Recombinant Human Activin-B
| Cat.No. : | Activin-B-3122H |
| Product Overview : | Activin-B |
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| Species : | Human |
| Source : | Nicotiana Benthamiana |
| Tag : | Non |
| Protein Length : | 407 |
| Description : | The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. |
| Form : | Lyophilized |
| Molecular Mass : | 45,122 Da |
| Purity : | >97% by SDS-PAGE gel |
| Notes : | Small volumes of Activin-B recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
| Storage : | This lyophilized preparation is stable at 2-8 degree C for short term, long storage it should be kept at -20 degree C. Reconstituted protein should be stored in working aliquots at -20 degree C and it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended. |
| Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name | INHBB inhibin, beta B [ Homo sapiens ] |
| Official Symbol | INHBB |
| Synonyms | INHBB; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide |
| Gene ID | 3625 |
| mRNA Refseq | NM_002193 |
| Protein Refseq | NP_002184 |
| MIM | 147390 |
| UniProt ID | P09529 |
| Chromosome Location | 2cen-q13 |
| Pathway | AGE/RAGE pathway, organism-specific biosystem; Antagonism of Activin by Follistatin, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem |
| Function | cytokine activity; growth factor activity; hormone activity |
Not For Human Consumption!
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