IL3RA
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Official Full Name
interleukin 3 receptor, alpha (low affinity)
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Background
CD123 is a 70 kD alpha chain subunit of the IL-3 receptor (IL-3R alpha). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind I -
Synonyms
IL3RA; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; CD123; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform; IL3R; IL3RX; IL3RY; IL3RAY; hIL-3Ra; MGC34174;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL3RA Related Gene Family
- IL3RA Related Research Area
- IL3RA Related Signal Pathway
IL3RA involved in several pathways and played different roles in them. We selected most pathways IL3RA participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR1;LEPB;TNFRSF8;CCL14;MET;INHBC;IL25;IFNA2;KDR |
| PIK-Akt signaling pathway | PTEN;PKN3;ITGA8;GNB4;VTN;FGF1;IFNA16;ITGA4;Il6ra |
| Apoptosis | PRKACAA;RNF8;BIRC3;CASP6L1;CLSPN;RIPK1L;FASLG;GAS2;PRKAR1A |
| Jak-STAT signaling pathway | CCND1;IL2RA;PTPN11B;IFNPHI1;STAT3;CSH;IFNA21;CTF1;IFNA10 |
| Hematopoietic cell lineage | GYPA;Kitl;CD1A;HLA-DRA;CD3G;CD22;CD44;FCER2;IL3RA |
IL3RA has several biochemical functions, for example, interleukin-3 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3RA itself. We selected most functions IL3RA had, and list some proteins which have the same functions with IL3RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-3 receptor activity |
IL3RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3RA.
FYN; NCK1; PLCG1; GRB2; CDK1; CDC25A; GNA12; NR0B2; LNX1; FOXP1; SGK2; SAE1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.
Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.
Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.
Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.
The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.
Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.
Customer Reviews (3)
Write a reviewIt is highly specific, that is, it binds only to its receptor IL-3R, and it has high potential in fighting disease and drug discovery -
Depending on the need, different IL-3Rα variants or mutants can be customized through techniques such as genetic modification to achieve the production of their specific properties. -
IL-3rα, by binding to its receptor, plays an important role in regulating biological processes such as cell proliferation and differentiation, and its biological activity needs to be guaranteed and can be detected by biological identification and other methods. -
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