IL7R

  • Official Full Name

    IL7R interleukin 7 receptor

  • Overview

    CD127 is a 60-90 kD type I transmembrane glycoprotein, also known as IL-7 receptor alpha chain or IL-7Ralpha. It forms heterodimer with the common gamma chain (gammac or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.
  • Synonyms

    IL7R; interleukin 7 receptor; interleukin-7 receptor subunit alpha; CD127; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; ILRA; IL7RA; CDW127; IL-7R-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Chicken
  • Cynomolgus Monkey
  • Equus caballus (Horse)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • Human embryonic kidney cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Avi|Fc
  • C
  • hFc
  • His
  • Avi
  • mFc
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Myc
  • His|GST
  • His|T7
  • SUMO
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL7R-2260H Recombinant Human IL7R protein, His-tagged HEK293 His
Human IL7R-130H Active Recombinant Human IL7R Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human IL7R-302H Active Recombinant Human Interleukin 7 Receptor, HIgG1 Fc-tagged CHO Fc
Human IL7R-051H Active Recombinant Human IL7R protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
Human IL7R-788H Recombinant Human IL7R, Fc-His tagged Human Cell Fc/His
Human IL7R-951H Recombinant Human IL7R Protein, Fc/His-tagged HEK293 Fc/His
Human IL7R-1951H Recombinant Human IL7R protein, His & GST-tagged E.coli His/GST
Human IL7R-129H Recombinant Human Interleukin 7 Receptor, Fc Chimera HEK293 Fc
Human IL7R-29272TH Recombinant Human IL7R N/A
Human IL7R-301H Active Recombinant Human Interleukin 7 Receptor, MIgG2a Fc-tagged CHO Fc
Human IL7R-2595HCL Recombinant Human IL7R cell lysate Human Cell N/A
Human IL7R-071H Recombinant Human IL7R Protein, C-His-tagged E.coli C-His
Human IL7R-2179H Recombinant Human IL7R Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL7R-1057H Recombinant Human IL7R Protein, His-tagged HEK293F N-His
Human IL7R-5168H Recombinant Human IL7R Protein, GST-tagged Wheat Germ GST
Human IL7R-1471HFL Recombinant Full Length Human IL7R Protein, C-Flag-tagged Mammalian cells Flag
Human IL7R-5169H Recombinant Human IL7R Protein Wheat Germ N/A
Human IL7R-1180H Recombinant Human IL7R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL7R-151H Recombinant Human IL7R Protein, His-tagged Human Cells His
Human IL7R-0303H Active Recombinant Human IL7R protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
Human IL7R-217H Recombinant Human IL7R Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human IL7R-336H Recombinant Human IL7R Protein, Fc-tagged HEK293 Fc
Human IL7R-01H Active Recombinant Human IL7R Protein, His-tagged Human embryonic kidney cell His
Human IL7R-0304H Active Recombinant Human IL7R protein, mFc-tagged HEK293 mFc
Human IL7R-1180H-B Recombinant Human IL7R Protein Pre-coupled Magnetic Beads HEK293
Human IL7R-0305H Active Recombinant Human IL7R protein(Met1-Gly236), hFc-tagged HEK293 C-hFc
Human IL7R-1207H Recombinant Human IL7R protein, His&Myc-tagged E.coli His&Myc
Human IL7R-1216H Recombinant Human IL7R Protein (Lys266-Gln459), N-His tagged E.coli N-His
Human IL7R-495M IL7R protein-coupled magnetic MicroBeads
Human IL7R-1361H Recombinant Human IL7R protein(Met1-Gly236), His&Avi-tagged, Biotinylated HEK293 C-His&Avi
Human IL7R-5698HF Recombinant Full Length Human IL7R Protein In Vitro Cell Free System
Human IL7R-4289H Recombinant Human IL7R Protein (Met1-Asp239), C-His tagged Mammalian cells C-His
Human IL7R-5701HF Recombinant Full Length Human IL7R Protein, GST-tagged In Vitro Cell Free System GST
Human IL7R-1886H Active Recombinant Human IL7R protein, Fc-tagged HEK293 Fc
Mouse Il7r-1952M Recombinant Mouse Il7r protein, His-tagged E.coli His
Mouse Il7r-3272M Recombinant Mouse Il7r, His tagged Human Cell His
Mouse Il7r-1758M Recombinant Mouse Interleukin 7 Receptor Mammalian cells N/A
Mouse IL7R-2473MCL Recombinant Mouse IL7R cell lysate Human Cell N/A
Mouse Il7r-10586M Recombinant Mouse Il7r Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il7r-5453M Recombinant Mouse Il7r protein, His-tagged Yeast His
Mouse Il7r-2233M Recombinant Mouse Il7r protein, His-tagged Insect Cell His
Mouse Il7r-1247M Recombinant Mouse Il7r Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il7r-3107M Recombinant Mouse Il7r protein, His-SUMO-tagged E.coli His-SUMO
Mouse Il7r-10586M-B Recombinant Mouse Il7r Protein Pre-coupled Magnetic Beads HEK293
Rat Il7r-679R Active Recombinant Rat Il7r, Fc Chimera Mammalian cells Fc Chimera
Rat Il7r-8711R Active Recombinant Rat Il7r protein(Met1-Asp239), mFc-tagged HEK293 C-mFc
Rat IL7R-291R Recombinant Rat Il7r, His tagged Human Cell His
Rat Il7r-1953R Recombinant Rat Il7r protein, His & T7-tagged E.coli His/T7
Rat IL7R-959RCL Recombinant Rat IL7R cell lysate Human Cell N/A
Rat Il7r-27R-B Recombinant Rat Il7r Protein Pre-coupled Magnetic Beads HEK293
Rat Il7r-27R Recombinant Rat Il7r Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Callithrix jacchus (White-tufted-ear marmoset) RFL2420CF Recombinant Full Length Callithrix Jacchus Interleukin-7 Receptor Subunit Alpha(Il7R) Protein, His-Tagged E.coli expression system His
Cynomolgus Monkey IL7R-621C Recombinant Cynomolgus IL7R Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IL7R-1231C Recombinant Cynomolgus IL7R Protein, His-tagged HEK293 His
Cynomolgus Monkey IL7R-367C Recombinant Cynomolgus Monkey IL7R Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IL7R-367C-B Recombinant Cynomolgus Monkey IL7R Protein Pre-coupled Magnetic Beads HEK293
Equus caballus (Horse) RFL8109EF Recombinant Full Length Horse Interleukin-7 Receptor Subunit Alpha(Il7R) Protein, His-Tagged E.coli expression system His
Homo sapiens (Human) RFL445HF Recombinant Full Length Human Interleukin-7 Receptor Subunit Alpha(Il7R) Protein, His-Tagged E.coli expression system His
Zebrafish IL7R-6306Z Recombinant Zebrafish IL7R Mammalian Cell His
Chicken IL7R-3603C Recombinant Chicken IL7R Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL7R Related Articles
  • IL7R Related Research Area

