IL23A

  • Official Full Name

    interleukin 23, alpha subunit p19

  • Overview

    Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of multiple sclerosis and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway.
  • Synonyms

    IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cynomolgus Monkey
  • Guinea pig
  • Human
  • Marmoset
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Hi-5 Insect Cell
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9
  • Spodoptera Frugiperda
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His(N
  • ter)
  • His|Avi
  • His|SUMO
  • SUMO
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL23A-1823H Active Recombinant Human IL23A protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
Human L23A-269H Active Recombinant Human Iinterleukin 23, Alpha Subunit P19 HEK293 N/A
Human Il23A-002H Active Recombinant Human Il23A, MIgG2a Fc-tagged CHO Fc
Human Il23A-001H Active Recombinant Human Il23A, HIgG1 Fc-tagged, mutant CHO Fc
Human Il23A-003H Active Recombinant Human Il23A, HIgG1 Fc-tagged CHO Fc
Human IL23A-966H Active Recombinant Human IL23A Protein Hi-5 Insect Cell N/A
Human IL23A-967H Active Recombinant Human IL23A Protein Insect Cell N/A
Human Il23A-23H Recombinant Human Il23A&IL12B Protein, His-tagged HEK293 His
Human Il23A-053H Recombinant Human Il23A Protein, GST-tagged Wheat Germ GST
Human IL23A-29782TH Recombinant Human IL23A Hi-5 Insect Cell N/A
Human IL23A-553H Recombinant Human IL23A protein, His-tagged E.coli His
Human IL23A-29781TH Recombinant Human IL23A, FLAG-tagged HEK293 Flag
Human IL23A-5231HCL Recombinant Human IL23A 293 Cell Lysate HEK293 N/A
Human IL23A-151H Recombinant Human IL23A Protein, His-tagged Human cells His
Human IL23A-02H Recombinant Human Active IL23A Protein, His-tagged E.coli His
Human IL23A-638H Recombinant Human IL23A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL23A-451H Recombinant Human IL23A Protein, Fc-tagged HEK293 Fc
Human IL23A-32H Active Recombinant Human IL23A Protein, Animal Free Human cells
Human IL23A-1172H-B Recombinant Human IL23A Protein Pre-coupled Magnetic Beads HEK293
Human Il23A-602HF Recombinant Full Length Human Il23A Protein, GST-tagged In Vitro Cell Free System GST
Human IL23A-01H Active Recombinant Human IL23A Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human IL23A-109HFL Active Recombinant Full Length Human IL23A Protein, C-Flag-tagged Mammalian cells Flag
Human IL23A-4844H Recombinant Human IL23A Protein (Met1-Pro189), C-His tagged Mammalian cells C-His
Human IL23A-1172H Recombinant Human IL23A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL23A-2303H Recombinant Human IL23A Protein, His-tagged HEK293F N-His
Human IL23A-05H Active Recombinant Human IL-23 Protein Sf21 Insect Cell
Human IL23A-5832H Recombinant Human IL23 Protein (Arg20-Pro189, Ile23-Ser328), C-His and C-Flag tagged Mammalian cells C-His and Flag
Human IL23A-3545H Recombinant Human IL23A Protein (Arg20-Pro189), His tagged E.coli His
Human IL23A-4846H Recombinant Human IL23A Protein (Arg20-Pro189), C-His tagged Mammalian cells C-His
Human IL23A-4845H Recombinant Human IL23A Protein (Arg20-Pro189), C-Fc tagged Mammalian cells C-Fc
Human IL23A-179H Recombinant Active Human IL23A Protein, His-tagged(N-ter) E.coli His(N-ter)
Human IL23A-244H Active Recombinant Human IL23A Protein (Arg20-Pro189), N-His tagged, Animal-free, Carrier-free E.coli N-His
Human IL23A-600HFL Active Recombinant Full Length Human IL23A Protein, C-Flag-tagged Mammalian cells Flag
Mouse Il23a-651M Active Recombinant Mouse Interleukin 23, Alpha Subunit P19 Spodoptera Frugiperda N/A
Mouse IL23A-159M Recombinant Mouse Il23a & Il12b, His tagged Human Cell His
Mouse IL23A-8156M Recombinant Mouse IL23A Protein Mammalian Cell His
Mouse Il23a-2461M Recombinant Mouse Il23a protein, His-tagged E.coli His
Mouse Il23a-2304M Recombinant Mouse Il23a Protein, His-tagged HEK293F N-His
Mouse IL23A-4508M-B Recombinant Mouse IL23A Protein Pre-coupled Magnetic Beads HEK293
Mouse Il23a-1927M Recombinant Mouse Il23a Protein Insect Cell N/A
Mouse Il23a-1784M Recombinant Mouse Il23a protein, His & SUMO-tagged E.coli His/SUMO
Mouse Il23a-2305M Recombinant Mouse Il23a Protein, His-tagged E.coli N-His
Mouse Il23a-6745M Recombinant Mouse Il23a Protein (Val22-Ala196, Met23-Ser335) Mammalian cells Tag Free
Mouse Il23a-3515M Active Recombinant Mouse Il23a Protein Sf9
Mouse IL23A-4508M Recombinant Mouse IL23A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il23a-3516M Recombinant Mouse Il23a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Il12b&Il23a-747R Active Recombinant Rat Il12b&Il23a Sf21 Insect Cell N/A
Rat Il23a&Il12b-556R Recombinant Rat Il23a&Il12b Human Cell N/A
Rat IL23A-3041R Recombinant Rat IL23A Protein Mammalian Cell His
Rat IL23a-3326R Recombinant Rat IL23a protein, His-tagged E.coli His
Rat IL23A-2696R Recombinant Rat IL23A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL23a-3330R Recombinant Rat IL23a protein, His-SUMO-tagged E.coli His-SUMO
Rat IL23A-2696R-B Recombinant Rat IL23A Protein Pre-coupled Magnetic Beads HEK293
Rat IL23a-3335R Recombinant Rat IL23a protein, His-GST-tagged E.coli His/GST
Rat IL23a-3322R Recombinant Rat IL23a protein, His-GST-tagged E.coli His/GST
Bovine IL23A-239B Active Recombinant Bovine Interleukin 23, Alpha Subunit P19 Yeast N/A
Cynomolgus Monkey IL23A-617C Recombinant Cynomolgus IL23A Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IL23A-364C-B Recombinant Cynomolgus Monkey IL23A Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL23A-364C Recombinant Cynomolgus Monkey IL23A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Guinea pig IL23A-4326G Recombinant Guinea pig IL23A protein, His&Myc-tagged E.coli His&Myc
Marmoset IL23A-162M Recombinant Marmoset IL23A & IL12B, His tagged Human Cell Fc
Rhesus Macaque IL23A-2246R Recombinant Rhesus monkey IL23A Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL23A-2067R-B Recombinant Rhesus Macaque IL23A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL23A-2067R Recombinant Rhesus Macaque IL23A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig IL23A-1327P Recombinant Pig IL23A Full Length Transmembrane protein, His&Myc-tagged In vitro E. coli expression system His&Myc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL23A Related Articles
  • IL23A Related Research Area

