Recombinant Human IL2RB Protein (Ala27-Asp239), C-6×His-tagged

• Cat.No.: IL2RB-247H
• Product Overview: Recombinant Human IL2RB Protein (Ala27-Asp239) with C-6×His tag was expressed in HEK293.

Specification

• Description: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
• Source: HEK293
• Species: Human
• Tag: C-6×His
• Form: Lyophilized
• Molecular Mass: 25.4 kDa
• Protein Length: Ala27-Asp239
• Purity: > 95% as determined by SDS-PAGE and Coomassie blue staining.
• Storage: Store at -80 centigrade for 12 months (Avoid repeated freezing and thawing)
• Storage Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 61 % trehalose is added as protectants before lyophilization.

Gene Information

• Gene Name: IL2RB interleukin 2 receptor, beta [ Homo sapiens (human) ]
• Official Symbol: IL2RB
• Synonyms: IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75
• Gene ID: 3560
• mRNA Refseq: NM_00878
• Protein Refseq: NP_00869
• MIM: 146710
• UniProt ID: P14784