Recombinant Human IL6R Protein, GST-tagged

Cat.No. : IL6R-5174H
Product Overview : Human IL6R full-length ORF ( NP_000556.1, 1 a.a. - 468 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 77.9 kDa
AA Sequence : MLAVGCALLAALLAAPGAALAPRRC PAQEVARGVLTSLPGDSVTLTCPGV EPEDNATVHWVLRKPAAGSHPSRWA GMGRRLLLRSVQLHDSGNYSCYRAG RPAGTVHLLVDVPPEEPQLSCFRKS PLSNVVCEWGPRSTPSLTTKAVLLV RKFQNSPAEDFQEPCQYSQESQKFS CQLAVPEGDSSFYIVSMCVASSVGS KFSKTQTFQGCGILQPDPPANITVT AVARNPRWLSVTWQDPHSWNSSFYR LRFELRYRAERSKTFTTWMVKDLQH HCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAEN EVSTPMQALTTNKDDDNILFRDSAN ATSLPVQDSSSVPLPTFLVAGGSLA FGTLLCIAIVLRFKKTWKLRALKEG KTSMHPPYSLGQLVPERPRPTPVLV PLISPPVSPSSLGSDNTSSHNRPDA RDPRSPYDISNTDYFFPR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : IL6R interleukin 6 receptor [ Homo sapiens ]
Official Symbol : IL6R
Synonyms : IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; MGC104991;
Gene ID : 3570
mRNA Refseq : NM_000565
Protein Refseq : NP_000556
MIM : 147880
UniProt ID : P08887

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the dose and route of administration of IL6R? 04/30/2022

The dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.

Can recombinant IL6R be used in autoimmune diseases? 04/03/2022

It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

Can recombinant IL6R be used to prevent disease? 09/14/2021

The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.

How the action mechanism of IL6R? 03/20/2021

IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.

Does IL6R have anti-tumor effects? 11/06/2020

Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.

How to evaluate the efficacy of IL6R? 06/29/2019

The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.

Customer Reviews (3)

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Reviews
02/23/2022

    Good compatibility and stability with the surfactant.

    11/23/2020

      Expression level and stability of clones were good.

      02/01/2019

        Remarkable antibacterial activity and bactericidal effect on bacteria.

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