IL23A involved in several pathways and played different roles in them. We selected most pathways IL23A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCL5;BMPR1A;FLT4;CD40;CXCL3;CCL13;IFNAR1;LIFR;PDGFRA
Jak-STAT signaling pathwayCSH2;IFNE;RAF1A;Il4ra;IFNA3;IL2RGB;SOCS6;IFNW1;JAK2A
PertussisTICAM2;SERPING1;ITGB2L;MAPK10;MAPK12;MAPK9;CXCL5;C1QC;C4BPB
TuberculosisIFNA2;HLA-DPB1;HLA-DRB5;H2-AB1;MYD88;Il23a; Il12b;ARHGEF12;RIPK2;HLA-DMB
Inflammatory bowel disease (IBD)IFNGR2;RORC;HLA-DMA;TGFB2;SMAD2;IL22;H2-AB1;TLR4;HLA-DQB1
Rheumatoid arthritisATP6V0D2;ATP6V1H;CTLA4;CXCL6;H2-AB1;IL18;CCL3L1;ITGAL;HLA-DPB1

IL23A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IL23A itself. We selected most functions IL23A had, and list some proteins which have the same functions with IL23A. You can find most of the proteins on our site.

Function Related Protein

IL23A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23A.

Masaki, K; Suzuki, Y; et al. Dual Role of Interleukin-23 in Epicutaneously-Sensitized Asthma in Mice. ALLERGOLOGY INTERNATIONAL 63:13-22(2014).
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is this bioactive cyno IL-23 heterodimer (p19/p40) or just the cyno IL-23p19 subunit? 02/01/2023

Please inquiry our product manager with specific product.

Are there any FDA-approved drugs targeting IL23A? 12/22/2021

Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.

Is IL23A involved in the regulation of adaptive or innate immunity? 08/23/2018

IL23A primarily plays a role in regulating the adaptive immune response.

How is IL23A linked to the pathogenesis of ankylosing spondylitis? 01/25/2018

IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.

How does IL23A contribute to rheumatoid arthritis? 09/01/2017

In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.

How is IL23A involved in inflammatory bowel diseases like Crohn's disease? 07/03/2016

IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.

Customer Reviews (3)

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Reviews
04/18/2020

    Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.

    12/02/2016

      Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

      02/25/2016

        Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.

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