Recombinant Human INHBB Protein, GST-tagged

• Cat.No.: INHBB-5118H
• Product Overview: Human INHBB full-length ORF ( AAH30029.1, 1 a.a. - 407 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 71.6 kDa
• AA Sequence: MDGLPGRALGAACLLLLAAGWLGPE AWGSPTPPPTPAAQPPPPPPGSPGG SQDTCTSCGGFRRPEELGRVDGDFL EAVKRHILSRLQMRGRPNITHAVPK AAMVTALRKLHAGKVREDGRVEIPH LDGHASPGADGQERVSEIISFAETD GLASSRVRLYFFISNEGNQNLFVVQ ASLWLYLKLLPYVLEKGSRRKVRVK VYFQEQGHGDRWNMVEKRVDLKRSG WHTFPLTEAIQALFERGERRLNLDV QCDSCQELAVVPVFVDPGEESHRPF VVVQARLGDSRHRIRKRGLECDGRT NLCCRQQFFIDFRLIGWNDWIIAPT SYYGNYCEGSCPAYLAGVPGSASSF HTAVVNQYRMRGLNPGTVNSCCIPT KLSTMSMLYFDDEYNIVKRDVPNMI VEECGCA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: INHBB inhibin, beta B [ Homo sapiens ]
• Official Symbol: INHBB
• Synonyms: INHBB; inhibin, beta B; inhibin, beta B (activin AB beta polypeptide); inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide; MGC157939
• Gene ID: 3625
• mRNA Refseq: NM_002193
• Protein Refseq: NP_002184
• MIM: 147390
• UniProt ID: P09529