
High yield in expression. -
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