IL22

  • Official Full Name

    interleukin 22

  • Overview

    Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
  • Synonyms

    IL22; interleukin 22; TIFa; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23; IL-10-related T-cell-derived inducible factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Caprine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Sheep
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Hordeum Vulgare
  • Human
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mouse
  • Yeast
  • C
  • 6His
  • His
  • Fc
  • GST
  • hIgG2 Fc
  • Avi
  • His (Fc)
  • His(C
  • ter)
  • HQ
  • mFc
  • Myc
  • DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL22-561H Active Recombinant Human IL22, MIgG2a Fc-tagged CHO Fc
Human IL22-563H Active Recombinant Human IL22, HIgG1 Fc-tagged CHO Fc
Human IL22-562H Active Recombinant Human IL22, HIgG1 Fc-tagged, mutant CHO Fc
Human IL22-461H Active Recombinant Human IL22 protein E.coli N/A Ala34-Ile179
Human IL22-449H Active Recombinant Human IL22 protein, His-tagged Yeast His Ala34-Ile179
Human IL22-002H Active Recombinant Human IL22 Protein, His-tagged Insect Cell His
Human IL22-360I Active Recombinant Human IL22 Protein (147 aa) E.coli 147
Human IL22-1025H Active Recombinant Human IL22 protein, His & Avi-tagged HEK293 His & Avi Ala 34 - Ile 179
Human IL22-215H Recombinant Human IL22, StrepII-tagged Human Cell Strep II 34-179, 146 a.a.
Human IL22-555H Recombinant Human Interleukin 22 Human N/A
Human IL22-15H Recombinant Human IL22 protein, His-tagged HEK293 His Ala34-Ile179
Human IL22-342H Recombinant Human IL22, Fc-tagged CHO Fc
Human IL22-637H Recombinant Human Interleukin 22, HQ-tagged Hordeum Vulgare HQ
Human IL22-14185H Recombinant Human IL22, GST-tagged E.coli GST 28-179a.a.
Human IL22-135H Recombinant Human IL22 protein E.coli N/A 147
Human IL22-5232HCL Recombinant Human IL22 293 Cell Lysate HEK293 N/A
Human IL22-241H Active Recombinant Human IL22 Protein (Ala34-Ile179), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala34-Ile179
Human IL22-177H Recombinant Active Human IL22 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL22-83H Recombinant Human IL22 Protein, hIgG2 Fc-tagged Human Cell hIgG2 Fc Ala34-Ile179
Human IL22-3582H Recombinant Human IL22 Protein (Ala34-Ile179), C-His tagged E.coli C-His Ala34-Ile179
Human IL22-44H Recombinant Human IL22 Protein, C-6His tagged, Biotinylated HEK293 C-6His A34-I179
Human IL22-433HG Active GMP Recombinant Human IL22 protein CHO
Human IL22-1852H Active Recombinant Human IL22 protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Ala 34 - Ile 179
Human IL22-163H Recombinant Human IL22 Protein E.coli
Human IL22-217H Recombinant Human IL22 Protein, His-tagged HEK293 His
Human IL22-435HG Active GMP Recombinant Human IL22 protein HEK293 DNA sequence encoding Human IL-22(NP_065386.1) was expressed with His tag at the C-terminal.
Human IL22-512H Recombinant Human IL22 Protein 179
Human IL22-73H Recombinant Human IL22 Protein E.coli
Human IL22-178I Active Recombinant Human IL22 Protein HEK293
Human IL22-5005H Recombinant Human IL22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL22-91H Recombinant Human IL22 Protein, His-tagged Human Cell His
Human IL22-098I Active Recombinant Human IL22 Protein (146 aa) E.coli 146
Human IL22-4335HG Active GMP Recombinant Human IL22 protein E.coli N/A
Human IL22-151H Recombinant Human IL22 Protein, His-tagged Human Cells His
Human IL22-2301H Recombinant Human IL22 Protein, His-tagged E.coli N-His Ala34-Ile179
Mouse IL22-601M Active Recombinant Mouse Interleukin 22, MIgG2a Fc-tagged CHO Fc
Mouse IL22-600M Active Recombinant Mouse IL22, MIgG2a Fc-tagged, mutant CHO Fc
Mouse Il22-439M Active Recombinant Mouse Interleukin 22, PEG-tagged Mouse N/A
Mouse Il22-01M Active Recombinant Mouse Il22 Protein, His-Tagged E.coli His
Mouse Il22-146M Active Recombinant Mouse Il22 Protein E.coli
Mouse Il22-359I Active Recombinant Mouse Il22 Protein (147 aa) E.coli 147
Mouse Il22-549M Recombinant Mouse Il22 protein E.coli N/A 146
Mouse Il22-639M Recombinant Mouse Interleukin 22 E.coli N/A
Mouse IL22-90M Recombinant Mouse IL-22 Yeast N/A
Mouse Il22-28M Recombinant Mouse Interleukin-22 E.coli N/A
Mouse Il22-345M Recombinant Mouse Il22, Fc-tagged CHO Fc
Mouse Il22-344M Recombinant Mouse Il22, His-tagged E.coli His
Mouse Il22-242M Active Recombinant Mouse Il22 Protein (Leu34-Val179), C-His tagged, Animal-free, Carrier-free E.coli C-His Leu34-Val179
Mouse Il22-346M Recombinant Mouse Il22 protein, mFc-tagged HEK293 mFc Leu34-Val179
Mouse Il22-3514M Active Recombinant Mouse Il22 Protein E.coli Leu34-Val179
Mouse Il22-178M Recombinant Active Mouse IL22 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse IL22-164M Active Recombinant Mouse IL22 Protein E.coli
Mouse IL22-105M Recombinant Mouse IL22 Protein E.coli
Mouse Il22-3513M Recombinant Mouse Il22 Protein E.coli Leu34-Val179
Rat Il22-001R Active Recombinant Rat Il22, HIgG1 Fc-tagged CHO Fc
Rat Il22-582R Recombinant Rat Il22 protein E.coli N/A 146
Rat Il22-1673R Recombinant Rat Il22 Protein, His-tagged E.coli N-His Leu34-Val179
Caprine IL22-4349C Recombinant Caprine IL22 Protein Yeast N/A 157aa
Cynomolgus Monkey IL22-4375C Recombinant Cynomolgus Monkey IL22 Protein Yeast N/A 146aa
Rhesus Macaque IL22-2245R Recombinant Rhesus monkey IL22 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL22-2066R-B Recombinant Rhesus Macaque IL22 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL22-2066R Recombinant Rhesus Macaque IL22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep IL22-4348S Recombinant Sheep IL22 Protein Yeast N/A 157aa
Zebrafish IL22-2926Z Recombinant Zebrafish IL22 Mammalian Cell His
Zebrafish IL22-60Z Recombinant Zebrafish IL22 Protein, His-tagged E.coli His
Chicken IL22-4423C Recombinant Chicken IL22 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL22 involved in several pathways and played different roles in them. We selected most pathways IL22 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCR3.1;IFNA10;CXCL10;TNFRSF11B;PPBP;Cxcl15;ACVR2B;GDF5;IL28A
Jak-STAT signaling pathwaySTAT5B;IL-15RA;STAT1B;HRASB;STAM;IFNA16;IFNA1;EP300;IFNB1
Inflammatory bowel disease (IBD)TGFB2;RORA;IL21R;NFATC1;TBX21;TLR2;HLA-DOA;HLA-DRB5;Il23a

