IL22
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Official Full Name
interleukin 22 -
Overview
Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A. -
Synonyms
IL22;interleukin 22;TIFa;IL-22;ILTIF;IL-TIF;IL-D110;zcyto18;MGC79382;MGC79384;TIFIL-23;IL-10-related T-cell-derived inducible factor
Recombinant Proteins
- Human
- Sheep
- Goat
- Cynomolgus
- Zebrafish
- Rat
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Yeast
- CHO
- Mouse
- Insect Cells
- HEK293
- C-His
- Mammalian Cells
- Human
- Hordeum Vulgare
- Human Cells
- GST
- Non
- His
- Fc
- Avi
- HQ
- Flag
- mFc
- DDK
- Myc
- hIgG2
Involved Pathway
IL22 involved in several pathways and played different roles in them. We selected most pathways IL22 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR9A,FAS,CCL7,CXCL8B.3,CXCL8,BMPR1AB,M17,CX3CR1,IL18RAP,TNFB |
| Inflammatory bowel disease (IBD) | IL13,IFNGR1,IL18R1,IL1B,IL5,IL17A,IL4R,Il2,IL23R,H2-AB1 |
| Jak-STAT signaling pathway | IL29,OSMR,IL3RA,SOCS6,IFNA5,RAF1,IL11RA,PIAS4A,IL2RGA,IL22RA1 |
Protein Function
IL22 has several biochemical functions, for example, cytokine activity,interleukin-22 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22 itself. We selected most functions IL22 had, and list some proteins which have the same functions with IL22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-22 receptor binding | IL20 |
| cytokine activity | VSTM1,IFNE,Ifna15,GM13279,IL15L,Flt3l,SPAW,IL37,GREM1,SP100 |
Interacting Protein
IL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22.
IL22RA1;IL22RA2
Resources
Research Area
Inflammatory Cytokines & ChemokinesInflammatory Mediators
gamma delta T Cells
Natural Killer T (NKT) Cells
Th17 Cells
Th22 Cells
IL-10 Family Ligands
Related Services
Related Products
References
- Akha, AAS; McDermott, AJ; et al. Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice. IMMUNOLOGY 144:587-597(2015).
- Ali, IM; Evehe, MSB; et al. Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon. PATHOGENS AND GLOBAL HEALTH 108:323-333(2014).
