Recombinant Human IL22 protein, His-tagged
Cat.No. : | IL22-15H |
Product Overview : | Recombinant Human IL22 (Ala34-Ile179) protein was fused to His-tag at N-terminus and expressed in human 293 cells (HEK293). |
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Description : | Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ala34 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Ala34-Ile179 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL22 |
Official Symbol : | IL22 |
Synonyms : | IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23 |
Gene ID : | 50616 |
mRNA Refseq : | NM_020525 |
Protein Refseq : | NP_065386 |
MIM : | 605330 |
UniProt ID : | Q9GZX6 |
Products Types
◆ Recombinant Protein | ||
IL22-360I | Active Recombinant Human IL22 Protein (147 aa) | +Inquiry |
Il22-178M | Recombinant Active Mouse IL22 Protein, His-tagged(C-ter) | +Inquiry |
IL22-163H | Recombinant Human IL22 Protein | +Inquiry |
IL22-2066R | Recombinant Rhesus Macaque IL22 Protein, His (Fc)-Avi-tagged | +Inquiry |
Il22-146M | Active Recombinant Mouse Il22 Protein | +Inquiry |
◆ Lysates | ||
IL22-5232HCL | Recombinant Human IL22 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)
Write a reviewHigh specificity.
Good for Th17 differentiation.
Effective in gut repair assays.
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