| Description : |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
38.6 kDa |
| Protein Length : |
398 |
| AA Sequence : |
MLRLYVLVMGVSAFTLQPAAHTGAA RSCRFRGRHYKREFRLEGEPVALRC PQVPYWLWASVSPRINLTWHKNDSA RTVPGEEETRMWAQDGALWLLPALQ EDSGTYVCTTRNASYCDKMSIELRV FENTDAFLPFISYPQILTLSTSGVL VCPDLSEFTRDKTDVKIQWYKDSLL LDKDNEKFLSVRGTTHLLVHDVALE DAGYYRCVLTFAHEGQQYNITRSIE LRIKKKKEETIPVIISPLKTISASL GSRLTIPCKVFLGTGTPLTTMLWWT ANDTHIESAYPGGRVTEGPRQEYSE NNENYIEVPLIFDPVTREDLHMDFK CVVHNTLSFQTLRTTVKEASSTFSW GIVLAPLSLAFLVLGGIWMHRRCKH RTGKADGLTVLWPHHQDFQSYPK |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
