IL7R Protein


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Official Full Name IL7R interleukin 7 receptor
Background CD127 is a 60-90 kD type I transmembrane glycoprotein, also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
Synonyms IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Human Cell
    • Human Cells
    • Human embryonic kidney cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • Avi
    • Fc
    • Fc Chimera
    • Fc/Avi
    • His
    • GST
    • T7
    • His-SUMO
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL7R-129H Recombinant Human Interleukin 7 Receptor, Fc Chimera HEK293 Fc
    Human IL7R-130H Recombinant Human IL7R Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human IL7R-1951H Recombinant Human IL7R protein, His & GST-tagged E.coli His/GST
    Human IL7R-2260H Recombinant Human IL7R, His tagged Human Cell His
    Human IL7R-29272TH Recombinant Human IL7R N/A
    Human IL7R-301H Recombinant Human Interleukin 7 Receptor, MIgG2a Fc-tagged CHO Fc
    Human IL7R-302H Recombinant Human Interleukin 7 Receptor, HIgG1 Fc-tagged CHO Fc
    Human IL7R-788H Recombinant Human IL7R, Fc-His tagged Human Cell Fc/His
    Human IL7R-951H Recombinant Human IL7R Protein, Fc/His-tagged HEK293 Fc/His
    Mouse Il7r-1758M Recombinant Mouse Interleukin 7 Receptor Mammalian cells N/A
    Mouse Il7r-1952M Recombinant Mouse Il7r protein, His-tagged E.coli His
    Mouse Il7r-3272M Recombinant Mouse Il7r, His tagged Human Cell His
    Rat Il7r-1953R Recombinant Rat Il7r protein, His & T7-tagged E.coli His/T7
    Rat IL7R-291R Recombinant Rat Il7r, His tagged Human Cell His
    Rat Il7r-679R Recombinant Rat Il7r, Fc Chimera Mammalian cells Fc Chimera
    Rat Il7r-8711R Recombinant Rat Il7r, Fc tagged Human Cell Fc
    Cynomolgus Monkey IL7R-1231C Recombinant Cynomolgus IL7R Protein, His-tagged HEK293 His
    Cynomolgus Monkey IL7R-621C Recombinant Cynomolgus IL7R Protein, His-tagged Mammalian Cell His
    Chicken IL7R-3603C Recombinant Chicken IL7R Mammalian Cell His
    Zebrafish IL7R-6306Z Recombinant Zebrafish IL7R Mammalian Cell His
    Human IL7R-2595HCL Recombinant Human IL7R cell lysate Human Cell N/A
    Mouse IL7R-2473MCL Recombinant Mouse IL7R cell lysate Human Cell N/A
    Rat IL7R-959RCL Recombinant Rat IL7R cell lysate Human Cell N/A
    Human IL7R-01H Recombinant Human IL7R Protein, His-tagged Human embryonic kidney cell His
    Human IL7R-051H Recombinant Human IL7R protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
    Human IL7R-1057H Recombinant Human IL7R Protein, His-tagged HEK293F N-His
    Human IL7R-151H Recombinant Human IL7R Protein, His-tagged Human Cells His
    Mouse Il7r-2233M Recombinant Mouse Il7r protein, His-tagged Insect Cell His
    Mouse Il7r-3107M Recombinant Mouse Il7r protein, His-SUMO-tagged E.coli His-SUMO
    Mouse Il7r-5453M Recombinant Mouse Il7r protein, His-tagged Yeast His
    Human IL7R-2179H Recombinant Human IL7R Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL7R-5168H Recombinant Human IL7R Protein, GST-tagged Wheat Germ GST
    Human IL7R-5169H Recombinant Human IL7R Protein Wheat Germ N/A
    Mouse Il7r-1247M Recombinant Mouse Il7r Protein, MYC/DDK-tagged HEK293T MYC/DDK

    IL7R involved in several pathways and played different roles in them. We selected most pathways IL7R participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL7R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction ACVR1BA; BMPR1BA; CCL27; IFNA5; BMP7A; IL29; IL1A; CLCF1; IFNA3; IL20RB
    FoxO signaling pathway INSRA; SMAD3; MAPK12; PIK3R3A; CDKN1BA; Fasl; SMAD4; PTENA; INS2; NRAS
    PIK-Akt signaling pathway LPAR6; GNG2; NOS3; GSK3B; TCL1; INS; ITGB4; PIK3CD; IFNA13; GHR
    Jak-STAT signaling pathway IL4; CCND3; STAT5B; AKT2; IFNA5; SOCS7; IL15RA; HRASA; HRAS; IL22RA2
    Hematopoietic cell lineage CD37; ITGA2B; IL3; CD3D; CD1d1; FCGR1A; HLA-DRB5; CD8A; CD9; MME
    Primary i AICDA; CD8B; BLNK; CD8A; CD19; IGLL1; ORAI1; BTK; DCLRE1C; IL7R
    nodeficiency LCK; RFXAP; TAP2; IKBKG; RAG2; CD8B; CD8A; RFX5; RFXANK; DCLRE1C

    IL7R has several biochemical functions, for example, antigen binding, interleukin-7 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL7R itself. We selected most functions IL7R had, and list some proteins which have the same functions with IL7R. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding IGLC2; PPP2R1A; Ighg2b; IGKV1-5; LCK; SLAMF1; IgG3; TGFB1; LILRA2; LILRB4
    interleukin-7 receptor activity IL7R
    protein binding ALOX5AP; GNA13; HTR1E; TBX15; GABPA; EYA4; ZNHIT1; ATP6V1E1; KLHL20; ROBO2

    IL7R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL7R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL7R.

    IL7; IL2RG; hmwC

    Bayer, DK; Martinez, CA; et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:459-469(2014).
    Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).

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