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Recombinant Human IL22 protein, His-tagged

Cat.No. : IL22-15H
Product Overview : Recombinant Human IL22 (Ala34-Ile179) protein was fused to His-tag at N-terminus and expressed in human 293 cells (HEK293).
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Description : Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ala34
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ala34-Ile179
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL22
Official Symbol : IL22
Synonyms : IL22; interleukin 22; interleukin-22; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; ILTIF; MGC79382; MGC79384; TIFa; TIFIL 23; zcyto18; cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL-22; IL-TIF; IL-D110; TIFIL-23
Gene ID : 50616
mRNA Refseq : NM_020525
Protein Refseq : NP_065386
MIM : 605330
UniProt ID : Q9GZX6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is IL22's role in gut epithelial repair? 02/05/2022

IL22 enhances gut epithelial repair mechanisms.

What are the downstream targets of IL22 signaling? 12/27/2021

IL22 activates STAT3 to modulate downstream targets.

How does IL22 interact with other cytokines in inflammation? 10/06/2021

IL22 interacts synergistically with IL-17 during inflammation.

Is IL22 involved in the pathogenesis of autoimmune diseases? 06/25/2021

IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.

Does IL22 have a role in metabolic syndrome? 02/23/2021

IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.

How is IL22 expression regulated in psoriasis? 09/05/2018

IL22 expression is upregulated in psoriasis.

Does IL22 expression change during viral infections? 07/26/2018

IL22 expression is upregulated during viral infections like Hepatitis C.

Does IL22 contribute to anti-tumor immunity? 03/14/2018

IL22 contributes to anti-tumor immunity by activating NK cells.

How does IL22 modulate T-cell differentiation? 10/30/2017

IL22 promotes Th22 cell differentiation.

What impact do IL22 polymorphisms have on its function? 09/25/2017

IL22 polymorphisms affect its binding affinity and signaling.

Customer Reviews (3)

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Reviews
04/07/2021

    High specificity.

    03/29/2021

      Good for Th17 differentiation.

      07/07/2016

        Effective in gut repair assays.

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