IL2RB Protein


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Official Full Name IL2RB interleukin 2 receptor, beta
Background CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
Synonyms IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75;
    • Species :
    • Canine
    • Cynomolgus
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • Human Cell
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • C-6His-Avi
    • Fc
    • hIgG1
    • hIgG4
    • His
    • His/Avi
    • His\Avi
    • His-Avi
    • human
    • IgG1
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL2RB-624H Active Recombinant Human IL2RB Sf21 Insect Cell N/A Inquiry
    Human IL2RB-051H Active Recombinant Human IL2RB protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Inquiry
    Human IL2RB-1643H Recombinant Human Interleukin 2 Receptor, Beta Sf21 Insect Cell N/A Inquiry
    Human IL2RB-29776TH Recombinant Human IL2RB, Fc-tagged Fc Inquiry
    Human IL2RB-700H Recombinant Human IL2RB, MIgG2a Fc-tagged CHO Fc Inquiry
    Human IL2RB-701H Recombinant Human IL2RB, HIgG1 Fc-tagged CHO Fc Inquiry
    Human IL2RB-782H Recombinant Human IL2RB protein, Fc-tagged HEK293 human/IgG1/Fc Inquiry
    Human IL2RB-783H Recombinant Human IL2RB, None tagged Human Cell N/A Inquiry
    Human IL2RB-785H Recombinant Human IL2RB Protein, His-tagged HEK293 His Inquiry
    Mouse IL2RB-1257M Recombinant Mouse IL2RB Protein, His-tagged Yeast His Inquiry
    Mouse Il2rb-271R Recombinant Mouse Il2rb Protein, His-tagged E.coli His Inquiry
    Mouse Il2rb-483M Recombinant Mouse Il2rb, His-tagged Human Cell His Inquiry
    Rat Il2rb-22R Recombinant Rat Il2rb protein, His-tagged E.coli His Inquiry
    Rat IL2RB-3044R Recombinant Rat IL2RB Protein Mammalian Cell His Inquiry
    Cynomolgus IL2RB-619C Recombinant Cynomolgus IL2RB Protein, His-tagged HEK293 His
    Rhesus monkey IL2RB-1553R Recombinant Rhesus Monkey IL2RB Protein HEK293 N/A Inquiry
    Rhesus monkey IL2RB-1554R Recombinant Rhesus Monkey IL2RB Protein, hIgG1-tagged HEK293 hIgG1 Inquiry
    Rhesus monkey IL2RB-1555R Recombinant Rhesus Monkey IL2RB Protein, hIgG4-tagged HEK293 hIgG4 Inquiry
    Rhesus Macaque IL2RB-2248R Recombinant Rhesus monkey IL2RB Protein, His-tagged Mammalian Cell His Inquiry
    Canine IL2RB-176C Recombinant Canine IL2RB, Fc-tagged Human Cell Fc Inquiry
    Zebrafish IL2RB-6828Z Recombinant Zebrafish IL2RB Mammalian Cell His Inquiry
    Human IL2RB-2906HCL Recombinant Human IL2RB cell lysate Human Cell N/A Inquiry
    Mouse IL2RB-744MCL Recombinant Mouse IL2RB cell lysate Human Cell N/A Inquiry
    Canine IL2RB-741CCL Recombinant Canine IL2RB cell lysate Human Cell N/A Inquiry
    Human IL2RB-201H Recombinant Human IL2RB Protein, His\Avi-tagged Human Cell His\Avi Inquiry
    Human IL2RB-2310H Recombinant Human IL2RB Protein, His-tagged E.coli N-His Inquiry
    Human IL2RB-29H Recombinant Human IL2RB Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Inquiry
    Mouse Il2rb-3101M Recombinant Mouse Il2rb protein, His-tagged E.coli His Inquiry
    Mouse Il2rb-484M Recombinant Mouse Il2rb(Ala27-Glu240) Protein, C-Fc-tagged HEK293 Fc Inquiry
    Human IL2RB-5757HF Recombinant Full Length Human IL2RB Protein In Vitro Cell Free System Inquiry
    Rattus norvegicus (Rat) RFL6695RF Recombinant Full Length Rat Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His Inquiry
    Homo sapiens (Human) RFL8063HF Recombinant Full Length Human Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His Inquiry
    Human IL2RB-420H Recombinant Human IL2RB Protein (Met1-Asp239), His-tagged Insect Cell His Inquiry
    Human IL2RB-5195H Recombinant Human IL2RB Protein Wheat Germ N/A Inquiry
    Human IL2RB-5196H Recombinant Human IL2RB Protein HEK293 N/A Inquiry
    Human IL2RB-869H Recombinant Human IL2RB protein, His-Avi-tagged HEK293 His-Avi Inquiry
    Human IL2RB-869HB Recombinant Human IL2RB protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Inquiry
    Rat IL2RB-951R Recombinant Rat IL2RB Protein (Met1-Glu239), His-tagged HEK293 His Inquiry
    Rhesus IL2RB-1007R Recombinant Rhesus IL2RB Protein (Met1-Asp239), His-tagged HEK293 His Inquiry
    Rhesus IL2RB-454R Recombinant Rhesus IL2RB Protein, Fc-tagged HEK293 Fc Inquiry
    Canine IL2RB-453C Recombinant Canine IL2RB Protein, His-tagged HEK293 His Inquiry

    IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction PDGFRA; ACVR1; PRLR; IL1R1; IFNE; IL18; CXCR5; CCL18; BMPR1AB; CXCL10
    Endocytosis ARFGEF2; SH3GLB1B; AP2M1A; SNX12; RAB5B; CAV2; KIF5B; LDLRAP1A; ACAP1; ZFYVE27
    PIK-Akt signaling pathway IL3; CREB3L1; ITGB4; PDGFC; MTOR; PCK2; MAP2K1; PPP2R2B; TP53; IFNA12
    Jak-STAT signaling pathway CRFB4; OSMR; EPO; IFNA2; SOS1; EP300; IL22RA1; STAT1; PRLRA; TP-1
    Measles CCNE2; RELA; STAT5A; OAS3; cgr2b; AKT1; GSK3B; TNFRSF10C; RAB9B; RCHY1
    Transcriptional misregulation in cancer BCL2A1A; MLLT3; FOXO1; BCL2A1; HIST1H3A; MLL1; PRCC; PAX5; ZBTB17; TSPAN7

    IL2RB has several biochemical functions, for example, interleukin-2 binding, interleukin-2 receptor activity, contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-2 binding IL2RG; IL2RB; IL2RA
    interleukin-2 receptor activity IL2RB; IL2RA
    contributes_to interleukin-2 receptor activity IL2RB; IL2RG
    protein binding MRAP2; RUNX1T1; TBC1D2; LTBP1; EEF1D; MIEN1; NCOA3; DNAJC11; RAB11FIP2; CRKL

    IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.

    IL15; IL15RA; ubiA; STAT5A; STAT5B; SHB

    Ovsyannikova, IG; Haralambieva, IH; et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. GENE 510:59-65(2012).
    Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).

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