Recombinant Human IL23A
Cat.No. : | IL23A-29782TH |
Product Overview : | Recombinant Human IL23 is a heterodimeric protein consisting of two subunits, p19 and p40 ; MWt 53.5 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. |
Molecular Weight : | 53.500kDa |
Source : | High-5 insect cells |
Tissue specificity : | Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). |
Biological activity : | Biological activity measured by the ability to induce IL-17 secretion by mouse splenocytes. |
Form : | Lyophilised:Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer co |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 1X PBS, pH 7.2 |
Storage : | The lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles. See reconstitution notes |
Sequences of amino acids : | RAVPGGSSPAWTQCQQLSQKLCTLA WSAHPLVGHMDLREEGDEETTNDVP HIQCGDGCDPQGLRDNSQFCLQRIH QGLIFYEKLLGSDIFTGEPSLLPDS PVGQLHASLLGLSQLLQPEGHHWET QQIPSLSPSQPWQRLLLRFKILRSL QAFVAVAARVFAHGAATLSPIWELK KDVYVVELDWYPDAPGEMVVLTCDT PEEDGITWTLDQSSEVLGSGKTLTI QVKEFGDAGQYTCHKGGEVLSHSLL LLHKKEDGIWSTDILKDQKEPKNKT FLRCEAKNYSGRFTCWWLTTISTDL TFSVKSSRGSSDPQGVTCGAATLSA ERVRGDNKEYEYSVECQEDSACPAA EESLPIEVMVDAVHKLKYENYTSSF FIRDIIKPDPPKNLQLKPLKNSRQV EVSWEYPDTWSTPHSYFSLTFCVQV QGKSKREKKDRVFTDKTSATVICRK NASISVRAQDRYYSSSWSEWASVPC S |
Sequence Similarities : | Belongs to the IL-6 superfamily. |
Gene Name : | IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ] |
Official Symbol : | IL23A |
Synonyms : | IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; |
Gene ID : | 51561 |
mRNA Refseq : | NM_016584 |
Protein Refseq : | NP_057668 |
MIM : | 605580 |
Uniprot ID : | Q9NPF7 |
Chromosome Location : | 12q13.13 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; |
Function : | cytokine activity; contributes_to interleukin-23 receptor binding; |
Products Types
◆ Recombinant Protein | ||
Il23a-2305M | Recombinant Mouse Il23a Protein, His-tagged | +Inquiry |
IL23A-2696R | Recombinant Rat IL23A Protein, His (Fc)-Avi-tagged | +Inquiry |
Il23a-2304M | Recombinant Mouse Il23a Protein, His-tagged | +Inquiry |
IL23A-05H | Active Recombinant Human IL-23 Protein | +Inquiry |
IL23A-02H | Recombinant Human Active IL23A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL23A-5231HCL | Recombinant Human IL23A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (6)
Ask a questionPlease inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
Customer Reviews (3)
Write a reviewCoupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
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