Recombinant Human IL22 Protein, His-tagged

• Cat.No.: IL22-91H
• Product Overview: Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed with a 6His tag at the C-terminus.

Specification

• Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
• Source: Human Cells
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• AA Sequence: Ala34-Ile179
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient
• Protein length: Ala34-Ile179

Gene Information

• Gene Name: IL22 interleukin 22 [ Homo sapiens (human) ]
• Official Symbol: IL22
• Synonyms: Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL22; ZCYTO18; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• Gene ID: 50616
• mRNA Refseq: NM_020525.5
• Protein Refseq: NP_065386.1
• MIM: 605330
• UniProt ID: Q9GZX6

Reviews

04/07/2021

High specificity.

03/29/2021

Good for Th17 differentiation.

07/07/2016

Effective in gut repair assays.

Q&As

What is IL22's role in gut epithelial repair?

IL22 enhances gut epithelial repair mechanisms.

What are the downstream targets of IL22 signaling?

IL22 activates STAT3 to modulate downstream targets.

How does IL22 interact with other cytokines in inflammation?

IL22 interacts synergistically with IL-17 during inflammation.

Is IL22 involved in the pathogenesis of autoimmune diseases?

IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

Does IL22 have a role in metabolic syndrome?

IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

How is IL22 expression regulated in psoriasis?

IL22 expression is upregulated in psoriasis.

Does IL22 expression change during viral infections?

IL22 expression is upregulated during viral infections like Hepatitis C.

Does IL22 contribute to anti-tumor immunity?

IL22 contributes to anti-tumor immunity by activating NK cells.

How does IL22 modulate T-cell differentiation?

IL22 promotes Th22 cell differentiation.

What impact do IL22 polymorphisms have on its function?

IL22 polymorphisms affect its binding affinity and signaling.