IL2RB
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Official Full Name
IL2RB interleukin 2 receptor, beta
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Background
CD122 is a 70-75 kD IL-2 receptor beta chain also known as IL-2Rbeta, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rbeta chain can combine with either the common gamma subunit (gammac, CD132) alone or with the gammac subunit and the IL-2Ralpha subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. -
Synonyms
IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL2RB Related Articles
- IL2RB Related Gene Family
- IL2RB Related Research Area
- IL2RB Related Signal Pathway
IL2RB involved in several pathways and played different roles in them. We selected most pathways IL2RB participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMP2;Flt3l;IL20;CXCR4;CRFB16;IFNGR1;PRL2;CCL6;TNFRSF11A |
| Endocytosis | ARPC5LA;VPS26B;RAB11FIP3;EHD3;SH3GLB2B;KDR;CHMP2B;ARPC3;PIP5K1AB |
| PIK-Akt signaling pathway | GNB1;COL24A1;TNXB;RPS6KB1;TCL1B4;OSM;GSK3B;PDGFC;NOS3 |
| Jak-STAT signaling pathway | IFNA13;IL10RA;BCL2A;IL20RA;GRB2B;PIK3R5;AOX3;Il6ra;STAT3 |
| Measles | HSPA1A;CD3D;FAS;IFNA12;TNFRSF10B;IL4;PIK3CA;IL12A;FASLG |
| HTLV-I infection | NFATC4;EGR2;WNT2B;MYBL1;HLA-DRB4;CRTC1;HLA-F;FZD10;IL1R1 |
| Transcriptional misregulation in cancer | CD14;IL3;BMP2K;TAF15;MAF;CEBPE;RELA;MLLT1;ATM |
IL2RB has several biochemical functions, for example, interleukin-2 binding, interleukin-2 receptor activity, contributes_to interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RB itself. We selected most functions IL2RB had, and list some proteins which have the same functions with IL2RB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-2 binding | IL2RB;IL2RA;IL2RG |
| interleukin-2 receptor activity | IL2RA;IL2RB |
| contributes_to interleukin-2 receptor activity | IL2RG;IL2RB |
| protein binding | AP5Z1;UBE2W;PPP1R2P9;P2RX4;LNX1;CD1B;AKAP6;TRIM69;POU4F1 |
IL2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RB.
IL15; IL15RA; ubiA; STAT5A; STAT5B; SHB
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.
There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.
This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.
IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).
IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.
IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.
Customer Reviews (3)
Write a reviewActivity of IL2RB in vivo, cell experiments and animal models can be used to detect its activity in regulating immune response and cell proliferation. -
The binding ability of IL2RB to ligands (such as IL-2) and its effect on signal transduction were verified by cell experiments. -
To evaluate the structural and functional integrity of IL2RB, the protein structure and folding state can be studied by crystallography, CD spectroscopy and other techniques. -
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