Recombinant Human IL3RA Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: IL3RA-6326H
• Product Overview: IL3RA MS Standard C13 and N15-labeled recombinant protein (NP_002174) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 43.33 kDa
• AA Sequence: MVLLWLTLLLIALPCLLQTKEDPNP PITNLRMKAKAQQLTWDLNRNVTDI ECVKDADYSMPAVNNSYCQFGAISL CEVTNYTVRVANPPFSTWILFPENS GKPWAGAENLTCWIHDVDFLSCSWA VGPGAPADVQYDLYLNVANRRQQYE CLHYKTDAQGTRIGCRFDDISRLSS GSQSSHILVRGRSAAFGIPCTDKFV VFSQIEILTPPNMTAKCNKTHSFMH WKMRSHFNRKFRYELQIQKRMQPVI TEQVRDRTSFQLLNPGTYTVQIRAR ERVYEFLSAWSTPQRFECDQEEGAN TRAWRTSLLIALGTLLALVCVFVIC RRYLVMQRLFPRIPHMKDPIGDSFQ NDKLVVWEAGKAGLEECLVTEVQVV QKTTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: IL3RA interleukin 3 receptor subunit alpha [ Homo sapiens (human) ]
• Official Symbol: IL3RA
• Synonyms: IL3RA; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; CD123; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform; IL3R; IL3RX; IL3RY; IL3RAY; hIL-3Ra; MGC34174
• Gene ID: 3563
• mRNA Refseq: NM_002183
• Protein Refseq: NP_002174
• MIM: 308385
• UniProt ID: P26951