IL7R
-
Official Full Name
IL7R interleukin 7 receptor
-
Overview
CD127 is a 60-90 kD type I transmembrane glycoprotein, also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development. -
Synonyms
IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Callithrix jacchus (White-tufted-ear marmoset)
- Chicken
- Cynomolgus Monkey
- Equus caballus (Horse)
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293 cells
- HEK293F
- HEK293T
- Human Cell
- Human Cells
- Human embryonic kidney cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Avi
- Fc
- Flag
- GST
- Myc
- SUMO
- T7
- mFc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL7R involved in several pathways and played different roles in them. We selected most pathways IL7R participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL7R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | PDGFAA;CTF1;CXCL12;IRX1;THPO;IFNA2;IL7;CSF1R;Il6ra |
| FoxO signaling pathway | GABARAP;USP7;NLK1;AGAP2;S1PR1;INS2;S1PR4;PTENA;GADD45G |
| PIK-Akt signaling pathway | CREB3L3;PKN2;FGF2;TNC;TCL1B4;PPP2R3A;PPP2R2B;G6PC;GNB1 |
| Jak-STAT signaling pathway | IFNB1;PTPN11A;PRL;STAT1A;PTPN2;IL23R;IL27RA;IL9R;Il23a; Il12b |
| Hematopoietic cell lineage | TFRC;IL7R;IL9R;IL3RA;IL1R1;FLT3LG;IL5RA;MS4A1;GP5 |
| Primary i | AICDA;CD3D;CD40;RFXANK;RAG2;RFXAP;CD8B;PTPRC;LCK |
| nodeficiency | ZAP70;RFX5;RAG2;ICOS;CD3D;Cd79a, Cd79b;CD40LG;IL7R;PTPRC |
IL7R has several biochemical functions, for example, antigen binding, interleukin-7 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL7R itself. We selected most functions IL7R had, and list some proteins which have the same functions with IL7R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antigen binding | PPP2R1A;LILRB4;IGJ;FCN3;IL7R;Ighg2b;IgG3;KIR2DL3;TOPORS |
| interleukin-7 receptor activity | |
| protein binding | RIC8;RTN4RL2A;MYOCD;VPS35;ALKBH4;PIGS;NPPA;TULP3;ATG13 |
IL7R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL7R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL7R.
IL7; IL2RG; hmwC
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe pharmacodynamic parameters of IL7R were good.
IL7R has good compatibility and stability with various excipients.
Strong potential to desensitize specific allergens.
Q&As (6)
Ask a questionIL7R is a potential drug for tumor immunotherapy, which is expected to enhance anti-tumor immune response, but further research and clinical demonstration are still needed.
Recombinant IL7R can enhance the body's immune response, but there is not enough evidence to show that it can be used to treat immune system failure.
It can enhance the immune response ability of T cells and improve the immune response of the body, so as to have a therapeutic effect on immune-related diseases.
There is no clear evidence that IL7R has a synergistic effect with immune checkpoint inhibitors, but this research direction deserves further exploration.
IL7R has been associated with immune-related diseases such as cancer, inflammatory bowel disease, and rheumatoid arthritis.
The use of IL7R is patient specific and may be subject to some limitations, such as pregnant and lactating women and patients with certain immune-related diseases.
Ask a Question for All IL7R Products
Required fields are marked with *
My Review for All IL7R Products
Required fields are marked with *
