IL2RB

  • Official Full Name

    IL2RB interleukin 2 receptor, beta

  • Background

    CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation.
  • Synonyms

    IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75;
    • Type:
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Canine
    • Cynomolgus
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Pig
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • Human Cell
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • C
    • 6×His
    • 6His
    • Avi
    • His
    • Fc
    • hIgG1
    • hIgG4
    • His (Fc)
    • Twin
    • Strep
    • His\Avi
    • human|IgG1|Fc
    • mFc
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL2RB-741CCL Recombinant Canine IL2RB cell lysate Human Cell N/A
    Canine IL2RB-453C Recombinant Canine IL2RB Protein, His-tagged HEK293 His
    Canine IL2RB-176C Recombinant Canine IL2RB, Fc-tagged Human Cell Fc
    Canine IL2RB-0282C Recombinant Canine IL2RB protein, His-tagged HEK293 His
    Cynomolgus IL2RB-0281C Recombinant Cynomolgus IL2RB protein, His-tagged HEK293 His
    Cynomolgus IL2RB-619C Recombinant Cynomolgus IL2RB Protein, His-tagged HEK293 His
    Homo sapiens (Human) RFL8063HF Recombinant Full Length Human Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His
    Human IL2RB-5196H Recombinant Human IL2RB Protein HEK293 N/A
    Human IL2RB-321H Recombinant Human IL2RB Protein, His-tagged HEK293 His
    Human IL2RB-0284H Recombinant Human IL2RB protein, Fc-tagged HEK293 Fc
    Human IL2RB-201H Recombinant Human IL2RB Protein, His\Avi-tagged Human Cell His\Avi
    Human IL2RB-5757HF Recombinant Full Length Human IL2RB Protein In Vitro Cell Free System
    Human IL2RB-1979H Recombinant Human IL2RB protein, mFc-tagged HEK293 mFc
    Human IL2RB-247H Recombinant Human IL2RB Protein (Ala27-Asp239), C-6×His-tagged HEK293 C-6×His
    Human IL2RB-785H Recombinant Human IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep
    Human IL2RB-2906HCL Recombinant Human IL2RB cell lysate Human Cell N/A
    Human IL2RB-947H Recombinant Human IL2RB protein, His-tagged HEK293 His
    Human IL2RB-1643H Recombinant Human Interleukin 2 Receptor, Beta Sf21 Insect Cell N/A
    Human IL2RB-420H Recombinant Human IL2RB Protein (Met1-Asp239), His-tagged Insect Cell His
    Human IL2RB-782H Recombinant Human IL2RB protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL2RB-624H Active Recombinant Human IL2RB Sf21 Insect Cell N/A
    Human IL2RB-2310H Recombinant Human IL2RB Protein, His-tagged E.coli N-His
    Human IL2RB-869HB Recombinant Human IL2RB protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL2RB-29776TH Recombinant Human IL2RB, Fc-tagged Fc
    Human IL2RB-783H Recombinant Human IL2RB, None tagged Human Cell N/A
    Human IL2RB-29H Recombinant Human IL2RB Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi
    Human IL2RB-869H Recombinant Human IL2RB protein, His-Avi-tagged HEK293 His-Avi
    Human IL2RB-701H Recombinant Human IL2RB, HIgG1 Fc-tagged CHO Fc
    Human IL2RB-5195H Recombinant Human IL2RB Protein Wheat Germ N/A
    Human IL2RB-700H Recombinant Human IL2RB, MIgG2a Fc-tagged CHO Fc
    Human IL2RB-051H Active Recombinant Human IL2RB protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi
    Human IL2RB-7125H Recombinant Human IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep
    Human IL2RB-066H Recombinant Human IL2RB Protein, C-His-tagged E.coli C-His
    Mouse IL2RB-1257M Recombinant Mouse IL2RB Protein, His-tagged Yeast His
    Mouse Il2rb-484M Recombinant Mouse Il2rb(Ala27-Glu240) Protein, C-Fc-tagged HEK293 Fc
    Mouse Il2rb-483M Recombinant Mouse Il2rb, His-tagged Human Cell His
    Mouse IL2RB-744MCL Recombinant Mouse IL2RB cell lysate Human Cell N/A
    Mouse Il2rb-3101M Recombinant Mouse Il2rb protein, His-tagged E.coli His
    Mouse Il2rb-271R Recombinant Mouse Il2rb Protein, His-tagged E.coli His
    Mouse IL2RB-0283M Recombinant Mouse IL2RB protein, His-tagged HEK293 His
    Pig IL2Rb-3328P Recombinant Pig IL2Rb protein, His-tagged E.coli His
    Rat IL2RB-951R Recombinant Rat IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep
    Rat IL2RB-2699R-B Recombinant Rat IL2RB Protein Pre-coupled Magnetic Beads HEK293
    Rat IL2RB-2699R Recombinant Rat IL2RB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat IL2RB-3044R Recombinant Rat IL2RB Protein Mammalian Cell His
    Rat Il2rb-22R Recombinant Rat Il2rb protein, His-tagged E.coli His
    Rat IL2RB-9511R Recombinant Rat IL2RB protein, His&Twin-Strep-tagged HEK293 His&Twin-Strep
    Rattus norvegicus (Rat) RFL6695RF Recombinant Full Length Rat Interleukin-2 Receptor Subunit Beta(Il2Rb) Protein, His-Tagged E.coli expression system His
    Rhesus IL2RB-619R Active Recombinant Rhesus IL2RB Protein, His-tagged HEK293 His
    Rhesus IL2RB-454R Recombinant Rhesus IL2RB Protein, Fc-tagged HEK293 Fc
    Rhesus IL2RB-1007R Recombinant Rhesus IL2RB Protein (Met1-Asp239), His-tagged HEK293 His
    Rhesus Macaque IL2RB-2069R-B Recombinant Rhesus Macaque IL2RB Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL2RB-2248R Recombinant Rhesus monkey IL2RB Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL2RB-2069R Recombinant Rhesus Macaque IL2RB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus monkey IL2RB-1554R Recombinant Rhesus Monkey IL2RB Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey IL2RB-1555R Recombinant Rhesus Monkey IL2RB Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus monkey IL2RB-1553R Recombinant Rhesus Monkey IL2RB Protein HEK293 N/A
    Zebrafish IL2RB-6828Z Recombinant Zebrafish IL2RB Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL2RB Related Articles
    • IL2RB Related Gene Family
    • IL2RB Related Research Area
    • IL2RB Related Signal Pathway

    IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionBMP2;Flt3l;IL20;CXCR4;CRFB16;IFNGR1;PRL2;CCL6;TNFRSF11A
    EndocytosisARPC5LA;VPS26B;RAB11FIP3;EHD3;SH3GLB2B;KDR;CHMP2B;ARPC3;PIP5K1AB
    PIK-Akt signaling pathwayGNB1;COL24A1;TNXB;RPS6KB1;TCL1B4;OSM;GSK3B;PDGFC;NOS3
    Jak-STAT signaling pathwayIFNA13;IL10RA;BCL2A;IL20RA;GRB2B;PIK3R5;AOX3;Il6ra;STAT3
    MeaslesHSPA1A;CD3D;FAS;IFNA12;TNFRSF10B;IL4;PIK3CA;IL12A;FASLG
    HTLV-I infectionNFATC4;EGR2;WNT2B;MYBL1;HLA-DRB4;CRTC1;HLA-F;FZD10;IL1R1
    Transcriptional misregulation in cancerCD14;IL3;BMP2K;TAF15;MAF;CEBPE;RELA;MLLT1;ATM

    IL2RB has several biochemical functions, for example, interleukin-2 binding, interleukin-2 receptor activity, contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-2 bindingIL2RB;IL2RA;IL2RG
    interleukin-2 receptor activityIL2RA;IL2RB
    contributes_to interleukin-2 receptor activityIL2RG;IL2RB
    protein bindingAP5Z1;UBE2W;PPP1R2P9;P2RX4;LNX1;CD1B;AKAP6;TRIM69;POU4F1

    IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.

    IL15; IL15RA; ubiA; STAT5A; STAT5B; SHB

    Ovsyannikova, IG; Haralambieva, IH; et al. Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination. GENE 510:59-65(2012).
    Kennedy, RB; Ovsyannikova, IG; et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. VACCINE 30:2159-2167(2012).
    IL
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What is IL2RB and what are its clinical applications? 09/18/2022

    It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

    What is the effect of IL2RB in the treatment of tumor? 05/27/2022

    There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

    What is the therapeutic mechanism of IL2RB in clinical use? 12/13/2021

    This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

    What diseases is IL2RB associated with? 06/07/2021

    IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

    Can IL2RB be an alternative to traditional treatment? 04/10/2020

    IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

    Does IL2RB have side effects? 06/22/2019

    IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.

    Customer Reviews (3)

    Write a review
    Reviews
    09/07/2021

      Activity of IL2RB in vivo, cell experiments and animal models can be used to detect its activity in regulating immune response and cell proliferation. -

      12/27/2019

        The binding ability of IL2RB to ligands (such as IL-2) and its effect on signal transduction were verified by cell experiments. -

        08/15/2019

          To evaluate the structural and functional integrity of IL2RB, the protein structure and folding state can be studied by crystallography, CD spectroscopy and other techniques. -

          Ask a Question for All IL2RB Products

          Required fields are marked with *

          My Review for All IL2RB Products

          Required fields are marked with *

          logo

          Stay Updated on the
          Latest Bioscience Trends

          Copyright © 2023 Creative BioMart. All Rights Reserved.

          Terms and Conditions        Privacy Policy