Recombinant Human IL7, His-tagged

Cat.No. : IL7-65H
Product Overview : IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.
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Description : The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.
Source : E.Coli
Species : Human
Tag : His
Form : Sterile Filtered clear solution. Interleukin -7 His is supplied in 1x PBS and 50% glycerol.
Molecular Mass : 21.97 kDa
Purity : Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
Stability : Store at 4ºC if entire vial will be used within 2-4 weeks. Store, frozen at -20ºC for longer periods of time. Please avoid freeze thaw cycles.
Gene Name : IL7 interleukin 7 [ Homo sapiens (human) ]
Official Symbol : IL7
Synonyms : IL7; IL-7; interleukin 7; interleukin-7
Gene ID : 3574
mRNA Refseq : NM_000880
Protein Refseq : NP_000871
MIM : 146660
UniProt ID : P13232
Chromosome Location : 8q12-q13
Pathway : Cytokine Signaling in Immune system; Hematopoietic cell lineage; Interleukin-7 signaling
Function : cytokine activity; growth factor activity; interleukin-7 receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
03/27/2022

    Effective in signal transduction pathway.

    04/17/2021

      IL7 has good absorbability and high bioavailability.

      11/27/2020

        Good stability under different environmental conditions

        Q&As (6)

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        What are the application scenarios of IL7? 10/10/2020

        IL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.

        What is the mechanism of IL7 in the treatment of bladder cancer? 11/25/2019

        IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.

        What is the optimal dose of IL7 in the treatment of leukemia? 07/18/2019

        The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.

        Does the efficacy of IL7 in the treatment of infectious diseases? 04/10/2019

        It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.

        Are there have any efficacy of IL7 in the treatment of specific cancers? 03/31/2019

        Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.

        How to prepare IL7? 03/27/2019

        This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.

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