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Recombinant Canine IL2RB, Fc-tagged

Cat.No. : IL2RB-176C
Product Overview : A DNA sequence encoding the extracellular domain of the canine IL2RB (XP_003431552.1) (Met1-Pro244) was expressed with the Fc region of human IgG1 at the C-terminus.
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  • Gene Information
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Source : Human Cells
Species : Canine
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant canine IL2RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 461 amino acids and has a predicted molecular mass of 52.3 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
Protein length : Met1-Pro244
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : IL2RB interleukin 2 receptor, beta [ Canis lupus familiaris ]
Official Symbol : IL2RB
Synonyms : IL2RB; interleukin 2 receptor, beta; interleukin-2 receptor subunit beta; IL 2/15 receptor beta chain;
Gene ID : 403439
mRNA Refseq : NM_001197068
Pathway : Cytokine Signaling in Immune system, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin receptor SHC signaling, organism-specific biosystem; Interleukin-2 signaling, organism-specific biosystem; Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is IL2RB and what are its clinical applications? 09/18/2022

It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

What is the effect of IL2RB in the treatment of tumor? 05/27/2022

There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

What is the therapeutic mechanism of IL2RB in clinical use? 12/13/2021

This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

What diseases is IL2RB associated with? 06/07/2021

IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

Can IL2RB be an alternative to traditional treatment? 04/10/2020

IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

Does IL2RB have side effects? 06/22/2019

IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.

Customer Reviews (3)

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Reviews
09/07/2021

    Immunogenicity is very weak and does not cause an immune response.

    12/27/2019

      Detection method is very sensitive and can detect trace amounts of protein.

      08/15/2019

        Preparation process is very simple and can be easily prepared.

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