Recombinant Human IL7R Protein, GST-tagged

• Cat.No.: IL7R-5168H
• Product Overview: Human IL7R full-length ORF ( AAH67539.1, 1 a.a. - 459 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 77.9 kDa
• AA Sequence: MTILGTTFGMVFSLLQVVSGESGYA QNGDLEDAELDDYTFSCYSQLEVNG SQHSLTCAFEDPDVNTTNLEFEICG ALVEVKCLNFRKLQEIYFIETKKFL LIGKSNICVKVGEKSLTCKKIDLTT IVKPEAPFDLSVIYREGANDFVVTF NTSHLQKKYVKVLMHDVAYRQEKDE NKWTHVNLSSTKLTLLQRKLQPAAM YEIKVRSIPDHYFKGFWSEWSPSYY FRTPEINNSSGEMDPILLTISILSF FSVALLVILACVLWKKRIKPIVWPS LPDHKKTLEHLCKKPRKNLNVSFNP ESFLDCQIHRVDDIQARDEVEGFLQ DTFPQQLEESEKQRLGGDVQSPNCP SEDVVITPESFGRDSSLTCLAGNVS ACDAPILSSSGSLDCRESGKNGPHV YQDLLLSLGTTNSTLPPPFSLQSGI LTLNPVAQGQPILTSLGSNQEEAYV TMSSFYQNQ
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IL7R interleukin 7 receptor [ Homo sapiens ]
• Official Symbol: IL7R
• Synonyms: IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha
• Gene ID: 3575
• mRNA Refseq: NM_002185
• Protein Refseq: NP_002176
• MIM: 146661
• UniProt ID: P16871