Recombinant Chicken IL7 Protein, His-tagged

• Cat.No.: IL7-01C
• Product Overview: Recombinant Chicken IL7 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Source: E. coli
• Species: Chicken
• Tag: His
• Form: 50mM Tris, 300mM NaCl, pH 8.0.
• Molecular Mass: 15 kDa
• AA Sequence: MHHHHHHSSCTMGNKTTEIRVKYEN ILSHDIEELVNMSAEYRDRCCKNKR HEHNKVFFCNDTQEIGSLQSMACNM LRFFNKQKINKEFRRKAALVSCGTL QVLQCKCERHKKEKSINASCSQISG KEQQ
• Endotoxin: ＜1EU/ug by LAL
• Purity: > 90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.056 mg/ml
• Publication:
  Clonal anergy of CD117+chB6+ B cell progenitors induced by avian leukosis virus subgroup J is associated with immunological tolerance (2019)

Gene Information

• Gene Name: IL7 interleukin 7 [ Gallus gallus (chicken) ]
• Official Symbol: IL7
• Synonyms: IL-7
• Gene ID: 420193
• mRNA Refseq: NM_001398241
• Protein Refseq: NP_001385170
• UniProt ID: B1GVZ6

Reviews

03/27/2022

Effective in signal transduction pathway.

04/17/2021

IL7 has good absorbability and high bioavailability.

11/27/2020

Good stability under different environmental conditions

Q&As

What are the application scenarios of IL7?

IL7 is widely used in the research and development of immunotherapy protocols, can enhance the body's immune function, for the treatment of cancer, infection, autoimmune diseases and other diseases.

What is the mechanism of IL7 in the treatment of bladder cancer?

IL7 can activate the body's immune system and enhance the immune cells' attack on bladder cancer.

What is the optimal dose of IL7 in the treatment of leukemia?

The dosage of IL7 in the treatment of leukemia needs to be calculated individually according to the specific situation of the patient.

Does the efficacy of IL7 in the treatment of infectious diseases?

It can enhance the function of the body's immune system, and has a certain effect on some infectious diseases.

Are there have any efficacy of IL7 in the treatment of specific cancers?

Recombinant IL7 protein may have some therapeutic effect on specific cancers by activating T cells, but further clinical studies are needed.

How to prepare IL7?

This is obtained by recombinant DNA technology, inserting foreign genes into the host expression system, and then through purification and other steps.