IL7R involved in several pathways and played different roles in them. We selected most pathways IL7R participated on our site, such as Cytokine-cytokine receptor interaction, FoxO signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL7R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL15RA;PRLR;TNFRSF11A;FLT3LG;KIT;IL9R;NT5C3;TNFRSF25;IL17A
FoxO signaling pathwayIGF1;FOXO1;PLK2;PIK3R3;MAP2K1;SGK2B;PIK3R5;IL7R;FBXO32
PIK-Akt signaling pathwayPPP2R5E;FGFR1;HGF;MTOR;FGF16;COL6A4;GNB4;NFKB1;THBS1
Jak-STAT signaling pathwayIl4ra;PTPN2B;PIK3R1;MCL1A;IL28A;IL-15RA;SOCS9;IFNB;STAT2
Hematopoietic cell lineageCSF1;KIT;GM-CSF;FCGR1A;ITGB3;GP1BA;Kitl;Itga10&Itgb1;GP9
Primary iICOS;CD79A;RAG2;CD19;IGLL1;CD3E;UNG;PTPRC;CD40LG
nodeficiencyIKBKG;TNFRSF13B;CD19;AICDA;UNG;CD8A;TAP2;IL7R;CD79A

IL7R has several biochemical functions, for example, antigen binding, interleukin-7 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL7R itself. We selected most functions IL7R had, and list some proteins which have the same functions with IL7R. You can find most of the proteins on our site.

Function Related Protein
antigen bindingCD40;LILRA1;IGJ;Ighg;IGLL1;Ighg2a;TSPAN4;HNRNPM;KIR2DL3
interleukin-7 receptor activity
protein bindingSUB1;E2F7;POLR2J;UBE2I;MAP3K4;ZBTB17;LEO1;DYNC1LI1;RHO

IL7R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL7R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL7R.

IL7; IL2RG; hmwC

Bayer, DK; Martinez, CA; et al. Vaccine-associated varicella and rubella infections in severe combined immunodeficiency with isolated CD4 lymphocytopenia and mutations in IL7R detected by tandem whole exome sequencing and chromosomal microarray. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:459-469(2014).
Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
  • Q&As
  • Reviews

Q&As (6)

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What is the prospect of recombinant IL7R in tumor immunotherapy? 11/19/2022

IL7R is a potential drug for tumor immunotherapy, which is expected to enhance anti-tumor immune response, but further research and clinical demonstration are still needed.

Is there any research showing that recombinant IL7R can be used to treat immune system failure? 09/23/2022

Recombinant IL7R can enhance the body's immune response, but there is not enough evidence to show that it can be used to treat immune system failure.

How the role of IL7R in immunotherapy? 05/05/2022

It can enhance the immune response ability of T cells and improve the immune response of the body, so as to have a therapeutic effect on immune-related diseases.

Does IL7R have synergistic effects with immune checkpoint inhibitors? 04/20/2022

There is no clear evidence that IL7R has a synergistic effect with immune checkpoint inhibitors, but this research direction deserves further exploration.

Which diseases is IL7R associated with? 08/03/2020

IL7R has been associated with immune-related diseases such as cancer, inflammatory bowel disease, and rheumatoid arthritis.

Is there any restriction on the use of IL7R? 10/13/2019

The use of IL7R is patient specific and may be subject to some limitations, such as pregnant and lactating women and patients with certain immune-related diseases.

Customer Reviews (3)

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Reviews
02/21/2022

    The pharmacodynamic parameters of IL7R were good.

    02/01/2022

      IL7R has good compatibility and stability with various excipients.

      09/30/2021

        Strong potential to desensitize specific allergens.

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