IL22 Protein


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Official Full Name interleukin 22
Background Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
Synonyms IL22; interleukin 22; TIFa; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23; IL-10-related T-cell-derived inducible factor
    • Species :
    • Caprine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • His & Avi
    • HQ
    • Myc/DDK
    • N/A
    • N-His
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL22-135H Recombinant Human IL22 protein E.coli N/A
    Human IL22-14185H Recombinant Human IL22, GST-tagged E.coli GST
    Human IL22-15H Recombinant Human IL22 protein, His-tagged HEK293 His
    Human IL22-215H Recombinant Human IL22, StrepII-tagged Human Cell Strep II
    Human IL22-342H Recombinant Human IL22, Fc-tagged CHO Fc
    Human IL22-461H Recombinant Human IL22 E.coli N/A
    Human IL22-555H Recombinant Human Interleukin 22 Human N/A
    Human IL22-561H Recombinant Human IL22, MIgG2a Fc-tagged CHO Fc
    Human IL22-562H Recombinant Human IL22, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL22-563H Recombinant Human IL22, HIgG1 Fc-tagged CHO Fc
    Human IL22-637H Recombinant Human Interleukin 22, HQ-tagged Hordeum Vulgare HQ
    Mouse Il22-28M Recombinant Mouse Interleukin-22 E.coli N/A
    Mouse Il22-344M Recombinant Mouse Il22, His-tagged E.coli His
    Mouse Il22-345M Recombinant Mouse Il22, Fc-tagged CHO Fc
    Mouse Il22-439M Recombinant Mouse Interleukin 22, PEG-tagged Mouse N/A
    Mouse Il22-549M Recombinant Mouse Il22 protein E.coli N/A
    Mouse IL22-600M Recombinant Mouse IL22, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse IL22-601M Recombinant Mouse Interleukin 22, MIgG2a Fc-tagged CHO Fc
    Mouse Il22-639M Recombinant Mouse Interleukin 22 E.coli N/A
    Mouse IL22-90M Recombinant Mouse IL-22 Yeast N/A
    Rat Il22-001R Recombinant Rat Il22, HIgG1 Fc-tagged CHO Fc
    Rat Il22-582R Recombinant Rat Il22 protein E.coli N/A
    Rhesus Macaque IL22-2245R Recombinant Rhesus monkey IL22 Protein, His-tagged Mammalian Cell His
    Chicken IL22-4423C Recombinant Chicken IL22 Mammalian Cell His
    Zebrafish IL22-2926Z Recombinant Zebrafish IL22 Mammalian Cell His
    Human IL22-5232HCL Recombinant Human IL22 293 Cell Lysate HEK293 N/A
    Human IL22-1025H Recombinant Human IL22 protein, His & Avi-tagged HEK293 His & Avi
    Human IL22-151H Recombinant Human IL22 Protein, His-tagged Human Cells His
    Rat Il22-1673R Recombinant Rat Il22 Protein, His-tagged E.coli N-His
    Human IL22-2301H Recombinant Human IL22 Protein, His-tagged E.coli N-His
    Zebrafish IL22-60Z Recombinant Zebrafish IL22 Protein, His-tagged E.coli His
    Human IL22-002H Recombinant Human IL22 Protein, His-tagged Insect Cell His
    Human IL22-4335HG GMP Recombinant Human IL22 protein E.coli N/A
    Human IL22-433HG GMP Recombinant Human IL22 protein CHO
    Human IL22-435HG GMP Recombinant Human IL22 protein, His-tagged HEK293 His
    Human IL22-449H Recombinant Human IL22 Protein, His-tagged Yeast His
    Human IL22-5005H Recombinant Human IL22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Il22-146M Recombinant Mouse Il22 Protein E.coli
    Mouse Il22-3513M Recombinant Mouse Il22 Protein E. coli
    Mouse Il22-3514M Recombinant Mouse Il22 Protein E. coli
    Cynomolgus Monkey IL22-4375C Recombinant Cynomolgus Monkey IL22 Protein Yeast N/A
    Sheep IL22-4348S Recombinant Sheep IL22 Protein Yeast N/A
    Caprine IL22-4349C Recombinant Caprine IL22 Protein Yeast N/A

    IL22 involved in several pathways and played different roles in them. We selected most pathways IL22 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL28; IL13; Ccl27a; Flt3l; IL24; PRL2; PRP2; IL9R; LEPR; FIGF
    Jak-STAT signaling pathway IL3RA; SOCS4; IL22RA2; IL12B; OSM; MTOR; IL2RGA; IL13RA1; IFNA4; IL10RB
    Inflammatory bowel disease (IBD) HLA-DMB; TLR4; IL18RAP; IL1B; SMAD2; TGFB2; IL4R; TNF; Il23a; H2-AA

    IL22 has several biochemical functions, for example, cytokine activity, interleukin-22 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22 itself. We selected most functions IL22 had, and list some proteins which have the same functions with IL22. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CMTM5; LEFTY2; GDF5; TIMP1; GDF10; IFNA8; CCL20B; GPR19; IL13; WNT2
    interleukin-22 receptor binding IL20; IL22

    IL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22.

    IL22RA1; IL22RA2

    Akha, AAS; McDermott, AJ; et al. Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice. IMMUNOLOGY 144:587-597(2015).
    Ali, IM; Evehe, MSB; et al. Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon. PATHOGENS AND GLOBAL HEALTH 108:323-333(2014).


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