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Recombinant Human IL21R, Fc-tagged

Cat.No. : IL21R-340H
Product Overview : The extracellular domain of human IL-21R (aa 20-232) is fused to the N-terminus of the Fc region of human IgG1.
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  • Gene Information
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Description : Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. Complex formation between IL-21R and the common gamma chain (gammac) is required for signaling. IL-21R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells and keratinocytes. B cell IL-21R engagement induces Blimp1 (which mediates plasma cell differentiation) and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).
Source : CHO Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Purity : ≥98% (SDS-PAGE)
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Gene Name : IL21R interleukin 21 receptor [ Homo sapiens ]
Official Symbol : IL21R
Synonyms : IL21R; interleukin 21 receptor; interleukin-21 receptor; CD360; IL-21R; IL-21 receptor; novel interleukin receptor; NILR; MGC10967;
Gene ID : 50615
mRNA Refseq : NM_021798
Protein Refseq : NP_068570
MIM : 605383
UniProt ID : Q9HBE5
Chromosome Location : 16p11
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : interleukin-21 receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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