IL22 has several biochemical functions, for example, cytokine activity, interleukin-22 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22 itself. We selected most functions IL22 had, and list some proteins which have the same functions with IL22. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCMTM2;IL19;IL1B;TXLNA;OSTN;BMP8B;Ctf2;SPP1;IL29
interleukin-22 receptor bindingIL22;IL20

IL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22.

IL22RA1; IL22RA2

Gene Family

IL

Research Area

Related articles

Akha, AAS; McDermott, AJ; et al. Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice. IMMUNOLOGY 144:587-597(2015).
Ali, IM; Evehe, MSB; et al. Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon. PATHOGENS AND GLOBAL HEALTH 108:323-333(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is IL22's role in gut epithelial repair? 02/05/2022

IL22 enhances gut epithelial repair mechanisms.

What are the downstream targets of IL22 signaling? 12/27/2021

IL22 activates STAT3 to modulate downstream targets.

How does IL22 interact with other cytokines in inflammation? 10/06/2021

IL22 interacts synergistically with IL-17 during inflammation.

Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

Does IL22 have a role in metabolic syndrome? 02/23/2021

IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

How is IL22 expression regulated in psoriasis? 09/05/2018

IL22 expression is upregulated in psoriasis.

Does IL22 expression change during viral infections? 07/26/2018

IL22 expression is upregulated during viral infections like Hepatitis C.

Does IL22 contribute to anti-tumor immunity? 03/14/2018

IL22 contributes to anti-tumor immunity by activating NK cells.

How does IL22 modulate T-cell differentiation? 10/30/2017

IL22 promotes Th22 cell differentiation.

What impact do IL22 polymorphisms have on its function? 09/25/2017

IL22 polymorphisms affect its binding affinity and signaling.

Customer Reviews (3)

Write a review
Reviews
04/07/2021

    High specificity.

    03/29/2021

      Good for Th17 differentiation.

      07/07/2016

        Effective in gut repair assays.

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