Recombinant Canine IL2RB, Fc-tagged
Cat.No. : | IL2RB-176C |
Product Overview : | A DNA sequence encoding the extracellular domain of the canine IL2RB (XP_003431552.1) (Met1-Pro244) was expressed with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
- Related Products
Source : | Human Cells |
Species : | Canine |
Tag : | Fc |
Form : | Lyophilized from sterile PBS, pH7.4. |
Molecular Mass : | The recombinant canine IL2RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 461 amino acids and has a predicted molecular mass of 52.3 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions. |
Protein length : | Met1-Pro244 |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | IL2RB interleukin 2 receptor, beta [ Canis lupus familiaris ] |
Official Symbol : | IL2RB |
Synonyms : | IL2RB; interleukin 2 receptor, beta; interleukin-2 receptor subunit beta; IL 2/15 receptor beta chain; |
Gene ID : | 403439 |
mRNA Refseq : | NM_001197068 |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin receptor SHC signaling, organism-specific biosystem; Interleukin-2 signaling, organism-specific biosystem; Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem; Signaling by Interleukins, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
IL2RB-2699R | Recombinant Rat IL2RB Protein, His (Fc)-Avi-tagged | +Inquiry |
IL2RB-453C | Recombinant Canine IL2RB Protein, His-tagged | +Inquiry |
IL2RB-2069R | Recombinant Rhesus Macaque IL2RB Protein, His (Fc)-Avi-tagged | +Inquiry |
IL2RB-783H | Active Recombinant Human IL2RB protein(Met1-Asp239) | +Inquiry |
IL2RB-454R | Active Recombinant Rhesus IL2RB protein(Met1-Asp239), hFc-tagged | +Inquiry |
◆ Lysates | ||
IL2RB-741CCL | Recombinant Canine IL2RB cell lysate | +Inquiry |
IL2RB-744MCL | Recombinant Mouse IL2RB cell lysate | +Inquiry |
IL2RB-2906HCL | Recombinant Human IL2RB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.
There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.
This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.
IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).
IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.
IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.
Customer Reviews (3)
Write a reviewImmunogenicity is very weak and does not cause an immune response.
Detection method is very sensitive and can detect trace amounts of protein.
Preparation process is very simple and can be easily prepared.
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