Recombinant Human IL5 protein
Cat.No. : | IL5-144H |
Product Overview : | Recombinant Human IL5 was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Interleukin 5 (IL5) is a specific hematopoietic growth factor that is responsible for the growth and differentiation of eosinophils. IL5 promotes the growth of immature hematopoietic progenitor cells BFU-E while it causes differentiation of CFU-E the proliferation of which is inhibited by IL5. B cells can be made responsive to IL5 by treatment with suboptimal doses of IL1. Interleukin 5 also promotes the generation of cytotoxic T cells from thymocytes. In thymocytes IL5 induces the expression of high affinity IL2 receptors. Human and mouse IL5 is cross-species reactive. Recombinant Human IL5 is a 26.5 kDa disulfide-linked homodimerized protein. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered solution in Tris with NaCl |
Molecular Mass : | 13.0 kDa |
Endotoxin : | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
Purity : | >95% |
Applications : | Cell Assay |
Storage : | The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade - 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
Reconstitution : | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
Gene Name : | IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ] |
Official Symbol : | IL5 |
Synonyms : | IL5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; B cell differentiation factor I; EDF; eosinophil differentiation factor; IL 5; interleukin 5; T cell replacing factor; TRF; T-cell replacing factor; B-cell differentiation factor I; IL-5; |
Gene ID : | 3567 |
mRNA Refseq : | NM_000879 |
Protein Refseq : | NP_000870 |
MIM : | 147850 |
UniProt ID : | P05113 |
Chromosome Location : | 5q23-q31 |
Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; |
Function : | cytokine activity; growth factor activity; interleukin-5 receptor binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
IL5-456C | Active Recombinant Canine IL5 Protein, His-tagged | +Inquiry |
IL5-2177C | Active Recombinant Canine IL5 Protein, His-tagged | +Inquiry |
IL5-354I | Active Recombinant Human IL5 Protein (116 aa) | +Inquiry |
Il5-2097M | Recombinant Mouse Il5 Protein | +Inquiry |
IL5-1042H | Recombinant Horse IL5 Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
IL5-456CCL | Recombinant Canine IL5 cell lysate | +Inquiry |
IL5-496MCL | Recombinant Mouse IL5 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionInhibit the creatinine kinase level in the blood of patients with tuberous sclerosis, reduce the inflammatory response, and improve the quality of life of patients.
IL5 can reduce the number of eosinophils in the nasal mucosa of patients with allergic rhinitis, reducing the symptoms of allergic reactions, such as sneezing, runny nose and nasal congestion.
Stimulate the proliferation and differentiation of white blood cells, promote the function of the immune system, and is used to treat diseases such as asthma, allergic rhinitis, nodular sclerosis and some malignant tumors.
Cause mild side effects such as headache, nausea, vomiting, and serious side effects such as allergic reactions if the dose is too large or allergic.
IL5 cannot be administered orally, only by injection or intravenous drip.
IL5 can reduce the number of eosinophils in the lungs of asthma patients, reduce the frequency and severity of asthma attacks, and improve the quality of life of patients.
Customer Reviews (3)
Write a reviewHigh efficacy and safety in clinical treatment.
There are no structural or functional defects.
The stability and activity are maintained well during long-term storage.
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