IL7R
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Official Full Name
IL7R interleukin 7 receptor -
Overview
CD127 is a 60-90 kD type I transmembrane glycoprotein, also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development. -
Synonyms
IL7R;interleukin 7 receptor;interleukin-7 receptor subunit alpha;CD127;IL-7RA;CD127 antigen;IL-7R subunit alpha;IL-7 receptor subunit alpha;interleukin 7 receptor alpha chain;interleukin 7 receptor isoform H5-6;ILRA;IL7RA;CDW127;IL-7R-alpha
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Mouse
- Chicken
- Zebrafish
- Callithrix jacchus (White-tufted-ear marmoset)
- Horse
- HEK293
- Human Cells
- CHO
- Mammalian Cells
- E.coli
- Insect Cells
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- His
- Fc
- Avi
- Non
- GST
- T7
- mFc
- Myc
- DDK
- Flag
- SUMO
Involved Pathway
IL7R involved in several pathways and played different roles in them. We selected most pathways IL7R participated on our site, such as Cytokine-cytokine receptor interaction,FoxO signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL7R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | BNIP3,INSR,CCND2,PTENB,SMAD3,IGF1R,GADD45BB,CCNG2,ATG12,CDKN1BA |
| Jak-STAT signaling pathway | IL11RA,IFNPHI1,LIFRA,IFNGR1,CISH,CCND1,CRFB2,IFNA16,IL10RA,CSH |
| Hematopoietic cell lineage | HLA-DRB4,HLA-DRB5,CSF1R,CD7,CD1D,IL11,MME,IL5RA,IL1A,FLT3 |
| Cytokine-cytokine receptor interaction | VEGFA,CCL20B,CXCR7,IL11RA2,IL5RA,CD40LG,CSF1R,Pdgfa&Pdgfb,Ccl21a,TNFSF12 |
| PIK-Akt signaling pathway | GNG4,ITGA9,KITLG,KRAS,RBL2,ITGA8,FGF2,KIT,LPAR5,LAMA1 |
| Primary i | IL2RG,TAP1,TNFRSF13B,AIRE,DCLRE1C,CD8B1, Cd79b,BTK,TAP2,ZAP70 |
| nodeficiency | UNG,CD40,CD79A,LCK,CD8A,AICDA,RAG1,CD19,ZAP70,ORAI1 |
Protein Function
IL7R has several biochemical functions, for example, antigen binding,interleukin-7 receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL7R itself. We selected most functions IL7R had, and list some proteins which have the same functions with IL7R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | VPS45,MKRN1,RAP1GDS1,SPRR1A,BNIP1,KLHL3,PIAS1,CDC42EP4,ANAPC4,LIMK2 |
| antigen binding | Ighg,LILRA3,IGJ,Ighg2a,IGKV1-5,IGLL1,IGHM,Ighg2b,TSPAN4,FCN3 |
Interacting Protein
IL7R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL7R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL7R.
IL7;IL2RG;hmwC
Resources
Research Area
Natural Killer Cells (NK Cells) MarkersNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
Natural Killer T (NKT) Cells
Regulatory T Cells (Tregs)
T Cell Cytokine Signaling
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
CD Antigen (Helper T Cells)
CD Antigen (Regulatory T Cells)
Hematopoietic Progenitor Cell Markers
Lymphoid Lineage Markers
Cytokines and Chemokines in B Cell Development
Common gamma Chain Family Receptors
Related Services
Related Products
References
- Bayer, DK; Martinez, CA; et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:459-469(2014).
- Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
