IL2RB
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Official Full Name
IL2RB interleukin 2 receptor, beta -
Overview
CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. -
Synonyms
IL2RB;interleukin 2 receptor, beta;IL15RB, interleukin 15 receptor, beta;interleukin-2 receptor subunit beta;CD122;p75;IL-2RB;CD122 antigen;IL-2R subunit beta;IL-2 receptor subunit beta;interleukin 15 receptor, beta;high affinity IL-2 receptor beta subunit;high affinity IL-2 receptor subunit beta;IL15RB;P70-75
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- Canine
- Rat
- Zebrafish
- Pig
- HEK293
- Sf21 Cells
- Yeast
- Human Cells
- Mammalian Cells
- E.coli
- CHO
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- Avi
- Fc
- hIgG4
- mFc
Involved Pathway
IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction,Endocytosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | Aff1,PER2,PAX3,ETV6,Bcl2a1b,RUNX2,HIST2H3C1,WT1,TSPAN7,NFKB1 |
| Endocytosis | GBF1,RAB11A,ARRB2A,DNM2,ARPC2,CHMP6B,FOLR1,VPS4A,TGFB2,VPS37C |
| Measles | IRF3,CD3E,IFNA16,TNFRSF10A,SLAMF1,OAS1B,HSPA2,CCND2,OAS1A,HSPA1B |
| PIK-Akt signaling pathway | PTEN,FGFR4,ANGPT1,IFNA6,FGF6,PDGFRA,PPP2CA,ITGB6,RPTOR,IGF1R |
| Jak-STAT signaling pathway | CNTFR,IL22,GM2002,IL7,HRAS,IL-15RA,IL13RA1,PTPN6,IL6R,PRLR |
| Cytokine-cytokine receptor interaction | CRLF2,GH2,TGFB1A,M17,GM1987,CCL5,TGFBR2,IFNA2,INHBB,IL1RAP |
| HTLV-I infection | TLN1,CD40,TBP,VAC14,HLA-DRB1,NFATC1,HLA-DPA1,POLD4,RB1,STAT5B |
Protein Function
IL2RB has several biochemical functions, for example, interleukin-2 binding,interleukin-2 receptor activity,contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MLF1IP,INPP5A,HSPA4,PENK,ZFP57,NCK1,TLDC2,AMFR,CUBN,COL6A5 |
| interleukin-2 binding | IL2RA,IL2RG |
| interleukin-2 receptor activity | IL2RA |
| contributes_to interleukin-2 receptor activity | IL2RG |
Interacting Protein
IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.
IL15;IL15RA;ubiA;STAT5A;STAT5B;SHB
IL2RB Related Signal Pathway
Resources
Research Area
NeuroinflammationNatural Killer Cells (NK Cells) Markers
Natural Killer (NK) Cell CD Antigen
Multiple Sclerosis and Myelin Related Molecules
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Natural Killer T (NKT) Cells
CD Antigen (Helper T Cells)
CD Antigen (Regulatory T Cells)
T Follicular Helper (Tfh) Cells
Common gamma Chain Family Receptors
Related Services
Related Products
References
- Ovsyannikova, IG; Haralambieva, IH; et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. GENE 510:59-65(2012).
- Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
