il23a

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il23a

Official Full Name interleukin 23, alpha subunit p19
Background Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of multiple sclerosis and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway.
Synonyms IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation
    • Species :
    • Bovine
    • Cynomolgus Monkey
    • Human
    • Marmoset
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Spodoptera Frugiperda
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Flag
    • GST
    • His
    • Avi
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL23A-451H Recombinant Human IL23A Protein, Fc-tagged HEK293 Fc
    Human Il23A-001H Recombinant Human Il23A, HIgG1 Fc-tagged, mutant CHO Fc
    Human Il23A-002H Recombinant Human Il23A, MIgG2a Fc-tagged CHO Fc
    Human Il23A-003H Recombinant Human Il23A, HIgG1 Fc-tagged CHO Fc
    Human Il23A-053H Recombinant Human Il23A protein, GST-tagged Wheat Germ GST
    Human IL23A-1823H Recombinant Human IL23A protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human Il23A-23H Recombinant Human Il23A&IL12B Protein, His-tagged HEK293 His
    Human IL23A-29781TH Recombinant Human IL23A, FLAG-tagged HEK293 Flag
    Human IL23A-29782TH Recombinant Human IL23A Hi-5 Insect Cell N/A
    Human IL23A-5231HCL Recombinant Human IL23A 293 Cell Lysate HEK293 N/A
    Human IL23A-553H Recombinant Human IL23A Protein, His-tagged E.coli His
    Human IL23A-966H Recombinant Human IL23A Protein Hi-5 Insect Cell N/A
    Human IL23A-967H Recombinant Human IL23A Protein Insect Cell N/A
    Human L23A-269H Recombinant Human Iinterleukin 23, Alpha Subunit P19 HEK293 N/A
    Mouse IL23A-159M Recombinant Mouse Il23a & Il12b, His tagged Human Cell His
    Mouse Il23a-1784M Recombinant Mouse Il23a protein, His & SUMO-tagged E.coli His/SUMO
    Mouse Il23a-1927M Recombinant Mouse Il23a Protein Insect Cell N/A
    Mouse Il23a-651M Recombinant Mouse Interleukin 23, Alpha Subunit P19 Spodoptera Frugiperda N/A
    Mouse IL23A-8156M Recombinant Mouse IL23A Protein Mammalian Cell His
    Rat Il12b&Il23a-747R Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A
    Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A
    Rat IL23A-3041R Recombinant Rat IL23A Protein Mammalian Cell His
    Cynomolgus Monkey IL23A-617C Recombinant Cynomolgus IL23A Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL23A-2246R Recombinant Rhesus monkey IL23A Protein, His-tagged Mammalian Cell His
    Bovine IL23A-239B Recombinant Bovine Interleukin 23, Alpha Subunit P19 Yeast N/A
    Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc

    il23a involved in several pathways and played different roles in them. We selected most pathways il23a participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with il23a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFRSF10A; IL-8; CXCR3.1; Ccl21c; IFNK; TNFRSF12A; BMP7A; IL1R2; CCL28; CCL3L3
    Jak-STAT signaling pathway MPL; AOX3L1; IL24; AKT2L; Il2; IFNG; JAK2B; PIK3CA; NT5C3; PIK3R1
    Pertussis TNF; IRF1; CXCL6; C1R; GNAI2; Il23a; Il12b; SERPING1; C4BPB; CALML5; CALM1
    Tuberculosis ATP6V0C; HLA-DOA; APAF1; CAMK2A; MAPK8; BCL2; ITGAX; FCER1G; MAPK1; PPP3CC
    Inflammatory bowel disease (IBD) IL6; IL17A; HLA-DRB5; HLA-DPA1; RORC; STAT3; Il23a; HLA-DOA; IL17F; HLA-DMB
    Rheumatoid arthritis HLA-DRB3; ATP6V0A1; CXCL5; IFNG; Il23a; Il12b; CCL2; TNFRSF11A; ATP6V1A; CCL5; VEGFA

    il23a has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by il23a itself. We selected most functions il23a had, and list some proteins which have the same functions with il23a. You can find most of the proteins on our site.

    Function Related Protein

    il23a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il23a here. Most of them are supplied by our site. Hope this information will be useful for your research of il23a.

    Masaki, K; Suzuki, Y; et al. Dual Role of Interleukin-23 in Epicutaneously-Sensitized Asthma in Mice. ALLERGOLOGY INTERNATIONAL 63:13-22(2014).
    Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).

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